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  • Open Access

    REVIEW

    Evaluation and research progress on rodent models of late-onset hypogonadism: a comprehensive review

    Zheng Liu1,#, Xuhong Yan2,#, Guicheng Liu1, Jingyi Zhang1, Xujun Yu3, Degui Chang1,*, Liang Dong3,*

    Canadian Journal of Urology, Vol.32, No.5, pp. 385-400, 2025, DOI:10.32604/cju.2025.068136 - 30 October 2025

    Abstract Late-onset hypogonadism (LOH), characterized by the intersection of aging and androgen deficiency, impacts the health of approximately 2%−39% of middle-aged and elderly men, underscoring the need for comprehensive research. Animal models, serving as analogs of human diseases, are indispensable for investigating disease mechanisms and facilitating drug development. However, the diverse array of animal models utilized for LOH research has led to a lack of standardized modeling approaches and evaluation systems, potentially impeding progress in understanding the pathogenesis and therapeutic development. In this paper, we summarize and compile the characteristics, methods, and evaluation systems of rodent More >

  • Open Access

    ARTICLE

    Shock-Boundary Layer Interaction in Transonic Flows: Evaluation of Grid Resolution and Turbulence Modeling Effects on Numerical Predictions

    Mehmet Numan Kaya*

    CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 327-343, 2025, DOI:10.32604/cmes.2025.072000 - 30 October 2025

    Abstract This study investigates the influence of mesh resolution and turbulence model selection on the accuracy of numerical simulations for transonic flow, with particular emphasis on shock-boundary layer interaction phenomena. Accurate prediction of such flows is notoriously difficult due to the sensitivity to near-wall resolution, global mesh density, and turbulence model assumptions, and this problem motivates the present work. Two solvers were employed, rhoCentralFoam (unsteady) and TSLAeroFoam (steady-state), both are compressible and density-based and implemented within the OpenFOAM framework. The investigation focuses on three different non-dimensional wall distance (y+) values of 1, 2.5 and 5, each implemented… More >

  • Open Access

    ARTICLE

    Exploring Adolescents’ Social Anxiety, Physical Activity, and Core Self-Evaluation: A Latent Profile and Mediation Approach

    Huazhe Wan1, Wenying Huang2, Wen Zhang2, Chang Hu2,*

    International Journal of Mental Health Promotion, Vol.27, No.10, pp. 1611-1626, 2025, DOI:10.32604/ijmhp.2025.070457 - 31 October 2025

    Abstract Background: Social anxiety is prevalent among adolescents and severely impacts their mental health and social functioning. This study aims to explore the underlying mechanisms and subgroup differences in adolescent social anxiety to provide a theoretical basis for targeted interventions. Methods: 3025 Chinese adolescents (Meanage = 13.91 ± 1.60 years; 47% male) completed self-report measures of physical activity, core self-evaluation, and social anxiety. Variable-centered analyses employed PROCESS Model 4 with 5000 bootstrap samples; covariates were gender, grade, and place of residence. Person-centered analyses used latent profile analysis in Mplus 8.3 to identify subgroups based on social anxiety… More >

  • Open Access

    ARTICLE

    Understanding Academic Evaluation Anxiety in Portuguese Adolescents: A Psychosocial and Educational Perspective

    Marta Reis1,2,3,4,5,*, Catarina Noronha6, Gina Tomé3,4,5, Marina Carvalho4,6, Nuno Neto Rodrigues7, Margarida Gaspar de Matos3,4,6

    International Journal of Mental Health Promotion, Vol.27, No.10, pp. 1457-1470, 2025, DOI:10.32604/ijmhp.2025.070318 - 31 October 2025

    Abstract Objectives: Academic Evaluation Anxiety is a significant psychological concern among adolescents, with well-documented impacts on academic performance, emotional well-being, and school engagement. In Portugal, recent evidence suggests growing pressure on students to achieve high academic standards, with psychosocial variables such as resilience, perceived support, and school environment playing a crucial role. This study aims to examine the prevalence and psychosocial predictors of Academic Evaluation Anxiety in Portuguese students, and to identify risk and protective factors that inform educational practice. Methods: This cross-sectional, quantitative study analysed data from 3083 students (5th to 12th grade) from the… More >

  • Open Access

    ARTICLE

    Reducing Stigma and Promoting Empowerment: A Pre-Post Evaluation of ACE-LYNX Intervention on the Mental Health Literacy of University Providers

    Fenghua Wang1, Jianguo Gao1,*, Zhi-Ying Yao2, Kenneth Po-Lun Fung3, Cun-Xian Jia2, Sheng-Li Cheng1, Josephine Pui-Hing Wong4

    International Journal of Mental Health Promotion, Vol.27, No.10, pp. 1497-1514, 2025, DOI:10.32604/ijmhp.2025.069458 - 31 October 2025

    Abstract Background: Limited mental health literacy (MHL) among university service providers is a significant obstacle to effective psychological support. Developing and systematically assessing evidence-based interventions is an urgent priority, particularly in low- and middle-income countries (LMICs). This study aimed to evaluate the effectiveness of the Acceptance & Commitment to Empowerment: Linking Youths AND ‘Xin’ (Hearts) (ACE-LYNX) intervention in reducing stigma, improving psychological well-being, and enhancing the MHL and empowerment practices of university mental health providers in China. Methods: A total of 124 trained providers participated in this longitudinal study. Quantitative data were collected at baseline, immediately… More >

  • Open Access

    ARTICLE

    Multi-Environment Evaluation of Soybean Genotypes for Yield, Stability, and Trait Associations in Croatia

    Ivica Delic1, Goran Jukic2, Ivan Varnica2, Valentina Spanic3,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3189-3203, 2025, DOI:10.32604/phyton.2025.070489 - 29 October 2025

    Abstract This study evaluated agro-morphological traits, grain quality traits, and phenotypic stability of nine soybean genotypes across four environments over two growing seasons (2022–2023). Traits such as days to flowering, days to maturity, and disease symptoms were monitored throughout the season. At maturity, parameters including grain yield, grain oil and protein content, 1000-seed weight, test weight, scores of lodgings, shattering, plant height, and first pod height were evaluated. In addition, 18 morphological traits were scored, of which eight were sufficiently variable for further analysis. In terms of environmental stability, genotypes 2 and 13 excelled, while genotypes… More >

  • Open Access

    ARTICLE

    A Novel Low-Damage Viscoelastic-Surfactant Foam Fracturing Fluid for Tight Reservoirs: Development and Performance Assessment

    Yu Li1,2,3,*, Jie Bian3, Liang Zhang2,3, Xuesong Feng3, Jiachen Hu3, Ji Yu3, Chao Zhou3, Tian Lan3

    FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.10, pp. 2539-2556, 2025, DOI:10.32604/fdmp.2025.067685 - 30 October 2025

    Abstract As oil and gas development increasingly targets unconventional reservoirs, the limitations of conventional hydraulic fracturing, namely high water consumption and significant reservoir damage, have become more pronounced. This has driven growing interest in the development of clean fracturing fluids that minimize both water usage and formation impairment. In this study, a low-liquid-content viscoelastic surfactant (VES) foam fracturing fluid system was formulated and evaluated through laboratory experiments. The optimized formulation comprises 0.2% foaming agent CTAB (cetyltrimethylammonium bromide) and 2% foam stabilizer EAPB (erucamidopropyl betaine). Laboratory tests demonstrated that the VES foam system achieved a composite foam… More >

  • Open Access

    ARTICLE

    Planning and Evaluation Method of MMC-MTEDC Network Construction of Urban Power Grid

    Jing Li1, Yinghua Xie1, Guoxing Wu1, Ming Xiao1, Guoteng Wang2, Keheng Lou2, Ying Huang2,*

    Energy Engineering, Vol.122, No.11, pp. 4475-4495, 2025, DOI:10.32604/ee.2025.068711 - 27 October 2025

    Abstract With the accelerating urbanization process, the load demand of urban power grids is constantly increasing, giving rise to a batch of ultra-large urban power grids featuring large electricity demand, dense load distribution, and tight construction land constraints. This paper establishes a network planning method for urban power grids based on series reactors and MMC-MTEDC, focusing on four aspects: short-circuit current suppression, accommodation of external power supply, flexible inter-regional power support, and voltage stability enhancement in load centers. It proposes key indicators including node short-circuit current margin, line thermal stability margin, maximum fault-induced regional power loss,… More >

  • Open Access

    ARTICLE

    DPZTN: Data-Plane-Based Access Control Zero-Trust Network

    Jingfu Yan, Huachun Zhou*, Weilin Wang

    Computer Systems Science and Engineering, Vol.49, pp. 499-531, 2025, DOI:10.32604/csse.2025.068151 - 10 October 2025

    Abstract The 6G network architecture introduces the paradigm of Trust + Security, representing a shift in network protection strategies from external defense mechanisms to endogenous security enforcement. While ZTNs (zero-trust networks) have demonstrated significant advancements in constructing trust-centric frameworks, most existing ZTN implementations lack comprehensive integration of security deployment and traffic monitoring capabilities. Furthermore, current ZTN designs generally do not facilitate dynamic assessment of user reputation. To address these limitations, this study proposes a DPZTN (Data-plane-based Zero Trust Network). DPZTN framework extends traditional ZTN models by incorporating security mechanisms directly into the data plane. Additionally, blockchain infrastructure… More > Graphic Abstract

    DPZTN: Data-Plane-Based Access Control Zero-Trust Network

  • Open Access

    ARTICLE

    Application of a Hyperbranched Amide Polymer in High-Temperature Drilling Fluids: Inhibiting Barite Sag and Action Mechanisms

    Qiang Sun1,2,*, Zheng-Song Qiu1, Tie Geng2, Han-Yi Zhong1, Weili Liu2, Yu-Lin Tang2, Jin-Cheng Dong2

    Journal of Polymer Materials, Vol.42, No.3, pp. 757-772, 2025, DOI:10.32604/jpm.2025.069808 - 30 September 2025

    Abstract Addressing the critical challenges of viscosity loss and barite sag in synthetic-based drilling fluids (SBDFs) under high-temperature, high-pressure (HTHP) conditions, this study innovatively developed a hyperbranched amide polymer (SS-1) through a unique stepwise polycondensation strategy. By integrating dynamic ionic crosslinking for temperature-responsive rheology and rigid aromatic moieties ensuring thermal stability beyond 260°C, SS-1 achieves a molecular-level breakthrough. Performance evaluations demonstrate that adding merely 2.0 wt% SS-1 significantly enhances key properties of 210°C-aged SBDFs: plastic viscosity rises to 45 mPa·s, electrical stability (emulsion voltage) reaches 1426 V, and the sag factor declines to 0.509, outperforming conventional More >

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