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  • Open Access


    Micro-RNA-21 Regulates Cancer-Associated Fibroblast-Mediated Drug Resistance in Pancreatic Cancer

    Lulin Zhang, Jun Yao, Wenyao Li, Ce Zhang

    Oncology Research, Vol.26, No.6, pp. 827-836, 2018, DOI:10.3727/096504017X14934840662335

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths due to its highly aggressive biological nature and resistance to chemotherapy. Previous studies indicate that miR-21 is an important regulator in the activation of cancer-associated fibroblasts (CAFs). However, whether miR-21 in CAFs would regulate PDAC’s tumor microenvironment and lead to drug resistance remain unknown. In this study, we evaluated the relationship between CAF activation, miR-21 expression, and drug resistance using tumor samples from PDAC patients. We changed the miR-21 expression level in CAFs and tested its roles in regulating the function of… More >

  • Open Access


    The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory


    Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112

    Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract

    The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

  • Open Access


    HIFs in hypoxic regulation of the extracellular matrix: focus on little-known player HIF-3


    BIOCELL, Vol.48, No.5, pp. 677-692, 2024, DOI:10.32604/biocell.2024.048873

    Abstract The structural and associated molecules of the extracellular matrix (ECM) complex is an important component of the local milieu of cells, both for maintaining their functions and homeostasis. It is a dynamic structure that is finely tuned to changes in the microenvironment. One of these factors is hypoxia, which can arise in tissues due to physiological or pathological effects. As a result of the hypoxic effect, the properties of the ECM are significantly modified, stiffness increases, the balance between degradation and synthesis of structural proteins shifts, and the deposition of biologically active mediators’ changes. Hypoxia-inducible… More >

  • Open Access


    Research on the Method of Heat Preservation and Heating for the Drilling System of Polar Offshore Drilling Platform

    Yingkai Dong1,2, Chaohe Chen2,*, Guangyan Jia2, Lidai Wang3, Jian Bai1

    Energy Engineering, Vol.121, No.5, pp. 1173-1193, 2024, DOI:10.32604/ee.2024.046432

    Abstract This study investigates the heat dissipation mechanism of the insulation layer and other plane insulation layers in the polar drilling rig system. Combining the basic theory of heat transfer with the environmental requirements of polar drilling operations and the characteristics of polar drilling processes, we analyze the factors that affect the insulation effect of the drilling rig system. These factors include the thermal conductivity of the insulation material, the thickness of the insulation layer, ambient temperature, and wind speed. We optimize the thermal insulation material of the polar drilling rig system using a steady-state method… More >

  • Open Access


    Robust and Trustworthy Data Sharing Framework Leveraging On-Chain and Off-Chain Collaboration

    Jinyang Yu1,2, Xiao Zhang1,2,3,*, Jinjiang Wang1,2, Yuchen Zhang1,2, Yulong Shi1,2, Linxuan Su1,2, Leijie Zeng1,2,*

    CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 2159-2179, 2024, DOI:10.32604/cmc.2024.047340

    Abstract The proliferation of Internet of Things (IoT) systems has resulted in the generation of substantial data, presenting new challenges in reliable storage and trustworthy sharing. Conventional distributed storage systems are hindered by centralized management and lack traceability, while blockchain systems are limited by low capacity and high latency. To address these challenges, the present study investigates the reliable storage and trustworthy sharing of IoT data, and presents a novel system architecture that integrates on-chain and off-chain data manage systems. This architecture, integrating blockchain and distributed storage technologies, provides high-capacity, high-performance, traceable, and verifiable data storage… More >

  • Open Access


    Einstein Hybrid Structure of q-Rung Orthopair Fuzzy Soft Set and Its Application for Diagnosis of Waterborne Infectious Disease

    Rana Muhammad Zulqarnain1, Hafiz Khalil ur Rehman2, Imran Siddique3, Hijaz Ahmad4,5, Sameh Askar6, Shahid Hussain Gurmani1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1863-1892, 2024, DOI:10.32604/cmes.2023.031480

    Abstract This research is devoted to diagnosing water-borne infectious diseases caused by floods employing a novel diagnosis approach, the Einstein hybrid structure of q-rung orthopair fuzzy soft set. This approach integrates parts of fuzzy logic and soft set theory to develop a robust alternative for disease detection in stressful situations, especially in areas affected by floods. Compared to the traditional intuitionistic fuzzy soft set and Pythagorean fuzzy soft set, the q-rung orthopair fuzzy soft set (q-ROFSS) adequately incorporates unclear and indeterminate facts. The major objective of this investigation is to formulate the q-rung orthopair fuzzy soft… More >

  • Open Access


    An Intelligent MCGDM Model in Green Suppliers Selection Using Interactional Aggregation Operators for Interval-Valued Pythagorean Fuzzy Soft Sets

    Rana Muhammad Zulqarnain1, Wen-Xiu Ma1,2,3,*, Imran Siddique4, Hijaz Ahmad5,6, Sameh Askar7

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1829-1862, 2024, DOI:10.32604/cmes.2023.030687

    Abstract Green supplier selection is an important debate in green supply chain management (GSCM), attracting global attention from scholars, especially companies and policymakers. Companies frequently search for new ideas and strategies to assist them in realizing sustainable development. Because of the speculative character of human opinions, supplier selection frequently includes unreliable data, and the interval-valued Pythagorean fuzzy soft set (IVPFSS) provides an exceptional capacity to cope with excessive fuzziness, inconsistency, and inexactness through the decision-making procedure. The main goal of this study is to come up with new operational laws for interval-valued Pythagorean fuzzy soft numbers More >

  • Open Access


    Fault Diagnosis Method of Rolling Bearing Based on ESGMD-CC and AFSA-ELM

    Jiajie He1,2, Fuzheng Liu3, Xiangyi Geng3, Xifeng Liang1, Faye Zhang3,*, Mingshun Jiang3

    Structural Durability & Health Monitoring, Vol.18, No.1, pp. 37-54, 2024, DOI:10.32604/sdhm.2023.029428

    Abstract Incomplete fault signal characteristics and ease of noise contamination are issues with the current rolling bearing early fault diagnostic methods, making it challenging to ensure the fault diagnosis accuracy and reliability. A novel approach integrating enhanced Symplectic geometry mode decomposition with cosine difference limitation and calculus operator (ESGMD-CC) and artificial fish swarm algorithm (AFSA) optimized extreme learning machine (ELM) is proposed in this paper to enhance the extraction capability of fault features and thus improve the accuracy of fault diagnosis. Firstly, SGMD decomposes the raw vibration signal into multiple Symplectic geometry components (SGCs). Secondly, the More >

  • Open Access


    Ice-Induced Vibrational Response of Single-Pile Offshore Wind-Turbine Foundations

    Zhoujie Zhu1, Gang Wang1, Qingquan Liu1, Guojun Wang2, Rui Dong2, Dayong Zhang2,3,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.3, pp. 625-639, 2024, DOI:10.32604/fdmp.2023.042128

    Abstract Important challenges must be addressed to make wind turbines sustainable renewable energy sources. A typical problem concerns the design of the foundation. If the pile diameter is larger than that of the jacket platform, traditional mechanical models cannot be used. In this study, relying on the seabed soil data of an offshore wind farm, the m-method and the equivalent embedded method are used to address the single-pile wind turbine foundation problem for different pile diameters. An approach to determine the equivalent pile length is also proposed accordingly. The results provide evidence for the effectiveness and reliability More >

  • Open Access


    Field Observation and Numerical Simulation of Extreme Met-Ocean Conditions: A Case Study of Typhoon Events in South China Sea

    Chen Gu1,*, Caiyu Wang1, Mengjiao Du2, Kan Yi2, Bihong Zhu1, Hao Wang2, Shu Dai1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09776

    Abstract Site measurement is essential to the meteorological and oceanographic parameters of offshore wind farms. A floating lidar measurement buoy was deployed at a Qingzhou VI wind farm where is 45-80 km away from Guangdong coast. The field observation including wind and wave data start from March, 2021.The lidar wind data is compared and calibrated with the fixed wind tower data for three months, the accuracy meets the standard of stadge3 carbon trust. In this study, all these data are used to recalibrate for the met-ocean model to relies extreme conditions, such as Typhoon Kompasu(2118) and More >

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