Shuwen Sun1,2,3,4,#, Jingcheng Zhang1,2,3,#, Zongtai Zheng5,#, Yajuan Hao1,3, Tianyuan Xu1,2,3, Ji Liu1,3, Liang Sun2, Aimin Wang2, Yadong Guo1,3, Shiyu Mao1,3, Xu Zhang6, Yunfei Xu1,3,*, Yifan Chen1,2,3,*, Yang Yan1,2,3,*
Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.072373
- 23 March 2026
Abstract Objectives: Bladder cancer (BCa) progression is closely linked to the immune microenvironment. However, the key molecules that regulate this microenvironment and their specific mechanisms remain poorly understood. This study aims to identify a key molecule and elucidate its mechanisms, providing a theoretical basis for identifying novel therapeutic targets. Methods: Immune microenvironment-related genes in BCa were identified using The Cancer Genome Atlas and Shanghai Tenth People’s Hospital datasets. Proteasome 26S subunit non-ATPase 2 (PSMD2) expression was validated via quantitative polymerase chain reaction (qPCR), Western blot (WB) analysis, and immunofluorescence (IF). In vitro and in vivo experiments confirmed the… More >
Graphic Abstract