JIAZHUANG LI*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU
BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860
Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical
practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric
cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric
cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were
predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays
were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell
functions and trastuzumab resistance of… More >
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