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  • Open Access

    ARTICLE

    Coverless Image Steganography System Based on Maze Game Generation

    Al Hussien Seddik Saad1, Mohammed S. Reda2, Gamal M. Behery2, Ahmed A. El-harby2, Mohammed Baz3, Mohamed Abouhawwash4,5,*, Ahmed Ismail Ebada6

    Intelligent Automation & Soft Computing, Vol.38, No.2, pp. 125-138, 2023, DOI:10.32604/iasc.2023.032084

    Abstract The trend of digital information transformation has become a topic of interest. Many data are threatening; thus, protecting such data from attackers is considered an essential process. Recently, a new methodology for data concealing has been suggested by researchers called coverless steganography. Coverless steganography can be accomplished either by building an image database to match its image subblocks with the secret message to obtain the stego image or by generating an image. This paper proposes a coverless image steganography system based on pure image generation using secret message bits with a capacity higher than the other traditional systems. The system… More >

  • Open Access

    ARTICLE

    Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

    WEIXUE WANG#, TONGTONG WANG#, YAN ZHANG, TING DENG, HAIYANG ZHANG*, YI BA*

    Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

    Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

  • Open Access

    REVIEW

    A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma

    ELHAM AMJAD1, RAFFAELE PEZZANI2,3,*, BABAK SOKOUTI1,*

    Oncology Research, Vol.32, No.3, pp. 439-461, 2024, DOI:10.32604/or.2023.044473

    Abstract Noncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient’s outcome is poor. As a result of the emergence of therapeutic resistance in HCC patients, clinicians have faced difficulties in treating such tumor. In addition, CRISPR/Cas9 screens were used to identify genes that improve the clinical response of HCC patients. It is the objective of this article to summarize the current understanding of the use of the CRISPR/Cas9 system for the treatment of cancer, with a particular emphasis on HCC as part of the current state… More >

  • Open Access

    ARTICLE

    Low expression of fatty acid oxidation related gene ACADM indicates poor prognosis of renal clear cell carcinoma and is related to tumor immune infiltration

    JIECHUAN QIU1, TIANMIN YANG1, YANNING SUN2, KAI SUN2, YINGKUN XU3, QINGHUA XIA1,*

    Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462

    Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was assessed using a diagnostic receiver… More >

  • Open Access

    ARTICLE

    Role of oncogenic long noncoding RNA KCNQ1OT1 in colon cancer

    GANG LIU1,#, LEI SHI1,#, BIN WANG1, ZEHUI WU1, HAIYUAN ZHAO1, TIANYU ZHAO2, LIANGHUI SHI1,*

    Oncology Research, Vol.32, No.3, pp. 585-596, 2024, DOI:10.32604/or.2023.029349

    Abstract The role of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in colon cancer involves various tumorigenic processes and has been studied widely. However, the mechanism by which it promotes colon cancer remains unclear. Retroviral vector pSEB61 was retrofitted in established HCT116-siKCN and SW480-siKCN cells to silence KCNQ1OT1. Cellular proliferation was measured using CCK8 assay, and flow cytometry (FCM) detected cell cycle changes. RNA sequencing (RNA-Seq) analysis showed differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to analyze enriched functions and signaling pathways. RT-qPCR, immunofluorescence, and western blotting… More >

  • Open Access

    ARTICLE

    Internet Use and Mental Health among Older Adults in China: Beneficial for Those Who Lack of Intergenerational Emotional Support or Suffering from Chronic Diseases?

    Yuxin Wang1,2,*, Jia Shi1,2

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 69-80, 2024, DOI:10.32604/ijmhp.2023.044641

    Abstract In the 21st century, the rapid growth of the Internet has presented a significant avenue for China to respond actively to the aging population and promote the “Healthy China” strategy in an orderly manner. This study uses panel data from the China Health and Retirement Longitudinal Study (CHARLS) to empirically investigate the influence of Internet use on the mental health of older adults, particularly those who lack intergenerational emotional support and suffer from chronic diseases. This study employs a multi-period difference-in-differences (DID) method and a two-stage instrumental variable approach to address the endogenous problem. Results show that Internet use has… More >

  • Open Access

    ARTICLE

    Smad8 is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice

    DAOLUN YU1, DEYONG SHE2, KAI GE1, LEI YANG1, RUINA ZHAN1, SHAN LU3,*, YAFEI CAI4,*

    BIOCELL, Vol.48, No.1, pp. 139-147, 2024, DOI:10.32604/biocell.2023.045884

    Abstract Background: SMAD family proteins (SMADs) are crucial transcription factors downstream of transforming growth factor beta (TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction. However, the role of SMAD family member 8 (SMAD8, also known as SMAD9), a member of the SMAD family, in mammalian reproduction remains unclear. Methods: We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells (GCs) to investigate the effects of Smad8 on GC growth and steroidogenesis. Results: Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate… More >

  • Open Access

    REVIEW

    In vitro engineered models of neurodegenerative diseases

    ZEHRA GÜL MORÇIMEN1, ŞEYMA TAŞDEMIR2, AYLIN ŞENDEMIR3,4,*

    BIOCELL, Vol.48, No.1, pp. 79-96, 2024, DOI:10.32604/biocell.2023.045361

    Abstract Neurodegeneration is a catastrophic process that develops progressive damage leading to functional and structural loss of the cells of the nervous system and is among the biggest unavoidable problems of our age. Animal models do not reflect the pathophysiology observed in humans due to distinct differences between the neural pathways, gene expression patterns, neuronal plasticity, and other disease-related mechanisms in animals and humans. Classical in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting the complex pathophysiology of neurodegenerative diseases. Today, modern, engineered techniques are applied to develop multicellular, intricate in vitro models and to… More >

  • Open Access

    ARTICLE

    A Video Captioning Method by Semantic Topic-Guided Generation

    Ou Ye, Xinli Wei, Zhenhua Yu*, Yan Fu, Ying Yang

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 1071-1093, 2024, DOI:10.32604/cmc.2023.046418

    Abstract In the video captioning methods based on an encoder-decoder, limited visual features are extracted by an encoder, and a natural sentence of the video content is generated using a decoder. However, this kind of method is dependent on a single video input source and few visual labels, and there is a problem with semantic alignment between video contents and generated natural sentences, which are not suitable for accurately comprehending and describing the video contents. To address this issue, this paper proposes a video captioning method by semantic topic-guided generation. First, a 3D convolutional neural network is utilized to extract the… More >

  • Open Access

    ARTICLE

    Research on Flexible Job Shop Scheduling Based on Improved Two-Layer Optimization Algorithm

    Qinhui Liu, Laizheng Zhu, Zhijie Gao, Jilong Wang, Jiang Li*

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 811-843, 2024, DOI:10.32604/cmc.2023.046040

    Abstract To improve the productivity, the resource utilization and reduce the production cost of flexible job shops, this paper designs an improved two-layer optimization algorithm for the dual-resource scheduling optimization problem of flexible job shop considering workpiece batching. Firstly, a mathematical model is established to minimize the maximum completion time. Secondly, an improved two-layer optimization algorithm is designed: the outer layer algorithm uses an improved PSO (Particle Swarm Optimization) to solve the workpiece batching problem, and the inner layer algorithm uses an improved GA (Genetic Algorithm) to solve the dual-resource scheduling problem. Then, a rescheduling method is designed to solve the… More >

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