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  • Open Access

    REVIEW

    Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

    YARA ALZGHOUL, HALA J. BANI ISSA, AHMAD K. SANAJLEH, TAQWA ALABDUH, FATIMAH RABABAH, MAHA AL-SHDAIFAT, EJLAL ABU-EL-RUB*, FATIMAH ALMAHASNEH, RAMADA R. KHASAWNEH, AYMAN ALZU’BI, HUTHAIFA MAGABLEH

    BIOCELL, Vol.48, No.4, pp. 559-569, 2024, DOI:10.32604/biocell.2024.048056

    Abstract Mesenchymal stem cells (MSCs) are ideal candidates for treating many cardiovascular diseases. MSCs can modify the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities, which are essential to restore heart function. MSCs can be easily isolated from different sources, including bone marrow, adipose tissues, umbilical cord, and dental pulp. MSCs from various sources differ in their regenerative and therapeutic abilities for cardiovascular disorders. In this review, we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function. More >

  • Open Access

    ARTICLE

    miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

    LIJUAN ZHANG1,#, QINGYIN MENG2,#, LI ZHUANG1, QUAN GONG1, XIANDA HUANG3, XUEQIN LI1, SHIJUAN LI1, GUOQIN WANG4, XICAI WANG5,*

    BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260

    Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells. Furthermore, we examined tumorigenesis and… More > Graphic Abstract

    miR-30a-5p/PHTF2 axis regulates the tumorigenesis and metastasis of lung adenocarcinoma

  • Open Access

    ARTICLE

    Bronchoalveolar lavage fluid metagenomic next-generation sequencing assay for identifying pathogens in lung cancer patients

    JIYU WANG1,2, HUIXIA LI1,2, DEYUAN ZHOU1,2, LIHONG BAI1,2, KEJING TANG1,2,3,*

    BIOCELL, Vol.48, No.4, pp. 623-637, 2024, DOI:10.32604/biocell.2024.030420

    Abstract Background: For patients with lung cancer, timely identification of new lung lesions as infectious or non-infectious, and accurate identification of pathogens is very important in improving OS of patients. As a new auxiliary examination, metagenomic next-generation sequencing (mNGS) is believed to be more accurate in diagnosing infectious diseases in patients without underlying diseases, compared with conventional microbial tests (CMTs). We designed this study to find out whether mNGS has better performance in distinguishing infectious and non-infectious diseases in lung cancer patients using bronchoalveolar lavage fluid (BALF). Materials and Methods: This study was a real-world retrospective review based on electronic medical… More >

  • Open Access

    ARTICLE

    Securing Mobile Cloud-Based Electronic Health Records: A Blockchain-Powered Cryptographic Solution with Enhanced Privacy and Efficiency

    Umer Nauman1, Yuhong Zhang2, Zhihui Li3, Tong Zhen1,3,*

    Journal of Intelligent Medicine and Healthcare, Vol.2, pp. 15-34, 2024, DOI:10.32604/jimh.2024.048784

    Abstract The convergence of handheld devices and cloud-based computing has transformed how Electronic Health Records (EHRs) are stored in mobile cloud paradigms, offering benefits such as affordability, adaptability, and portability. However, it also introduces challenges regarding network security and data confidentiality, as it aims to exchange EHRs among mobile users while maintaining high levels of security. This study proposes an innovative blockchain-based solution to these issues and presents secure cloud storage for healthcare data. To provide enhanced cryptography, the proposed method combines an enhanced Blowfish encryption method with a new key generation technique called Elephant Herding Optimization with Resistance-Based Training (EHO-RBT).… More >

  • Open Access

    ARTICLE

    Bio-Based Rigid Polyurethane Foams for Cryogenic Insulation

    Laima Vevere*, Beatrise Sture, Vladimir Yakushin, Mikelis Kirpluks, Ugis Cabulis

    Journal of Renewable Materials, Vol.12, No.3, pp. 585-602, 2024, DOI:10.32604/jrm.2024.047350

    Abstract Cryogenic insulation material rigid polyurethane (PU) foams were developed using bio-based and recycled feedstock. Polyols obtained from tall oil fatty acids produced as a side stream of wood biomass pulping and recycled polyethylene terephthalate were used to develop rigid PU foam formulations. The 4th generation physical blowing agents with low global warming potential and low ozone depletion potential were used to develop rigid PU foam cryogenic insulation with excellent mechanical and thermal properties. Obtained rigid PU foams had a thermal conductivity coefficient as low as 0.0171 W/m·K and an apparent density of 37–40 kg/m3. The developed rigid PU foams had… More > Graphic Abstract

    Bio-Based Rigid Polyurethane Foams for Cryogenic Insulation

  • Open Access

    ARTICLE

    The Influence of Internet Use on Women’s Depression and Its Countermeasures—Empirical Analysis Based on Data from CFPS

    Dengke Xu1, Linlin Shen1, Fangzhong Xu2,*

    International Journal of Mental Health Promotion, Vol.26, No.3, pp. 229-238, 2024, DOI:10.32604/ijmhp.2024.046023

    Abstract Based on China Family Panel Studies (CFPS) 2018 data, the multiple linear regression model is used to analyze the effects of Internet use on women’s depression, and to test the robustness of the regression results. At the same time, the effects of Internet use on mental health of women with different residence, age, marital status and physical health status are analyzed. Then, we can obtain that Internet use has a significant promoting effect on women’s mental health, while the degree of Internet use has a significant inhibitory effect on women’s mental health. In addition, the study found that women’s age,… More >

  • Open Access

    ARTICLE

    Genome-Wide Exploration of the Grape GLR Gene Family and Differential Responses of VvGLR3.1 and VvGLR3.2 to Low Temperature and Salt Stress

    Honghui Sun1,2,#, Ruichao Liu1,2,#, Yueting Qi1, Hongsheng Gao1, Xueting Wang1, Ning Jiang1,2, Xiaotong Guo1,2, Hongxia Zhang1, Chunyan Yu1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 533-549, 2024, DOI:10.32604/phyton.2024.049417

    Abstract Grapes, one of the oldest tree species globally, are rich in vitamins. However, environmental conditions such as low temperature and soil salinization significantly affect grape yield and quality. The glutamate receptor (GLR) family, comprising highly conserved ligand-gated ion channels, regulates plant growth and development in response to stress. In this study, 11 members of the VvGLR gene family in grapes were identified using whole-genome sequence analysis. Bioinformatic methods were employed to analyze the basic physical and chemical properties, phylogenetic trees, conserved domains, motifs, expression patterns, and evolutionary relationships. Phylogenetic and collinear analyses revealed that the VvGLRs were divided into three… More >

  • Open Access

    ARTICLE

    The Identification of Phenylalanine Ammonia-Lyase (PAL) Genes from Pinus yunnanensis and an Analysis of Enzyme Activity in vitro

    Dejin Mu1,2, Lin Chen1,2, Heze Wang1,2, Zhaoliu Hu1,2, Sihui Chen1,2, Shi Chen1,2, Nianhui Cai1,2, Yulan Xu1,2, Junrong Tang1,2,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 503-516, 2024, DOI:10.32604/phyton.2024.048786

    Abstract Phenylalanine ammonia lyase (PAL) is the rate-limiting and pivotal enzyme of the general phenylpropanoid pathway, but few reports have been found on PAL genes in Pinus yunnanensis. In the present study, three PAL genes were cloned and identified from P. yunnanensis seedlings for the first time, namely, PyPAL-1, PyPAL-2, and PyPAL-3. Our results indicated that the open-reading frames of PyPAL genes were 2184, 2157, and 2385 bp. Phylogenetic tree analysis revealed that PyPALs have high homology with other known PAL genes in other plants. In vitro enzymatic analysis showed that all three PyPAL recombinant proteins could catalyze the deamination of… More >

  • Open Access

    ARTICLE

    Selenium Differentially Regulates Flavonoid Accumulation and Antioxidant Capacities in Sprouts of Twenty Diverse Mungbean ( (L.) Wilczek) Genotypes

    Fenglan Zhao1, Jizhi Jin1, Meng Yang1, Franklin Eduardo Melo Santiago2, Jianping Xue1, Li Xu3,*, Yongbo Duan1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 611-625, 2024, DOI:10.32604/phyton.2024.048295

    Abstract

    Seed germination with selenium (Se) is promising for producing Se-biofortified foods. Mungbean (Vigna radiata (L.) Wilczek) sprout is freshly eaten as a salad dressed with sauce, making it superior for Se biofortification. Since the Se safety range for the human body is extremely narrow, it is imperative to evaluate the genotypic responses of mungbean sprouts to Se. This study evaluated the Se enrichment capacity and interaction with flavonoids and antioxidant systems in sprouts of 20 mungbean germplasms. Selenium treatment was done by immersing mungbean seeds in 20 μM sodium selenite solution for 8 h. Afterward, the biomass, Se amounts, flavonoid… More >

  • Open Access

    ARTICLE

    Identification and Transcriptional Regulation of CAMTA Genes in Liriodendron chinense

    Kaiyue Hong, Yasmina Radani, Teja Manda, Jinhui Chen, Liming Yang*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 413-425, 2024, DOI:10.32604/phyton.2024.047739

    Abstract This study explores CAMTA genes in the rare and endangered Chinese plant species, Liriodendron chinense. Despite the completion of whole-genome sequencing, the roles of CAMTA genes in calcium regulation and stress responses in this species remain largely unexplored. Within the L. chinense genome, we identified two CAMTA genes, Lchi09764 and Lchi222536, characterized by four functional domains: CG-1, TIG, ANK repeats, and IQ motifs. Our analyses, including phylogenetic investigations, cis-regulatory element analyses, and chromosomal location studies, aim to elucidate the defining features of CAMTA genes in L. chinense. Applying Weighted Gene Co-Expression Network Analysis (WGCNA), we explored the impact of CAMTAMore >

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