Refah Alotaibi¹, Hoda Rezk², Ahmed Elshahhat^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 3073-3103, 2024, DOI:10.32604/cmes.2024.050606

Abstract A new one-parameter Chris-Jerry distribution, created by mixing exponential and gamma distributions, is discussed in this article in the presence of incomplete lifetime data. We examine a novel generalized progressively hybrid censoring technique that ensures the experiment ends at a predefined period when the model of the test participants has a Chris-Jerry (CJ) distribution. When the indicated censored data is present, Bayes and likelihood estimations are used to explore the CJ parameter and reliability indices, including the hazard rate and reliability functions. We acquire the estimated asymptotic and credible confidence intervals of each unknown quantity. More >

Naif Alotaibi¹, A. S. Al-Moisheer², Ibrahim Elbatal¹, Mohammed Elgarhy^3,4, Ehab M. Almetwally^1,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2795-2823, 2024, DOI:10.32604/cmes.2024.049188

Abstract This article introduces a novel variant of the generalized linear exponential (GLE) distribution, known as the sine generalized linear exponential (SGLE) distribution. The SGLE distribution utilizes the sine transformation to enhance its capabilities. The updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability issues. The suggested model incorporates a hazard rate function (HRF) that may display a rising, J-shaped, or bathtub form, depending on its unique characteristics. This model includes many well-known lifespan distributions as separate sub-models. The suggested model is accompanied with a range of More >

DAN GUO¹, XI XIA^2,*, JIAN YANG^1,*

BIOCELL, Vol.48, No.7, pp. 1023-1036, 2024, DOI:10.32604/biocell.2024.051095

Abstract Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern medicine. In recent years, the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical requirements. This review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver failure. Here, we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver failure. Furthermore, we explored the challenges in transitioning More >

XULONG SUN^1,#, WENTAO DING^2,#, CHAO JIANG³, ZHIAN FANG^4,*

BIOCELL, Vol.48, No.7, pp. 1071-1079, 2024, DOI:10.32604/biocell.2024.050519

Abstract Introduction: Hepatocellular carcinoma (HCC), a prevalent malignancy, poses significant challenges with high tumor heterogeneity and poor prognosis. MicroRNAs (miRNAs) play a pivotal role in hepatocarcinogenesis. Although abnormalities in microRNA-557 (miR-557) expression have been implicated in various cancer types, its role in HCC remains unclear. Therefore, there is a need to explore the function of microRNA-557 in HCC. Methods: Candidate miRNAs were identified through screening in GSE108724 and GSE20077. Real-time PCR was employed to analyze the expression level of miR-557 in hepatoma cell lines and tissues. Cell viability and migration assays were applied to assess the… More > Graphic Abstract

JUN-FENG ZHAO^1,†, YI-RAN JIANG^2,†, TIAN-LIN GUO¹, YONG-QING JIAO^1,*, XUN WANG^1,*

BIOCELL, Vol.48, No.7, pp. 1011-1022, 2024, DOI:10.32604/biocell.2024.050120

Abstract Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the neurons. They are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of neurons. As the global population ages rapidly, increased people are being diagnosed with neurodegenerative diseases. It has been established that the onset of Alzheimer’s disease (AD) is closely linked with increasing age and its major pathological features include amyloid-beta plaques (Aβ), Tau hyperphosphorylation, Neurofibrillary tangles (NFTs), neuronal death as well as synaptic loss. The involvement of microglia is crucial… More >

JIAOE SHENG¹, ZUMIN YI², SANSHAN HE¹, QINGCHAO WU¹, XIA HUANG¹, GUOQING YAN¹, YUFANG DAI^1,*, LINCHONG SU^1,*

BIOCELL, Vol.48, No.7, pp. 1095-1104, 2024, DOI:10.32604/biocell.2024.028421

Abstract Introduction: Cholic acid (CA) is a natural steroid useful in treating chronic bronchitis and cholecystitis. On the other hand, its potential impact on osteoarthritis (OA) is unknown. Objective: Using an in vitro and in vivo osteoarthritis model, we sought to assess the chondroprotective properties of CA. Methods: We employed the Cell Counting Kit-8 to measure the impact of CA on chondrocyte activity to assess the toxicity of the cells. Multiple molecular biology experimental techniques were used to investigate potential signaling pathways that CA may use to prevent inflammation and give chondrocytes protection. Furthermore, how CA affects the OA… More >

Qian Tao, Guiqi Han, Bujin Ma, Hongmei Jia, Can Zhao, Wenshang Li, Zhuyun Yan^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1297-1310, 2024, DOI:10.32604/phyton.2024.051923

Abstract Fritillaria cirrhosa D. Don (Liliaceae) is an endangered perennial bulbous plant and its dry bulb is a valuable medicinal material with antitussive and expectorant effects. Nevertheless, lack of resources and expensive prices make it difficult to meet clinical needs. This study presents a regeneration system aimed at overcoming the challenge of inadequate supply in F. cirrhosa, focusing on: (1) callus induction, (2) bulblets and adventitious bud induction, and (3) artificial seed production. Callus development was achieved in 84.93% on Murashige and Skoog (MS) medium fortified with 1.0 mg·L picloram. The optimal medium for callus differentiation into regenerated… More >

Riwa Mahai¹, Rongpeng Liu¹, Xiaolang Du¹, Zejing Mu¹, Xiaoyun Wang^1,*, Jun Yuan^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1203-1219, 2024, DOI:10.32604/phyton.2024.051559

Abstract Rosaceae represents a vast and complex group of species, with its classification being intricate and contentious. The taxonomic placement of many species within this family has been a subject of ongoing debate. The study utilized the Illumina platform to sequence 19 plant species from 10 genera in the Rosaceae. The cp genomes, varying in size from 153,366 to 159,895 bp, followed the typical quadripartite organization consisting of a large single-copy (LSC) region (84,545 to 87,883 bp), a small single-copy (SSC) region (18,174 to 19,259 bp), and a pair of inverted repeat (IR) regions (25,310 to… More >

Jin Tao¹, Jiatai Tian¹, Dongmei Li¹, Jinlei Zhu², Qun Ma³, Zhiming Zhang¹, Jungang Chen⁴, Yipeng Liu⁵, Jianqiang Qian^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1129-1141, 2024, DOI:10.32604/phyton.2024.051405

Abstract Human activities and industrialization have significantly increased soil nutrients, such as nitrogen (N) and phosphorus (P), profoundly impacting the composition and structure of plant community, as well as the ecosystem functions, especially in nutrient-limited ecosystems. However, as the key propagule pool of perennial grasslands, how belowground bud bank and its relationship with aboveground vegetation respond to short-term changes in soil nutrients was still unclear. In this study, we conducted a short-term (2021–2022) soil fertilization experiment with N addition (10 g N m yr) and P addition (5 g N m yr) in the meadow steppe… More >

Zhengfeng Lai, Dongmei Lian, Shaoping Zhang, Yudong Ju, Bizhen Lin, Yunfa Yao, Songhai Wu, Jianji Hong, Zhou Li^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1143-1158, 2024, DOI:10.32604/phyton.2024.051207

Abstract The cytokinin oxidase/dehydrogenase (CKX) enzyme is essential for controlling the fluctuating levels of endogenous cytokinin (CK) and has a significant impact on different aspects of plant growth and development. Nonetheless, there is limited knowledge about CKX genes in tomato (Solanum lycopersicum L.). Here we performed genome-wide identification and analysis of nine SlCKX family members in tomatoes using bioinformatics tools. The results revealed that nine SlCKX genes were unevenly distributed on five chromosomes (Chr.1, Chr.4, Chr.8, Chr.10, and Chr.12). The amino acid length, isoelectric points, and molecular weight of the nine SlCKX proteins ranged from 453 to 553, 5.77… More >