MENNA AL-ADL^1,*, MAGDY M. YOUSSEF¹, AHMED EL-SEBAIE², SHERIF REFAAT³, AFAF EL-SAID⁴

Oncology Research, Vol.32, No.4, pp. 785-797, 2024, DOI:10.32604/or.2024.047021

Abstract Cytochromes P450 (CYPs) play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75% of the total metabolism of commercially available drugs, including chemotherapeutics. The gene expression and enzyme activity of CYPs are variable between individuals, which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics, as well as differences in the efficacy and toxicity of clinically used drugs. This research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients, as well as the clinical outcome after receiving cyclophosphamide chemotherapy. DNA… More > Graphic Abstract

REZA YADOLLAHVANDMIANDOAB^1,#, MEHRSA JALALIZADEH^1,#, FRANCIELE APARECIDA VECHIA DIONATO¹, KEINI BUOSI¹, PATRÍCIA A. F. LEME¹, LUCIANA S. B. DAL COL¹, CRISTIANE F. GIACOMELLI¹, ALEX DIAS ASSIS¹, NASIM BASHIRICHELKASARI¹, LEONARDO OLIVEIRA REIS^1,2,*

Oncology Research, Vol.32, No.4, pp. 597-605, 2024, DOI:10.32604/or.2024.045442

Abstract Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed that this technology can identify… More > Graphic Abstract

KUNLUN LI¹, DANDAN LI², BARBOD HAFEZ^3,*, MOUNIR M. SALEM BEKHIT⁴, YOUSEF A. BIN JARDAN⁴, FARS KAED ALANAZI⁴, EHAB I. TAHA⁴, SAYED H. AUDA⁴, FAIQAH RAMZAN^5,*, MUHAMMAD JAMIL⁶

Oncology Research, Vol.32, No.4, pp. 737-752, 2024, DOI:10.32604/or.2023.042925

Abstract Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that carries a substantial risk of morbidity and mortality. The MMP family assumes a crucial role in tumor invasion and metastasis. This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) through a comprehensive approach encompassing both computational and molecular analyses. STRING, Cytoscape, UALCAN, GEPIA, OncoDB, HPA, cBioPortal, GSEA, TIMER, ENCORI, DrugBank, targeted bisulfite sequencing (bisulfite-seq), conventional PCR, Sanger sequencing, and RT-qPCR based analyses were used in the present study to analyze MMP… More >

WEN GE^1,2,#, YA LI^1,2,#, YUTING RUAN^1,2, NINGXIA WU^1,2, PEI MA^3,4, TONGPENG XU^3,4, YONGQIAN SHU^3,4, YINGWEI WANG^1,2, WEN QIU^1,2, CHENHUI ZHAO^3,4,*

Oncology Research, Vol.32, No.4, pp. 625-641, 2024, DOI:10.32604/or.2023.031053

Abstract The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer (NSCLC). Although researchers have disclosed that interleukin 17 (IL-17) can increase matrix metalloproteinases (MMPs) induction causing NSCLC cell metastasis, the underlying mechanism remains unclear. In the study, we found that IL-17 receptor A (IL-17RA), p300, p-STAT3, Ack-STAT3, and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17. p300, STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3, Ack-STAT3 and MMP19 level as well as the cell migration and invasion. Mechanism investigation revealed that STAT3 and p300 bound… More > Graphic Abstract

Pankaj Saha^a, Gautam Biswas^a,b,*

Frontiers in Heat and Mass Transfer, Vol.2, No.3, pp. 1-5, 2011, DOI:10.5098/hmt.v2.3.3008

Abstract Detailed flow structure in turbulent flows through a rectangular channel containing built-in winglet type vortex generators have been analyzed by means of solutions of the full Navier-Stokes equations using a Large-Eddy Simulation (LES) technique. The Reynolds number of investigation is 6000. The geometry of interest consists of a rectangular channel with a built-in winglet pair on the bottom wall with common-flow-down arrangement. The winglet pair induces streamwise longitudinal vortices behind it. The vortices swirl the flow around the axis parallel to the mainstream direction and disrupt the growth of thermal boundary layer entailing enhancement of heat transfer. The influence of… More >

HAO LV¹, BO ZHU^1,2, DEGAO CHEN^1,2,*

BIOCELL, Vol.48, No.3, pp. 363-378, 2024, DOI:10.32604/biocell.2023.046367

Abstract Tumor-associated macrophages (TAMs) are emerging as targets for tumor therapy because of their primary role in promoting tumor progression. Several studies have been conducted to target TAMs by reducing their infiltration, depleting their numbers, and reversing their phenotypes to suppress tumor progression, leading to the development of drugs in preclinical and clinical trials. However, the heterogeneous characteristics of TAMs, including their ontogenetic and functional heterogeneity, limit their targeting. Therefore, in-depth exploration of the heterogeneity of TAMs, combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment. This review focuses on the heterogeneous ontogeny and… More >

SHAHID HUSSAIN^1,*, HABIB BOKHARI¹, XINGXING FAN², SHAUKAT IQBAL MALIK³, SUNDAS IJAZ¹, MUHAMMAD ADNAN SHEREEN⁴, AIMAN FATIMA³

BIOCELL, Vol.48, No.3, pp. 403-413, 2024, DOI:10.32604/biocell.2024.044801

Abstract The global incidence of lung cancer is marked by a considerably elevated mortality rate. MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration of gene regulation, and their dysregulation can precipitate dire consequences, notably cancer. Within this context, miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer, wherein their actions may either foster angiogenesis, cell proliferation, and metastasis, or counteract these processes. This comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung cancer. Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203, and miR-212, exhibit heightened expression… More >

Zhonghao Guo^*, Xinyue Xu, Xiangxian Chen

Computer Systems Science and Engineering, Vol.48, No.2, pp. 479-509, 2024, DOI:10.32604/csse.2023.043932

Abstract In software testing, the quality of test cases is crucial, but manual generation is time-consuming. Various automatic test case generation methods exist, requiring careful selection based on program features. Current evaluation methods compare a limited set of metrics, which does not support a larger number of metrics or consider the relative importance of each metric to the final assessment. To address this, we propose an evaluation tool, the Test Case Generation Evaluator (TCGE), based on the learning to rank (L2R) algorithm. Unlike previous approaches, our method comprehensively evaluates algorithms by considering multiple metrics, resulting in a more reasoned assessment. The… More >

Amr Ismail¹, Walid Hamdy^1,2, Aya M. Al-Zoghby³, Wael A. Awad³, Ahmed Ismail Ebada³, Yunyoung Nam⁴, Byeong-Gwon Kang^4,*, Mohamed Abouhawwash^5,6

Computer Systems Science and Engineering, Vol.48, No.2, pp. 273-285, 2024, DOI:10.32604/csse.2023.038192

Abstract Deep learning (DL) plays a critical role in processing and converting data into knowledge and decisions. DL technologies have been applied in a variety of applications, including image, video, and genome sequence analysis. In deep learning the most widely utilized architecture is Convolutional Neural Networks (CNN) are taught discriminatory traits in a supervised environment. In comparison to other classic neural networks, CNN makes use of a limited number of artificial neurons, therefore it is ideal for the recognition and processing of wheat gene sequences. Wheat is an essential crop of cereals for people around the world. Wheat Genotypes identification has… More >

Majid Tahmasebi Kohyani^a, Behzad Ghasemi^a, Ahmad Pasandideh Fard^b,*

Frontiers in Heat and Mass Transfer, Vol.3, No.2, pp. 1-6, 2012, DOI:10.5098/hmt.v3.2.3008

Abstract Natural convection heat transfer in a square cavity with a porous medium subjected to a uniform energy generation per unit volume is studied numerically in this paper. Temperature of the vertical walls is not equal but it is constant . There are two effective parameters in this condition that appear in the nondimensionalized equations and they are functions of temperature difference between hot and cold walls and energy generation in the porous medium. Nondimensionalized governing equations are obtained based on the Darcy model. a control volume approach is used for solving these equations. The effects of the variation of two… More >