Open Access
ARTICLE
Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion, and b-Catenin Expression in Non-Small Cell Lung Cancer Cells
Zhe-liang Liu*, Jiao Wu†, Lin-xian Wang‡, Jin-feng Yang†, Gao-ming Xiao*, Hui-ping Sun†, Yue-jun Chen*
* The First Department of Thoracic Surgery, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine,
Central South University, Changsha, China
† Department of Anesthesiology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine,
Central South University, Changsha, China
‡ Department of Clinical Laboratory, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine,
Central South University, Changsha, China
Oncology Research 2016, 24(3), 197-204. https://doi.org/10.3727/096504016X14648701447850
Abstract
Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, was found to be
involved in the development and progression of several tumors. However, the role of URG11 in human
non-small cell lung cancer (NSCLC) has not yet been determined. Therefore, the aim of the present study
was to explore the role of URG11 in human NSCLC. Our results found that URG11 was highly expressed in
human NSCLC tissues compared with matched normal lung tissues, and higher levels were found in NSCLC
cell lines in comparison to the normal lung cell line. Moreover, we also found that knockdown of URG11
significantly inhibited proliferation, migration/invasion of NSCLC cells, as well as suppressed tumor growth
in vivo. Furthermore, knockdown of URG11 suppressed the expression of β-catenin, c-Myc, and cyclin D1
in NSCLC cells. Taken together, the study reported here provided evidence that URG11 downregulation
suppresses proliferation, invasion, and β-catenin expression in NSCLC cells. Thus, URG11 may be a novel
potential therapeutic target for NSCLC.
Keywords
Cite This Article
APA Style
Liu, Z., Wu, J., Wang, L., Yang, J., Xiao, G. et al. (2016). Knockdown of upregulated gene 11 (URG11) inhibits proliferation, invasion, and b-catenin expression in non-small cell lung cancer cells. Oncology Research, 24(3), 197-204. https://doi.org/10.3727/096504016X14648701447850
Vancouver Style
Liu Z, Wu J, Wang L, Yang J, Xiao G, Sun H, et al. Knockdown of upregulated gene 11 (URG11) inhibits proliferation, invasion, and b-catenin expression in non-small cell lung cancer cells. Oncol Res. 2016;24(3):197-204 https://doi.org/10.3727/096504016X14648701447850
IEEE Style
Z. Liu et al., "Knockdown of Upregulated Gene 11 (URG11) Inhibits Proliferation, Invasion, and b-Catenin Expression in Non-Small Cell Lung Cancer Cells," Oncol. Res., vol. 24, no. 3, pp. 197-204. 2016. https://doi.org/10.3727/096504016X14648701447850