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The tumor suppressor role and ceRNA network of miR-1294 in cancer

YUNAN MAO1,#, JINZE SHEN1,#, LI FANG2, FENG ZHU1,*, SHIWEI DUAN1,*

1 Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, 310000, China
2 Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China

* Corresponding Authors: Feng Zhu, email; Shiwei Duan, email
# These authors contributed equally to this work

Oncology Research 2023, 31(1), 1-12. https://doi.org/10.32604/or.2022.027359

Abstract

miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer.

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APA Style
MAO, Y., SHEN, J., FANG, L., ZHU, F., DUAN, S. (2023). The tumor suppressor role and cerna network of mir-1294 in cancer. Oncology Research, 31(1), 1-12. https://doi.org/10.32604/or.2022.027359
Vancouver Style
MAO Y, SHEN J, FANG L, ZHU F, DUAN S. The tumor suppressor role and cerna network of mir-1294 in cancer. Oncol Res. 2023;31(1):1-12 https://doi.org/10.32604/or.2022.027359
IEEE Style
Y. MAO, J. SHEN, L. FANG, F. ZHU, and S. DUAN "The tumor suppressor role and ceRNA network of miR-1294 in cancer," Oncol. Res., vol. 31, no. 1, pp. 1-12. 2023. https://doi.org/10.32604/or.2022.027359



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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