Open Access

REVIEW

The tumor suppressor role and ceRNA network of miR-1294 in cancer

YUNAN MAO^1,#, JINZE SHEN^1,#, LI FANG², FENG ZHU^1,*, SHIWEI DUAN^1,*

1 Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, 310000, China
2 Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China

* Corresponding Authors: Feng Zhu, ; Shiwei Duan,
# These authors contributed equally to this work

Oncology Research 2023, 31(1), 1-12. https://doi.org/10.32604/or.2022.027359

Received 22 October 2022; Accepted 31 January 2023; Issue published 01 March 2023

Abstract

miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer.

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Keywords

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