Home / Journals / OR / Vol.31, No.1, 2023
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  • Open AccessOpen Access

    REVIEW

    The tumor suppressor role and ceRNA network of miR-1294 in cancer

    YUNAN MAO1,#, JINZE SHEN1,#, LI FANG2, FENG ZHU1,*, SHIWEI DUAN1,*
    Oncology Research, Vol.31, No.1, pp. 1-12, 2023, DOI:10.32604/or.2022.027359 - 01 March 2023
    Abstract miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work More >

  • Open AccessOpen Access

    ARTICLE

    Changes of protein expression during tumorosphere formation of small cell lung cancer circulating tumor cells

    SANDRA STICKLER1, BARBARA RATH1, MAXIMILIAN HOCHMAIR2, CLEMENS LANG3, LUKAS WEIGL4, GERHARD HAMILTON1,*
    Oncology Research, Vol.31, No.1, pp. 13-22, 2023, DOI:10.32604/or.2022.027281 - 01 March 2023
    Abstract Small cell lung cancer (SCLC) is frequently disseminated and has a dismal prognosis with survival times of approximately two years. This cancer responds well to initial chemotherapy but recurs within a short time as a globally chemoresistant tumor. Circulating tumor cells (CTCs) are held responsible for metastasis, the extremely high numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell lines. These CTCs are distinguished by the spontaneous formation of large spheroids, termed tumorospheres, in regular tissue culture. These contain quiescent and hypoxic cells in their interior and are associated… More >

  • Open AccessOpen Access

    ARTICLE

    H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus

    YI-NONG CHEN1,#, YING-LIN CHEN1,#, WAN-MING CHEN2,3, MINGCHIH CHEN2,3, BEN-CHANG SHIA2,3, JENQ-YUH KO1,4, SZU-YUAN WU2,3,5,6,7,8,9,10,11,*
    Oncology Research, Vol.31, No.1, pp. 23-34, 2023, DOI:10.32604/or.2022.028449 - 01 March 2023
    Abstract This study aimed to examine the association between the use of H1-antihistamines (AHs) and head and neck cancer (HNC) risk in patients with type 2 diabetes mellitus (T2DM). Data from the National Health Insurance Research Database of Taiwan were analyzed for the period from 2008 to 2018. A propensity-score-matched cohort of 54,384 patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox proportional hazards regression. The results showed that the risk of HNC was significantly lower in AH users (adjusted hazard ratio: 0.55, 95% CI: 0.48 to More >

  • Open AccessOpen Access

    ARTICLE

    Identification and verification of aging-related lncRNAs for prognosis prediction and immune microenvironment in patients with head and neck squamous carcinoma

    QING GAO1,#, YUJING SHI2,#, YUANYUAN SUN1,#, SHU ZHOU1, ZEYUAN LIU3, XINCHEN SUN1,*, XIAOKE DI1,*
    Oncology Research, Vol.31, No.1, pp. 35-61, 2023, DOI:10.32604/or.2022.028193 - 01 March 2023
    Abstract Aging is highly associated with tumor formation and progression. However, little research has explored the association of aging-related lncRNAs (ARLs) with the prognosis and tumor immune microenvironment (TIME) of head and neck squamous cell carcinoma (HNSCC). RNA sequences and clinicopathological data of HNSCC patients and normal subjects were downloaded from The Cancer Genome Atlas. In the training group, we used Pearson correlation, univariate Cox regression, least absolute shrinkage/selection operator regression analyses, and multivariate Cox regression to build a prognostic model. In the test group, we evaluated the model. Multivariate Cox regression was done to screen… More >

  • Open AccessOpen Access

    ARTICLE

    Has_circ_0000069 expression in breast cancer and its influences on prognosis and cellular activities

    GANG WANG#, MINGPING QIAN#, WEI JIAN, JUHANG CHU, YIXIANG HUANG*
    Oncology Research, Vol.31, No.1, pp. 63-70, 2023, DOI:10.32604/or.2022.028168 - 01 March 2023
    Abstract Circular RNA (circRNA), as a newly discovered non-coding RNA with important regulatory potential, is closely related to the occurrence and progression of various tumors. This study aimed to investigate has_circ_0000069 expression in breast cancer and its influence on cellular activities. Using real-time quantitative polymerase chain reaction, has_circ_0000069 levels were measured in 137 pairs of tissue specimens, as well as cancer cell lines. The cellular activities of cell lines were determined by cell counting kit-8 (CCK-8) and Transwell assays. The potential targeting miRNAs were predicted and verified using an online database and dual-luciferase reporter assay. Has_circ_0000069… More >

  • Open AccessOpen Access

    ARTICLE

    Thioredoxin domain-containing protein 9 protects cells against UV-B-provoked apoptosis via NF-κB/p65 activation in cutaneous squamous cell carcinoma

    ZHIXUN XIAO1, QIUYUN XU1, HAIQING WANG1, XIAOTONG ZHOU2, YANTING ZHU1, CHENGBEI BAO1, LIHONG CHEN1, PENG ZHANG1, MIN LIN1, CHAO JI1,*, TING GONG3,*
    Oncology Research, Vol.31, No.1, pp. 71-82, 2023, DOI:10.32604/or.2022.028075 - 01 March 2023
    Abstract Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most common malignancy worldwide. Thioredoxin (TXN) domain-containing protein 9 (TXNDC9) is a member of the TXN family that is important in cell differentiation. However, the biological function of this protein in cancer, particularly cSCC, is still unknown. In the present study, our experiments revealed the protective effects of TXNDC9 on UV-B-irritated cSCC cells. The initial findings showed that TXNDC9 is significantly upregulated in cSCC tissue and cells compared to normal skin tissue and keratinocytes. UV-B radiation robustly induces the expression of More >

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