Open Access
REVIEW
YUNAN MAO1,#, JINZE SHEN1,#, LI FANG2, FENG ZHU1,*, SHIWEI DUAN1,*
Oncology Research, Vol.31, No.1, pp. 1-12, 2023, DOI:10.32604/or.2022.027359
Abstract miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to
be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation,
migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR,
RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression
of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC,
PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and… More >
Open Access
ARTICLE
SANDRA STICKLER1, BARBARA RATH1, MAXIMILIAN HOCHMAIR2, CLEMENS LANG3, LUKAS WEIGL4, GERHARD HAMILTON1,*
Oncology Research, Vol.31, No.1, pp. 13-22, 2023, DOI:10.32604/or.2022.027281
Abstract Small cell lung cancer (SCLC) is frequently disseminated and has a dismal prognosis with survival times of
approximately two years. This cancer responds well to initial chemotherapy but recurs within a short time as a
globally chemoresistant tumor. Circulating tumor cells (CTCs) are held responsible for metastasis, the extremely high
numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell lines. These CTCs are
distinguished by the spontaneous formation of large spheroids, termed tumorospheres, in regular tissue culture. These
contain quiescent and hypoxic cells in their interior and are associated with high chemoresistance compared to… More >
Open Access
ARTICLE
YI-NONG CHEN1,#, YING-LIN CHEN1,#, WAN-MING CHEN2,3, MINGCHIH CHEN2,3, BEN-CHANG SHIA2,3, JENQ-YUH KO1,4, SZU-YUAN WU2,3,5,6,7,8,9,10,11,*
Oncology Research, Vol.31, No.1, pp. 23-34, 2023, DOI:10.32604/or.2022.028449
Abstract This study aimed to examine the association between the use of H1-antihistamines (AHs) and head and neck
cancer (HNC) risk in patients with type 2 diabetes mellitus (T2DM). Data from the National Health Insurance Research
Database of Taiwan were analyzed for the period from 2008 to 2018. A propensity-score-matched cohort of 54,384
patients each in the AH user and nonuser groups was created and analyzed using Kaplan-Meier method and Cox
proportional hazards regression. The results showed that the risk of HNC was significantly lower in AH users
(adjusted hazard ratio: 0.55, 95% CI: 0.48 to 0.64) and the incidence rate… More >
Open Access
ARTICLE
QING GAO1,#, YUJING SHI2,#, YUANYUAN SUN1,#, SHU ZHOU1, ZEYUAN LIU3, XINCHEN SUN1,*, XIAOKE DI1,*
Oncology Research, Vol.31, No.1, pp. 35-61, 2023, DOI:10.32604/or.2022.028193
Abstract Aging is highly associated with tumor formation and progression. However, little research has explored the
association of aging-related lncRNAs (ARLs) with the prognosis and tumor immune microenvironment (TIME) of
head and neck squamous cell carcinoma (HNSCC). RNA sequences and clinicopathological data of HNSCC patients
and normal subjects were downloaded from The Cancer Genome Atlas. In the training group, we used Pearson
correlation, univariate Cox regression, least absolute shrinkage/selection operator regression analyses, and multivariate
Cox regression to build a prognostic model. In the test group, we evaluated the model. Multivariate Cox regression
was done to screen out independent prognostic factors, with… More >
Open Access
ARTICLE
GANG WANG#, MINGPING QIAN#, WEI JIAN, JUHANG CHU, YIXIANG HUANG*
Oncology Research, Vol.31, No.1, pp. 63-70, 2023, DOI:10.32604/or.2022.028168
Abstract Circular RNA (circRNA), as a newly discovered non-coding RNA with important regulatory potential, is closely
related to the occurrence and progression of various tumors. This study aimed to investigate has_circ_0000069 expression
in breast cancer and its influence on cellular activities. Using real-time quantitative polymerase chain reaction,
has_circ_0000069 levels were measured in 137 pairs of tissue specimens, as well as cancer cell lines. The cellular
activities of cell lines were determined by cell counting kit-8 (CCK-8) and Transwell assays. The potential targeting
miRNAs were predicted and verified using an online database and dual-luciferase reporter assay. Has_circ_0000069
was highly expressed in breast… More >
Open Access
ARTICLE
ZHIXUN XIAO1, QIUYUN XU1, HAIQING WANG1, XIAOTONG ZHOU2, YANTING ZHU1, CHENGBEI BAO1, LIHONG CHEN1, PENG ZHANG1, MIN LIN1, CHAO JI1,*, TING GONG3,*
Oncology Research, Vol.31, No.1, pp. 71-82, 2023, DOI:10.32604/or.2022.028075
Abstract Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most
common malignancy worldwide. Thioredoxin (TXN) domain-containing protein 9 (TXNDC9) is a member of the
TXN family that is important in cell differentiation. However, the biological function of this protein in cancer,
particularly cSCC, is still unknown. In the present study, our experiments revealed the protective effects of TXNDC9
on UV-B-irritated cSCC cells. The initial findings showed that TXNDC9 is significantly upregulated in cSCC tissue
and cells compared to normal skin tissue and keratinocytes. UV-B radiation robustly induces the expression of
TXNDC9, and UV-B-induced cSCC cell… More >