Home / Journals / OR / Vol.25, No.2, 2017
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  • Open AccessOpen Access

    ARTICLE

    Knockdown of Long Noncoding RNA FTX Inhibits Proliferation, Migration, and Invasion in Renal Cell Carcinoma Cells

    Xiangfei He, Fuguang Sun, Fengfu Guo, Kai Wang, Yisheng Gao, Yanfei Feng, Bin Song, Wenzhi Li, Yang Li
    Oncology Research, Vol.25, No.2, pp. 157-166, 2017, DOI:10.3727/096504016X14719078133203
    Abstract Renal cell carcinoma (RCC) is one of the most common kidney cancers worldwide. Although great progressions have been made in the past decades, its morbidity and lethality remain increasing. Long noncoding RNAs (lncRNAs) are demonstrated to play significant roles in the tumorigenesis. This study aimed to investigate the detailed roles of lncRNA FTX in RCC cell proliferation and metastasis. Our results showed that the transcript levels of FTX in both clinical RCC tissues and the cultured RCC cells were significantly upregulated and associated with multiple clinical parameters of RCC patients, including familial status, tumor sizes, More >

  • Open AccessOpen Access

    ARTICLE

    Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells

    Jie Huang*, Li Guo
    Oncology Research, Vol.25, No.2, pp. 167-176, 2017, DOI:10.3727/096504016X14732772150307
    Abstract Sex-determining region Y (SRY)-box 9 (SOX9) is a member of the SOX transcription factor family. Increasing evidence has reported that SOX9 plays different roles in various types of malignancies. However, the role of SOX9 in papillary thyroid cancer (PTC) is still unclear. The aim of this study was to investigate the role of SOX9 in PTC. Our results showed that SOX9 was upregulated in PTC tissues and cell lines. In addition, knockdown of SOX9 significantly inhibited PTC proliferation, colony formation, migration, and invasion, as well as epithelial–mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells. More >

  • Open AccessOpen Access

    ARTICLE

    CXCL5 Plays a Promoting Role in Osteosarcoma Cell Migration and Invasion in Autocrine- and Paracrine-Dependent Manners

    Hongsheng Dang, Wuzhou Wu, Bo Wang, Cao Cui, Juwei Niu, Jie Chen, Ziqiu Chen, Yi Liu
    Oncology Research, Vol.25, No.2, pp. 177-186, 2017, DOI:10.3727/096504016X14732772150343
    Abstract CXCL5, a CXC-type chemokine, is an important attractant for granulocytic immune cells by binding to its receptor CXCR2. Recently, CXCL5/CXCR2 has been found to play an oncogenic role in many human cancers. However, the exact role of CXCL5 in osteosarcoma cell migration and invasion has not been revealed. Here we found that the protein expression of CXCL5 was significantly increased in osteosarcoma tissues compared with that in matched adjacent nontumor tissues. Moreover, the expression of CXCL5 was significantly associated with advanced clinical stage and metastasis. Further investigation showed that the CXCL5 expression levels were also… More >

  • Open AccessOpen Access

    ARTICLE

    miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R

    Haiyang Wang*, Chongyang Tang*, Meng Na*, Wei Ma*, Zhenfeng Jiang*, Yifei Gu*, Guizhen Ma, Haitao Ge*, Hong Shen*, Zhiguo Lin*
    Oncology Research, Vol.25, No.2, pp. 187-194, 2017, DOI:10.3727/096504016X14732772150389
    Abstract Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a in human glioma. We found that miR-422a was downregulated in glioma tissues. We also demonstrated that expression of miR-422a in glioma cells markedly suppressed cell proliferation, migration, and invasion. In addition, we identified insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) as inhibitory targets of miR-422a in glioma cells. We established that More >

  • Open AccessOpen Access

    ARTICLE

    Ror2, a Developmentally Regulated Kinase, Is Associated With Tumor Growth, Apoptosis, Migration, and Invasion in Renal Cell Carcinoma

    Chun-ming Yang*, Shan Ji, Yan Li, Li-ye Fu, Tao Jiang, Fan-dong Meng
    Oncology Research, Vol.25, No.2, pp. 195-205, 2017, DOI:10.3727/096504016X14732772150424
    Abstract Renal cell carcinoma (RCC) represents one of the most resistant tumors to radiation and chemotherapy. Current therapies for RCC patients are inefficient due to the lack of diagnostic and therapeutic markers. The expression of novel tumor-associated kinases has the potential to dramatically shape tumor cell behavior. Identifying tumor-associated kinases can lend insight into patterns of tumor growth and characteristics. In the present study, we investigated the receptor tyrosine kinase-like orphan receptor 2 (Ror2), a new tumor-associated kinase, in RCC primary tumors and cell lines. Knockdown of Ror2 expression in RCC cells with specific shRNA significantly More >

  • Open AccessOpen Access

    ARTICLE

    Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells

    Ziliang Zhou*†1, Lijie Zhou*‡1, Fangfang Jiang*, Binghui Zeng*, Changbo Wei*, Wei Zhao*, Dongsheng Yu*
    Oncology Research, Vol.25, No.2, pp. 207-214, 2017, DOI:10.3727/096504016X14732772150460
    Abstract Previous studies have shown that miR-222 targets the p53 upregulated modulator of apoptosis (PUMA) to regulate cell biological behavior in some human malignancies. We hypothesized that there was a negative regulation, which might induce apoptosis, between miR-222 and PUMA in adenoid cystic carcinoma (ACC). In this study, the expression levels of miR-222 and the PUMA gene after transfection with antisense miR-222 (As-miR-222) were evaluated by RT-PCR and Western blot assays. Cell proliferation and migratory abilities were detected by CCK-8 and Transwell assays. Cell cycle and apoptosis were analyzed by flow cytometry. Our results showed that, More >

  • Open AccessOpen Access

    ARTICLE

    miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2

    Xiangrui Meng*1, Xiaoqi Chen†1, Peng Lu, Wang Ma*, Dongli Yue*, Lijie Song*, Qingxia Fan*
    Oncology Research, Vol.25, No.2, pp. 215-223, 2017, DOI:10.3727/096504016X14732772150541
    Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant cancers with high mortality around the world. However, the regulatory mechanism of ESCC carcinogenesis is not completely known. Here we demonstrate the novel role of miR-202 in regulating ESCC cell apoptosis. The analysis of data obtained from the GEO database showed that the expression of miR-202 is aberrantly decreased in tumor tissue from ESCC patients and cultured ESCC cell lines. After transfection with miR-202 mimic or inhibitor, the apoptotic capacity of ESCC cells was significantly increased by miR-202 overexpression but reduced by miR-202… More >

  • Open AccessOpen Access

    ARTICLE

    Knockdown of Collagen Triple Helix Repeat Containing 1 (CTHRC1) Inhibits Epithelial–Mesenchymal Transition and Cellular Migration in Glioblastoma Cells

    Jianpeng Liu*, Wei Li, Shunshun Liu*, Xu Zheng*, Lin Shi*, Weitao Zhang*, Hongfa Yang*
    Oncology Research, Vol.25, No.2, pp. 225-232, 2017, DOI:10.3727/096504016X14732772150587
    Abstract Collagen triple helix repeat containing 1 (CTHRC1), an extracellular matrix-related protein, has been found to be upregulated in many solid tumors and contributes to tumorigenesis. We found that CTHRC1 is overexpressed in glioblastoma tissues and cells. By using the technique of RNA interference, the expression of CTHRC1 in the human glioblastoma U-87MG cell line was downregulated, and the proliferation and migration of U-87MG cells were examined. The results showed that the knockdown of CTHRC1 exerts inhibitory effects on the proliferation and migration ability of U-87MG cells. Knockdown of CTHRC1 expression in U-87MG cells resulted in More >

  • Open AccessOpen Access

    ARTICLE

    Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB

    Min Li*†, Mao Zhang*, Zhi-lang Zhang*, Ning Liu*, Xiao-yu Han*, Qin-cheng Liu*, Wei-jun Deng, Cai-xian Liao*
    Oncology Research, Vol.25, No.2, pp. 233-239, 2017, DOI:10.3727/096504016X14742891049073
    Abstract Hepatocellular carcinoma (HCC) is highly resistant to traditional chemotherapeutic approaches, which causes difficulty in the development of effective drugs for the treatment of HCC. Berberine, a major ingredient of Rhizoma coptidis, is a natural alkaloid used in traditional Chinese medicine. Berberine exhibits potent antitumor activity against HCC due to its high efficiency and low toxicity. In the present study, we found that berberine sensitized HepG cells to NF-kB-mediated apoptosis. Berberine exhibited a significant antiproliferation effect on the HepG2 cells and promoted apoptosis. Both qRT-PCR and immunofluorescence staining revealed that berberine reduced the NF-kB p65 levels in More >

  • Open AccessOpen Access

    ARTICLE

    Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo

    Junkai Chang*1, Weibo Xu*1, Guangchao Liu, Xinyi Du*, Xiaodong Li*
    Oncology Research, Vol.25, No.2, pp. 241-248, 2017, DOI:10.3727/096504016X14742891049118
    Abstract Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Gli1. Furthermore, we found More >

  • Open AccessOpen Access

    ARTICLE

    Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells

    Jin Zhang, Danjie Zhang, Liangzhang Sun
    Oncology Research, Vol.25, No.2, pp. 249-257, 2017, DOI:10.3727/096504016X693164
    Abstract Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes (DUBs), plays an essential role in the development of human carcinoma. However, to the best of our knowledge, the role of USP14 in esophageal squamous cell carcinoma (ESCC) is unknown. In the current study, we investigated the expression and role of USP14 in ESCC. Our results showed that the level of USP14 was significantly increased in ESCC tissues and cell lines. Downregulation of USP14 significantly inhibited ESCC cell proliferation and ESCC tumor growth in nude mice. Downregulation of USP14 also suppressed the migration/invasion in ESCC More >

  • Open AccessOpen Access

    ARTICLE

    Knockdown of Long Noncoding RNA NR_026689 Inhibits Proliferation and Invasion and Increases Apoptosis in Ovarian Carcinoma HO-8910PM Cells

    Xin Zhang*, Shaowen Li, Chunli Dong, Xiuying Xie*, Yunping Zhang*
    Oncology Research, Vol.25, No.2, pp. 259-265, 2017, DOI:10.3727/096504016X14732503870766
    Abstract Ovarian cancer is one of the leading causes of gynecological cancer-related deaths worldwide. We investigated the role of a newly discovered long noncoding RNA, NR_026689, in cell proliferation, metastasis, and apoptosis in ovarian cancer cells. Our results showed that NR_026689 was overexpressed in both clinical ovarian cancer patients and cultured ovarian cancer cells. Knockdown of NR_026689 in HO-8910PM cells significantly decreased the cell proliferative rate and the ability to form colonies. Transwell assays revealed that depletion of NR_026689 suppressed cell migration ability by 68% and cell invasive capacity by 71% in HO-8910PM cells. Moreover, specific More >

  • Open AccessOpen Access

    ARTICLE

    Overexpression of miR-140 Inhibits Proliferation of Osteosarcoma Cells via Suppression of Histone Deacetylase 4

    Qianren Xiao*1, Lu Huang†1, Zhongzu Zhang‡1, Xiang Chen*, Jiaquan Luo*, Zhanmin Zhang§, Shaoqing Chen§, Yong Shu*, Zhimin Han*, Kai Cao*
    Oncology Research, Vol.25, No.2, pp. 267-275, 2017, DOI:10.3727/096504016X14732510786564
    Abstract miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and More >

  • Open AccessOpen Access

    ARTICLE

    miR-4262 Promotes Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting KLF6 and KLF15

    Ke Wang, Yu Ren, Yang Liu, Jian Zhang, Jian-jun He
    Oncology Research, Vol.25, No.2, pp. 277-283, 2017, DOI:10.3727/096504016X14732514133203
    Abstract miRNAs have been shown to be involved in breast cancer growth and progression. miR-4262 is a potential tumor promoter in human cancers. In this study, we first investigated the role of miR-4262 in the proliferation and invasion of human breast cancer cells. Our results showed that, compared with the adjacent tissues and MCF-10A normal breast epithelial cells, miR-4262 was markedly increased in the breast cancer tissues and five cell lines, including MDA-MB-231, MDA-MB-468, MDA-MB-435, SKBR3, and MCF-7. Then the miR- 4262 mimic or oligo anta-miR-4262 was transfected into MDA-MB-231 and MCF-7 breast cancer cell lines.… More >

  • Open AccessOpen Access

    ARTICLE

    CKLF-Like MARVEL Transmembrane Domain-Containing Member 3 (CMTM3) Inhibits the Proliferation and Tumorigenisis in Hepatocellular Carcinoma Cells

    Wujun Li*, Shaobo Zhang
    Oncology Research, Vol.25, No.2, pp. 285-293, 2017, DOI:10.3727/096504016X14732523471442
    Abstract The CKLF-like MARVEL transmembrane domain-containing 3 (CMTM3), a member of the CMTM family, was found in several human tumors and plays an important role in the development and progression of tumors. However, the role of CMTM3 in hepatocellular carcinoma (HCC) remains largely unknown. Thus, in the present study, we explored its expression pattern in human HCC cell lines, as well as its functions in HCC cells. Our results demonstrated that the expression of CMTM3 is lowly expressed in HCC cell lines. In vitro, we found that overexpression of CMTM3 obviously inhibited the proliferation, invasion, and More >

  • Open AccessOpen Access

    ARTICLE

    Intratumoral Photodynamic Therapy With Newly Synthesized Pheophorbide a in Murine Oral Cancer

    Mee-Young Ahn*1, Hyo-Eun Yoon†1, Seong-Yong Moon, Yong-Chul Kim§, Jung-Hoon Yoon
    Oncology Research, Vol.25, No.2, pp. 295-304, 2017, DOI:10.3727/096504016X14732527645922
    Abstract Photodynamic therapy (PDT) is a therapeutic alternative for malignant tumors that uses a photosensitizer. Our group recently synthesized photosensitizer pheophorbide a (Pa) from chlorophyll-a. The present study investigated the therapeutic effect of PDT using intratumoral administration of the synthetic photosensitizer Pa in an in vivo murine oral squamous cell carcinoma (OSCC) animal model. Pa accumulation was measured using the fluorescence spectrum and imaging in living C3H mice. Intratumoral treatment of Pa-PDT (IT Pa-PDT) significantly inhibited the growth of transplanted OSCC cells. Histopathological examination of tumor tissues showed that PCNA expression was significantly decreased, while TUNEL-stained… More >

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