IQGAP3 promotes the progression of glioma as an immune and prognostic marker
XIAOFENG GAO1,2,3,4, JUANJUAN GE3, XUZHENG GAO1,3, NA MEI1,3, YANTING SU3, SHIGANG SHAN3, WENBIN QIAN3, JIANGHENG GUAN5, ZHENWANG ZHANG1,3,*, LONG WANG2,3,4,*
Oncology Research, Vol.32, No.4, pp. 659-678, 2024, DOI:10.32604/or.2023.046712
- 20 March 2024
(This article belongs to the Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Background: IQGAP3 plays a crucial role in regulating cell proliferation, division, and cytoskeletal organization. Abnormal expression of IQGAP3 has been linked to various tumors, but its function in glioma is not well understood. Methods: Various methods, including genetic differential analysis, single-cell analysis, ROC curve analysis, Cox regression, Kaplan-Meier analysis, and enrichment analysis, were employed to analyze the expression patterns, diagnostic potential, prognostic implications, and biological processes involving IQGAP3 in normal and tumor tissues. The impact of IQGAP3 on immune infiltration and the immune microenvironment in gliomas was evaluated using immunofluorescence. Additionally, the cBioPortal database was used… More >
Graphic Abstract