Open Access

REVIEW

EDUARDO ALVARADO-ORTIZ^1,2, MIGUEL ANGEL SARABIA-SáNCHEZ^3,*
Oncology Research, Vol.33, No.8, pp. 1803-1818, 2025, DOI:10.32604/or.2025.065953 - 18 July 2025
（This article belongs to the Special Issue: Direct and Paracrine Interactions within the Tumor or Tumor and its  Microenvironment)
Abstract The tumor microenvironment (TME) is characterized by a symbiosis between cancer cells and the immune cells. The scarcity of oxygen generates hostility that forces cancer cells to alter their biological features in solid tumors. In response to low oxygen availability, the Hypoxia Inducible Factors (HIF-1/2/3α) act as metabolic mediators, producing extracellular metabolites in the tumor microenvironment that influence the immune cells. The modulation of lactate and adenosine on immune evasion has been widely described; however, under hypoxic conditions, it has been barely addressed. Evidence has demonstrated an interplay between cancer and the immune cells, and More >

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FLáVIA ALVES VERZA^1,#,*, GUILHERME CARVALHO DA SILVA^2,#, FELIPE GARCIA NISHIMURA²
Oncology Research, Vol.33, No.8, pp. 1819-1834, 2025, DOI:10.32604/or.2025.065755 - 18 July 2025
（This article belongs to the Special Issue: Drug Targets in Oncology: Mechanisms, Challenges, and Innovations)
Abstract Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, More >

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VINOTHKUMAR VEERASAMY¹, VEERAVARMAL VEERAN², SIDDAVARAM NAGINI^1,3,*
Oncology Research, Vol.33, No.8, pp. 1835-1860, 2025, DOI:10.32604/or.2025.064010 - 18 July 2025
Abstract The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway is one of the most frequently dysregulated signaling networks in oral squamous cell carcinoma (OSCC). Although the tumor microenvironment (TME) and epigenetic modifiers are recognized to play a pivotal role in aberrant activation of the PI3K/AKT pathway in OSCC, the available evidence is fragmentary and a comprehensive analysis is warranted. This review evaluates the intricate mechanisms by which various components of the TME facilitate proliferation, apoptosis evasion, invasion, migration, angiogenesis, metastasis, as well as therapy resistance in OSCC through activation of PI3K/AKT signalling. The review has also More >

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REVIEW

YUFENG WANG¹, HUIFENG DANG¹, QIANQIAN WANG¹, SHUXIAO WU¹, LEI HAN¹, XU LUO¹, YINGXIA TIAN^1,*, HAILIN TANG^2,*
Oncology Research, Vol.33, No.8, pp. 1861-1874, 2025, DOI:10.32604/or.2025.063716 - 18 July 2025
Abstract This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase (PDP) in malignant tumors and its potential mechanisms. Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells, and potentially promotes tumor. Research has comprehensively explored the structural-functional characteristics of PDP, its metabolic regulatory mechanisms, and its role in various types of malignant tumors. Nevertheless, several questions still exist regarding its potential mechanisms within acetylation, phosphorylation, hypoxia, immune infiltration, mitochondrial metabolism, drug resistance, oxidative phosphorylation, and tumor prognosis. This article intends to More >

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REVIEW

Wenfei Luo^1,#, Dingming Song^2,#, Yibo He³, Judong Song^4,*, Yunzhen Ding^5,*
Oncology Research, Vol.33, No.8, pp. 1875-1893, 2025, DOI:10.32604/or.2025.063843 - 18 July 2025
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Malignant melanoma, characterized by its high metastatic potential and resistance to conventional therapies, presents a major challenge in oncology. This review explores the current status and advancements in tumor vaccines for melanoma, focusing on peptide, DNA/RNA, dendritic cell, tumor cell, and neoantigen-based vaccines. Despite promising results, significant challenges remain, including the immunosuppressive tumor microenvironment, patient heterogeneity, and the need for more effective antigen presentation. Recent strategies, such as combining vaccines with immune checkpoint inhibitors (ICIs), aim to counteract immune evasion and enhance T cell responses. Emerging approaches, including personalized neoantigen vaccines and the use of More >

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Madeline Keane¹, Natalia Wojciechowska², Lindsay Zumwalt^1,*, Emilie Sandfeld³, Alejandra Dominguez¹, Jason Wang², Anish Ray²
Oncology Research, Vol.33, No.8, pp. 1895-1908, 2025, DOI:10.32604/or.2025.065547 - 18 July 2025
（This article belongs to the Special Issue: Cutting-edge strategies for pediatric solid tumors: diagnostic and therapeutic insights)
Abstract Background: Precision medicine is an emerging approach for treating pediatric cancer due to its ability to target tumor-specific genetic drivers rather than provide broad and aggressive treatments. The study aimed to outline the establishment and impact of a Precision Medicine Clinic (PMC) in the setting of pediatric oncology, with the objective of offering targeted treatment options within the institution and creating a scalable model for adoption by other healthcare systems to achieve a wider impact. Methods: Recognizing this need for an individualized approach to treating patients, Cook Children’s Medical Center (CCMC) established a multidisciplinary molecular… More >

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JONG-HYUK AHN¹, JIN WOOK YI^2,3,*
Oncology Research, Vol.33, No.8, pp. 1909-1931, 2025, DOI:10.32604/or.2025.065847 - 18 July 2025
Abstract Background: With growing interest in space exploration, understanding microgravity’s impact on human health is essential. This study aims to investigate gene expression changes and migration and invasion potential in five thyroid-related cell lines cultured under simulated microgravity. Methods: Five thyroid-related cell lines—normal thyrocytes (Nthy-ori 3-1), papillary thyroid cancer (PTC) cells (SNU-790, TPC-1), poorly differentiated thyroid cancer cell (BCPAP), and anaplastic thyroid cancer cell (SNU-80)—were cultured under simulated microgravity (10⁻³ g) using a clinostat. Differentially expressed genes (DEGs) were analyzed using cDNA microarray, followed by functional annotation and assessment of aggressiveness via Transwell migration and invasion assays.… More >

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YU ZHANG^1,2, QINGKUN WANG², YUE HAN², JUNJIE PIAO^2,*, XIUYING JIN^1,2,*
Oncology Research, Vol.33, No.8, pp. 1933-1945, 2025, DOI:10.32604/or.2025.063395 - 18 July 2025
（This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
Abstract Background: Colorectal adenocarcinoma (COAD) is one of the most common gastrointestinal malignancies. There is a pressing need to recognize reliable biomarkers that can improve diagnostic accuracy, predict prognosis, and serve as effective molecular targets. Glutathione peroxidase 4 (GPX4) is an important antioxidant protein. Evidence demonstrates that abnormal expression of GPX4 is related to cancer initiation and progression. However, the role of GPX4 in COAD remains unclear. Methods: We employed bioinformatics analysis and conducted subsequent validation of biological processes, including cell counting kit-8 assay (CCK-8), colony formation assay, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), 5-ethynyl-2′-deoxyuridine assay… More >

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Guo-Zhi Xu^1,2, Han-Yang Guan¹, Yan-Guan Guo¹, Yi-Ran Zhang¹, Jing-Hua Pan¹, Simin Luo³, Hui Ding¹, Yunlong Pan^1,*, Qi Yao^4,*
Oncology Research, Vol.33, No.8, pp. 1947-1967, 2025, DOI:10.32604/or.2025.060440 - 18 July 2025
（This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
Abstract Background: Tumor angiogenesis is related to solid tumor occurrence. Ubiquitin-specific peptidase 13 (USP13) is a deubiquitinating enzyme with a pivotal effect on tumor proliferation, metastasis, and tumorigenesis. Nonetheless, its effect on colorectal cancer (CRC) angiogenesis remains poorly understood. Methods: Human umbilical vein endothelial cells (HUVECs) and CRC cells were cultivated, followed by USP13 knockdown/overexpression using shRNA lentiviral vectors or plasmids. Conditioned media (CM) from treated CRC cells were collected to assess HUVEC migration, invasion, and tube formation. Phosphatase and tensin homolog (PTEN) overexpression and recombinant vascular endothelial growth factor A (VEGFA) rescue experiments were performed.… More >

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903

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Fang Xu^1,2,#, Wan Li^1,#, Xiang-Jin Zheng^1,2, Yue Hao^1,2, Yi-Hui Yang^1,2, Hong Yang^1,2, Sen Zhang^1,2, Wan-Xin Cao^1,2, Xiao-Xue Li^1,2, Xu Zhang^1,2, Guan-Hua Du^1,2, Teng-Fei Ji^1,*, Jin-Hua Wang^1,2,*
Oncology Research, Vol.33, No.8, pp. 1969-1989, 2025, DOI:10.32604/or.2025.062386 - 18 July 2025
（This article belongs to the Special Issue: Recent Advances in Cancer Pharmacology)
Abstract Objectives: Colorectal cancer (CRC) is one of the most common cancers all over the world. The progression of CRC is associated with inflammation and disruptions in intestinal flora. 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) has been noted for its potent anti-inflammatory properties. However, the effect of AKBA on colon cancer caused by inflammation and its mechanism are not unclear. The study is to explore the effect of AKBA on CRC and its mechanism. Materials and Methods: Cell proliferation, (5-ethynyl-2^′-deoxyuridine, EdU)-DNA synthesis assay and colony formation were used to assess the effect of AKBA on the proliferation of CRC cells.… More >

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1012

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Gaofeng Pan^1,2,3, Jiali Li^1,2, Weijie Sun⁴, Jiayu He^1,2, Maoying Fu³, Yufeng Gao^1,2,*
Oncology Research, Vol.33, No.8, pp. 1991-2011, 2025, DOI:10.32604/or.2025.063993 - 18 July 2025
（This article belongs to the Special Issue: Identification of potential targets and biomarkers for cancers and the exploration of novel molecular mechanisms of tumorigenesis and metastasis)
Abstract Aims: The aim of this study is to develop a prognostic model for hepatocellular carcinoma (HCC) using stemness-related genes (SRGs), while also pinpointing and validating pivotal genes associated with this process. Methods: Utilizing the TCGA and ICGC database, a prognostic stemness-related scores (SRS) for HCC through a combination of WGCNA and machine learning. Bioinformatics analysis evaluated tumor immune infiltration characteristics and drug sensitivity in different SRS subgroups, identifying the key gene TOMM40L. qRT-PCR and IHC were employed to detect the expression level of TOMM40 L. Kaplan-Meier survival analysis assessed the prognostic value of TOMM40L in… More >

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900

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Zhun Yu^1,2, Jie Wang^1,2, Guoping Xu^1,2,*
Oncology Research, Vol.33, No.8, pp. 2013-2035, 2025, DOI:10.32604/or.2025.061757 - 18 July 2025
（This article belongs to the Special Issue: Breast Cancer Biomarkers and Drug Targets Discoveries Towards a More Personalized Treatment Setting)
Abstract Objectives: Triple-negative breast cancer (TNBC) presents a major treatment challenge due to its aggressive behavior. The dysfunction of the Golgi apparatus (GA) contributes to the development of various cancers. This study aimed to utilize GA-related genes (GARGs) to forecast the prognosis and immune profile of TNBC. Methods: The data were downloaded from The Cancer Genome Atlas (TCGA) database, including 175 TNBC and 99 healthy samples. The differentially expressed GARGs (DEGARGs) were analyzed using the TCGA biolinks package. The patients with TNBC were classified into two clusters utilizing the ConsensusClusterPlus package according to prognosis-related DEGARGs, followed by… More >

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933

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Li Yu^1,2,3, Xiaoyan Zhang^1,2, Yan Feng^1,4, Xinyue Liao^1,4, Tiejun Zhou⁵, Hang Si^1,4, Yun Feng^1,4, Decai Wang^6,*, Yongxian Lai^1,7,*
Oncology Research, Vol.33, No.8, pp. 2037-2053, 2025, DOI:10.32604/or.2025.064276 - 18 July 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Background: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy with a low five-year survival rate. ATP-binding cassette subfamily B member 5 (ABCB5) has been linked to tumorigenesis. However, its role in inducing OSCC remains unclear. Methods: Quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blot, and immunocytochemistry (ICC) were performed to examine the level of ABCB5 in OSCC (CAL27 and HSC-3) and human oral keratinocyte (HOK). ABCB5 was knocked down in CAL27 cells using ABCB5-specific small interfering RNA (ABCB5 siRNA), and its contribution to migration, invasion, and epithelial-mesenchymal transition (EMT),… More >

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ARTICLE

Fei Ren^1,#, Yansen Cai^2,#, Yang Song^1,*
Oncology Research, Vol.33, No.8, pp. 2055-2074, 2025, DOI:10.32604/or.2025.061301 - 18 July 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Objectives: Epigenetic changes, particularly N6-methyladenosine (m6A) modifications, play a pivotal role in cancer development. This study explored the role of ovarian tumor deubiquitinase 7B (OTUD7B) in esophageal squamous cell carcinoma (ESCC) in the context of m6A methylation and the hypoxia-inducible factor-1α (HIF-1α) pathway. Methods: The GSE179267 dataset was used to conduct differential gene expression analysis to identify key m6A-enriched genes. The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Sequence-based RNA Adenosine Methylation Site Predictor (SRAMP) databases were used to evaluate the expression of OTUD7B in ESCC and its correlation with methyltransferase-like 14… More >

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ARTICLE

MELISSA SáNCHEZ-RODRíGUEZ^1,2, ROBERTO LAZZARINI-LECHUGA³, VERóNICA SOUZA-ARROYO^1,4, LETICIA BUCIO-ORTIZ^1,4, ROXANA U. MIRANDA-LABRA^1,4, MONSERRAT GERARDO-RAMíREZ¹, ARACELI PáEZ-ARENAS⁵, MOISES VERGARA-MENDOZA⁶, MARíA CONCEPCIóN GUTIéRREZ-RUIZ^1,4, ALEJANDRO ESCOBEDO-CALVARIO^1,2,*, LUIS E. GOMEZ-QUIROZ^1,4,*
Oncology Research, Vol.33, No.8, pp. 2075-2084, 2025, DOI:10.32604/or.2025.064899 - 18 July 2025
Abstract Background: Growth differentiation factor 11 (GDF11), a transforming growth factor-beta superfamily member, is a crucial protein involved in many differentiation processes in embryogenesis and morphogenesis, and it has been extensively characterized due to its capacity to target poorly differentiated cells, including transformed or cancer cells. Aim: In the present work, we aimed to describe the effects on migration, proliferation, and metabolism in the T-cell acute lymphoblastic leukemia-derived cell line Jurkat. Methods: Based on previous evidence, we analyzed metabolic changes exerted by GDF11 and its relationship with the aggressive phenotype. Results: We found a profound impact on More >

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781

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Chuncheng Liu¹, Xiaohan Liu¹, Ziqi Li¹, Yanruoxue Wei¹, Bangdong Liu², Peng Zhu², Yukun Liu^1,2,*, Ran Zhao^1,2,*
Oncology Research, Vol.33, No.8, pp. 2085-2105, 2025, DOI:10.32604/or.2025.065739 - 18 July 2025
（This article belongs to the Special Issue: Unraveling cell death in solid tumors: single-cell & spatial transcriptomics illuminate therapeutic target)
Abstract Background: VPS37A (VPS37A subunit of ESCRT-I), a component of the ESCRT-I (endosomal sorting complex required for transport I) complex, mediates vesicular trafficking through sorting endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Although accumulating evidence indicates that VPS37A deficiency occurs in numerous malignancies and exerts tumor-suppressive effects during cancer progression, its functional significance in colorectal cancer (CRC) pathogenesis remains poorly characterized. Therefore, this study aims to further investigate the functional and molecular mechanisms by which VPS37A downregulation contributes to malignant biological phenotypes in CRC, with a specific focus on how its dysregulation affects cell death pathways.… More >

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954

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Junxing Chen^1,#, Luping Pan^1,#, Yunzhi Liu^1,2, Yan Fang¹, Ruoxuan Li¹, Zhiqin Lu^1,3, Anwen Liu^1,4, Yanqing He^5,*, Zhimin Zeng^1,6,*
Oncology Research, Vol.33, No.8, pp. 2107-2121, 2025, DOI:10.32604/or.2025.064237 - 18 July 2025
Abstract Background: Non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) have a very poor prognosis. Intrathecal pemetrexed (IP) has shown moderate efficacy in treating patients with NSCLC-LM. Myelosuppression is the most common adverse effect following IP administration. Despite this trend, the specific risk factors contributing to IP-related myelosuppression remain unclear. Methods: This study conducted a retrospective analysis of lung adenocarcinoma (LUAD) patients with LM who received IP treatment at the Second Affiliated Hospital of Nanchang University from April 2017 to April 2024. Risk factors for myelosuppression were identified through univariate and multivariate logistic regression… More >

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Weiwei Chen¹, Xiaodie Zhou², Huiyu Li¹, Yuchen Yang¹, Lu Lu¹, Chunyan Zhu¹, Rong Fang¹, Xiaoyuan Chu¹, Shuping Zhou^3,*, Qian Sun^1,*
Oncology Research, Vol.33, No.8, pp. 2123-2139, 2025, DOI:10.32604/or.2025.063484 - 18 July 2025
（This article belongs to the Special Issue: Advances in Cancer Pharmacology)
Abstract Background: Primary bone marrow diffuse large B-cell lymphoma (PBM-DLBCL) represents an uncommon yet clinically aggressive hematologic malignancy. Despite its significant clinical impact, this entity lacks standardized diagnostic criteria in current WHO classifications. Methods: We performed a retrospective analysis of 55 PBM-DLBCL cases from our institutional database and published literature (2001–2022) to characterize disease features and identify prognostic factors, with particular focus on assessing how different treatment regimens influence therapeutic efficacy and long-term outcomes. Results: The data suggested a potential link between international prognostic index (IPI) scores and poorer survival, albeit without conclusive statistical evidence (p = More >

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749

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Yuhan Wang, Yimei Meng, Wanqiu Xia, Yusen Liang, Yaru Wang, Peiling Li^*, Lei Fang^*
Oncology Research, Vol.33, No.8, pp. 2141-2159, 2025, DOI:10.32604/or.2025.064367 - 18 July 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Background: Ovarian cancer (OC) is a representative malignancy of the female reproductive system, with a poor prognosis. Long non-coding RNAs (lncRNAs) crucially affect tumor development. This study aimed to identify lncRNAs that potentially participated in OC. Methods: LncRNA expression in cells and tissues was quantified using reverse transcription-quantitative PCR, while fluorescence in situ hybridization determined their cellular localization. Various in vitro assays, together with a mouse xenograft model, were employed to elucidate the function of CYMP antisense RNA 1 (CYMP-AS1) in OC. The molecular mechanisms underlying CYMP-AS1 regulation were investigated through RNA pull-down and immunoprecipitation assays, immunofluorescence… More >

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BHAVYADHARSHINI ARUN^1,#, PRARTHANA GOPINATH^1,2,#, ANUP JHA^1,3, NISHTHA TRIPATHI¹, SYED G DASTAGER^4,*, SYED K HASAN^1,3,*
Oncology Research, Vol.33, No.8, pp. 2161-2174, 2025, DOI:10.32604/or.2025.062951 - 18 July 2025
Abstract Background: Acute Myeloid Leukemia (AML) is a highly aggressive clonal hematological malignancy with limited treatment options. This study aimed to evaluate the therapeutic potential of nigericin, a polyether ionophore derived from Streptomyces DASNCL-29, as a mitochondrial-targeted agent for AML treatment. Methods: Nigericin was isolated from Streptomyces DASNCL-29 and characterized via chromatography and NMR. Its cytotoxicity was tested in MOLM13 (sensitive and venetoclax-resistant) and HL60 (sensitive and cytarabine-resistant) cells using the MTT assay. Mitochondrial dysfunction was assessed by measuring reactive oxygen species (ROS), mitochondrial membrane potential (Δψm), and mitochondrial mass. Apoptosis was evaluated with Annexin V/PI assays… More >

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Oncology Research Editorial Offfce
Oncology Research, Vol.33, No.8, pp. 2175-2175, 2025, DOI:10.32604/or.2025.070131 - 18 July 2025
Abstract This article has no abstract. More >

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591

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394

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Oncology Research Editorial Offfce
Oncology Research, Vol.33, No.8, pp. 2177-2177, 2025, DOI:10.32604/or.2025.070133 - 18 July 2025
Abstract This article has no abstract. More >

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589

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449

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Oncology Research Editorial Offfce
Oncology Research, Vol.33, No.8, pp. 2179-2179, 2025, DOI:10.32604/or.2025.070134 - 18 July 2025
Abstract This article has no abstract. More >

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