Special Issues
Table of Content

Drug Targets in Oncology: Mechanisms, Challenges, and Innovations

Submission Deadline: 30 November 2025 (closed) View: 1623 Submit to Special Issue

Guest Editors

Dr. Ajit Prakash

Email: ajit@ad.unc.edu  

Affiliation: Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Research Interests: Drug Discovery, Biochemistry, Cancer biology, Molecular Biology, GPCR

 

Dr. Mohammad Ashhar Iqbal Khan

Email: ashharkh@email.unc.edu   

Affiliation: Department of Biochemistry & Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

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Research Interests: Protein Biochemistry, Structure Biology, Molecular and Cell Biology, Cell mechanobiology, cell adhesion proteins

 

Dr. Tara Chand Yadav

Email: tcyadav@unc.edu   

Affiliation: Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, 27599, United States.

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Research Interests: Structure-Based Drug Designing, Drug Delivery System, Preclinical model development


Summary

Cancer therapy has made significant advancements by targeting well-established cancer drug targets like some kinases and hormone receptors. In recent times, many new drug targets for cancer have emerged. Since there are several parallel mechanisms for cancer development, it's very much needed to uncover more such mechanisms and identify unidentified drug targets. Revealing novel molecular targets for cancer will pave the path for the development of next-generation therapies.

 

This special issue will explore both well-characterized and emerging drug targets in cancer, delving into their mechanisms of action, strategies for therapeutic targeting, and the latest breakthroughs in drug development. By presenting the current state of knowledge and identifying future directions, the issue aims to guide researchers, clinicians, and drug developers in their efforts to improve cancer treatment outcomes.  


Keywords

Cancer drug discovery, drug target

Published Papers


  • Open Access

    REVIEW

    Polyphenols in Pancreatic Cancer Management: Exploring the Roles and Mechanisms of Resveratrol and Epigallocatechin

    David A de la Garza-Kalife, Verónica L Loaiza-Gutiérrez, Esther Alhelí Hernández-Tobías, Carlos A González-Villarreal, Jose Francisco Islas, Michelle G Santoyo-Suárez, Elsa N Garza-Treviño, Paulina Delgado-Gonzalez
    Oncology Research, Vol.33, No.9, pp. 2243-2262, 2025, DOI:10.32604/or.2025.065222
    (This article belongs to the Special Issue: Drug Targets in Oncology: Mechanisms, Challenges, and Innovations)
    Abstract Emerging evidence highlights the potential of bioactive compounds, particularly polyphenols, as adjunctive therapeutic agents in the treatment of pancreatic cancer (PC), one of the most aggressive malignancies. This review focuses on epigallocatechin gallate (EGCG) and resveratrol due to their extensively documented anticancer activity, favorable safety profiles, and their unique ability to modulate multiple signaling pathways relevant to pancreatic tumorigenesis. Among polyphenols, these two have shown superior anti-cancer activity, epigenetic regulatory effects, and synergy with standard chemotherapies in preclinical pancreatic cancer models. Resveratrol exhibits anti-proliferative effects by modulating key signaling pathways, including phosphatidylinositol 3 kinase (PI3K)/protein… More >

    Graphic Abstract

    Polyphenols in Pancreatic Cancer Management: Exploring the Roles and Mechanisms of Resveratrol and Epigallocatechin

  • Open Access

    REVIEW

    The impact of oxidative stress and the NRF2-KEAP1-ARE signaling pathway on anticancer drug resistance

    FLáVIA ALVES VERZA, GUILHERME CARVALHO DA SILVA, FELIPE GARCIA NISHIMURA
    Oncology Research, Vol.33, No.8, pp. 1819-1834, 2025, DOI:10.32604/or.2025.065755
    (This article belongs to the Special Issue: Drug Targets in Oncology: Mechanisms, Challenges, and Innovations)
    Abstract Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, More >

    Graphic Abstract

    The impact of oxidative stress and the NRF2-KEAP1-ARE signaling pathway on anticancer drug resistance

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