Home / Journals / OR / Vol.28, No.3, 2020
  • Open Access

    ARTICLE

    PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways

    Yangmei Zhang*1, Xichang Zhou†1, Long Cheng, Xiang Wang*, Qinglin Zhang, Youwei Zhang*, Sanyuan Sun*
    Oncology Research, Vol.28, No.3, pp. 213-223, 2020, DOI:10.3727/096504019X15668125347026
    Abstract PRKAA1 (protein kinase AMP-activated catalytic subunit 1) is a catalytic subunit of AMP-activated protein kinase (AMPK), which plays a key role in regulating cellular energy metabolism through phosphorylation, and genetic variations in the PRKAA1 have been found to be associated with gastric cancer risk. However, the effect and underlying molecular mechanism of PRKAA1 on gastric cancer tumorigenesis, especially the proliferation and apoptosis, are not fully understood. Our data showed that PRKAA1 is highly expressed in BGC- 823 and MKN45 cells and is expressed low in SGC-7901 and MGC-803 cells in comparison with the other gastric cancer cells. PRKAA1 downregulation by… More >

  • Open Access

    ARTICLE

    MicroRNA-6884-5p Regulates the Proliferation, Invasion, and EMT of Gastric Cancer Cells by Directly Targeting S100A16

    Huifang Lv, Honglin Hou, Huijun Lei, Caiyun Nie, Beibei Chen, Liangyu Bie, Lili Han, Xiaobing Chen
    Oncology Research, Vol.28, No.3, pp. 225-236, 2020, DOI:10.3727/096504019X15753718797664
    Abstract S100 binding protein A16 (S100A16) expression levels are closely associated with microRNA (miRNA) processing. Higher levels of S100A16 are reported during the progression of many cancers. Our study mainly explored the interaction between S100A16 and miR-6884-5p in gastric cancer (GC). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the level of S100A16 and miR-6884-5p in GC tissues and cell lines. The si-S100A16, pcDNA-S100A16, miR-6884-5p mimic or inhibitor was transfected into GC cells, and the effects of S100A16 and miR-6884-5p on the proliferation, invasion, and epithelial–mesenchymal transition (EMT) were explored by qRT-PCR and Western blot assays. Luciferase assays were… More >

  • Open Access

    ARTICLE

    Vinorelbine in Non-Small Cell Lung Cancer: Real-World Data From a Single-Institution Experience

    Stefania Nobili*, Daniele Lavacchi, Gabriele Perrone*, Giulio Vicini, Renato Tassi‡1, Ida Landini*, AnnaMaria Grosso§, Giandomenico Roviello, Roberto Mazzanti, Carmine Santomaggio¶2, Enrico Mini
    Oncology Research, Vol.28, No.3, pp. 237-248, 2020, DOI:10.3727/096504019X15755437099308
    Abstract The use of vinorelbine as a single agent or in combination regimens in non-small cell lung cancer (NSCLC) is associated with satisfactory clinical activity. However, the role of vinorelbine-based chemotherapy in chemonaive locally advanced unresectable or metastatic NSCLC patients, according to real-world treatment patterns, has still not been widely explored. Eighty-one patients treated at a single institution were retrospectively analyzed. Thirty-seven received standard first-line single-agent vinorelbine, and 44 received vinorelbine plus platinum drugs, based on physician’s choice; 61.7% were older than 70 years, and 60.5% were affected by 2 comorbidities. Sixty-three patients were evaluable for objective response: 22% achieved partial… More >

  • Open Access

    ARTICLE

    The Comprehensive Analysis of Efficacy and Safety of CalliSpheres® Drug-Eluting Beads Transarterial Chemoembolization in 367 Liver Cancer Patients: A Multiple-Center, Cohort Study

    Zhiyi Peng*1, Guohong Cao†1, Qinming Hou, Ling Li§, Shihong Ying*, Junhui Sun, Guanhui Zhou, Jian Zhou#, Xin Zhang*, Wenbin Ji**, Zhihai Yu††, Tiefeng Li‡‡, Dedong Zhu§, Wenhao Hu§§, Jiansong Ji¶¶, Haijun Du##, Changsheng Shi***, Xiaohua Guo†††, Jian Fang‡‡‡, Jun Han§§§, Wenjiang Gu¶¶¶, Xiaoxi Xie###, Zhichao Sun****, Huanhai Xu††††, Xia Wu‡‡‡‡, Tingyang Hu§§§§, Jing Huang¶¶¶¶, Hongjie Hu‡‡‡‡, Jiaping Zheng####, Jun Luo####, Yutang Chen####, Wenqiang Yu§§§§, Guoliang Shao####
    Oncology Research, Vol.28, No.3, pp. 249-271, 2020, DOI:10.3727/096504019X15766663541105
    Abstract This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of… More >

  • Open Access

    ARTICLE

    Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance

    Ping Yin*, Wei Wang*, Jian Gao, Yu Bai*, Zhuo Wang*, Lei Na*, Yu Sun*, Chenghai Zhao*
    Oncology Research, Vol.28, No.3, pp. 273-284, 2020, DOI:10.3727/096504020X15783052025051
    Abstract Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced human breast cancer (BC) cell stemness via noncanonical Wnt pathways. Fzd2 was overexpressed in human BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. Fzd2 knockdown (KD) disturbed the mesenchymallike phenotype, migration, and invasion of BC cells. Moreover, Fzd2 KD impaired BC cell mammosphere formation, reduced Lgr5+ BC cell subpopulation, and enhanced sensitivity of BC cells to chemical agents. Mechanistically, Fzd2 modulated and bound with Wnt5a/b and Wnt3 to activate… More >

  • Open Access

    ARTICLE

    Correlating Transcriptional Networks to Papillary Renal Cell Carcinoma Survival: A Large-Scale Coexpression Analysis and Clinical Validation

    Xingliang Feng*1, Meng Zhang*†1, Jialin Meng*, Yongqiang Wang, Yi Liu*, Chaozhao Liang*, Song Fan*
    Oncology Research, Vol.28, No.3, pp. 285-297, 2020, DOI:10.3727/096504020X15791676105394
    Abstract We aimed to investigate the potential mechanisms of progression and identify novel prognosis-related biomarkers for papillary renal cell carcinoma (PRCC) patients. The related data were derived from The Cancer Genome Atlas (TCGA) and then analyzed by weighted gene coexpression network analysis (WGCNA). The correlation between each module and the clinical traits were analyzed by Pearson’s correlation analysis. Pathway analysis was conducted to reveal potential mechanisms. Hub genes within each module were screened by intramodule analysis, and visualized by Cytoscape software. Furthermore, important hub genes were validated in an external dataset and clinical samples. A total of 5,839 differentially expressed genes… More >

  • Open Access

    ARTICLE

    MafF Is Regulated via the circ-ITCH/miR-224-5p Axis and Acts as a Tumor Suppressor in Hepatocellular Carcinoma

    Minhua Wu*1, Xubin Deng†1, Yu Zhong‡1, Li Hu*, Xiujuan Zhang§, Yanqin Liang*, Xiaofang Li, Xiaoxia Ye*
    Oncology Research, Vol.28, No.3, pp. 299-309, 2020, DOI:10.3727/096504020X15796890809840
    Abstract MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. But the expression and function of MafF in hepatocellular carcinoma (HCC) remain unclear. In this study, we investigated the relationship between endogenous MafF expression and HCC progression and explored the regulatory mechanism of MafF expression in HCC. We found that MafF decreased in HCC tissues and cells. Lentivirus-mediated MafF overexpression inhibited HCC cell proliferation and induced cell apoptosis. Bioinformatics analysis and luciferase assay identified MafF as a direct target of miR-224-5p. RNA pull-down assay demonstrated that circular RNA circ-ITCH… More >

  • Open Access

    ARTICLE

    lncRNA HOXA11-AS Promotes Proliferation and Migration via Sponging miR-155 in Hypopharyngeal Squamous Cell Carcinoma

    Jianing Xu*†, Qiyu Bo, Xiang Zhang§, Dapeng Lei, Jue Wang*, Xinliang Pan
    Oncology Research, Vol.28, No.3, pp. 311-319, 2020, DOI:10.3727/096504020X15801233454611
    Abstract Hypopharyngeal squamous cell carcinoma (HSCC) remains one of the most lethal malignancies in the head and neck. Long noncoding RNA (lncRNA) HOXA11-AS is proven to function as an oncogene and a therapeutic target in various tumors. Our previous study and others have demonstrated that HOXA11-AS is one of the most upregulated lncRNAs in HSCC. However, the role of HOXA11-AS in HSCC has not yet been identified. The current study demonstrated that the expression of HOXA11-AS was significantly upregulated in HSCC tumors and was positively associated with lymph node metastasis. Moreover, functional experiments revealed that HOXA11-AS knockdown suppressed the proliferation and… More >

  • Open Access

    ARTICLE

    miRNA–mRNA Profiling Reveals Prognostic Impact of SMC1A Expression in Acute Myeloid Leukemia

    Nikhil Gadewal*1, Rohit Kumar†1, Swapnil Aher, Anagha Gardane, Tarang Gaur, Ashok K. Varma*‡§, Navin Khattry, Syed K. Hasan†§¶
    Oncology Research, Vol.28, No.3, pp. 321-330, 2020, DOI:10.3727/096504020X15816752427321
    Abstract Acute myeloid leukemia (AML) with NPM1 mutation is a disease driving genetic alteration with good prognosis. Although it has been suggested that NPM1 mutation induces chemosensitivity in leukemic cells, the underlying cause for the better survival of NPM1 mutated patients is still not clear. Mutant NPM1 AML has a unique microRNA and their target gene (mRNA) signature compared to wild-type NPM1. Dynamic regulation of miRNA–mRNA has been reported to influence the prognostic outcome. In the present study, in silico expression data of miRNA and mRNA in AML patients was retrieved from genome data commons, and differentially expressed miRNA and mRNA… More >

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