Open Access
ARTICLE
Li Zhu*, Lijun Xue†
Oncology Research, Vol.27, No.6, pp. 629-634, 2019, DOI:10.3727/096504018X15228018559434
Abstract Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless,
little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast
cancer (BC), and thus we investigated how kaempferol suppresses the growth of BC cells. The cells were
treated with kaempferol, and the effects on multiple cancer-associated pathways were evaluated. The MTS
assay was used to study the cell growth inhibition induced by kaempferol. The cell cycle was analyzed by
flow cytometry. Western blotting was used to analyze cellular apoptosis and DNA damage. We found that the… More >
Open Access
ARTICLE
Jing Tang*1, Xu Yong Li†1, Jing Bo Liang‡, De Wu§, Li Peng¶, Xiaobing Li¶
Oncology Research, Vol.27, No.6, pp. 635-641, 2019, DOI:10.3727/096504018X15288447760357
Abstract Apatinib is an oral TKI with antiangiogenic properties, and it is currently approved for the treatment of advanced
gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell
lung cancer (NSCLC). Since the combination of chemotherapy and an antiangiogenic agent has been shown
to be a feasible strategy in NSCLC, it is conceivable that a similar approach combining apatinib with chemotherapy may yield clinical activity. With this in mind, we investigated the efficiency of apatinib in combination
with pemetrexed or docetaxel in advanced NSCLC. We treated a total of 20 patients with… More >
Open Access
ARTICLE
Qiang Li*†1, Qi Liu*1, Wanpeng Cheng*, Huiyan Wei*, Wenqian Jiang*, Fang E*, Yuan Yu*, Jianfeng Jin*, Chaoxia Zou*‡
Oncology Research, Vol.27, No.6, pp. 643-651, 2019, DOI:10.3727/096504018X15415906335771
Abstract Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast
cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of
HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed
that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated
indices for epithelial–mesenchymal transition (EMT), migration, and proliferation of 4T1 cells were evaluated.
The results show that HO-1 inhibits EMT, migration, and proliferation of 4T1 cells. In addition, the Notch1/
Slug pathway is… More >
Open Access
ARTICLE
Zhongyi Mu*†1, Dan Dong*1, Ning Wei‡§, Mingli Sun¶, Wei Wang*, Yue Shao*, Jian Gao*, Ping Yin*, Chenghai Zhao*
Oncology Research, Vol.27, No.6, pp. 653-661, 2019, DOI:10.3727/096504018X15420748671075
Abstract The lncRNA AFAP1-AS1, oriented from an antisense direction to the protein-coding gene AFAP1 in the opposite strand, was upregulated in a variety of tumors and associated with poor prognosis, including lung cancer,
breast cancer, ovarian cancer, and so on. However, the biological role of AFAP1-AS1 in clear cell renal cell
carcinoma (ccRCC) is still unknown. We observed that AFAP1-AS1 expression was significantly upregulated
in ccRCC tissues and that patients with high-level expression of AFAP1-AS1 had a shorter overall survival.
Knockdown of AFAP1-AS1 markedly suppressed the progression of proliferation, invasion, migration, and
EMT in ccRCC cells. Downregulation of AFAP1-AS1 resulted in… More >
Open Access
ARTICLE
Zhen Li*1,
Xin Li*1,
Xiao Du†, Henghui Zhang†, Zhengyang Wu*, Kewei Ren*, Xinwei Han*
Oncology Research, Vol.27, No.6, pp. 663-672, 2019, DOI:10.3727/096504018X15420741307616
Abstract Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long noncoding
RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression
of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. In
this study, the SNHG1 levels were boosted in CCA cell lines, and knockdown of SNHG1 repressed CCA cell
proliferation and invasion in vitro. The data also demonstrated that miR-140 could act as a target of SNHG1 in
CCA and inhibited CCA cell proliferation and invasion, whereas the inhibition effects were relieved by overexpression of… More >
Open Access
ARTICLE
Hong Li*1,
Yaning Tian*1,
Xiang Li*, Bin Wang†, Dongzhi Zhai*, Yingying Bai*,
Changhu Dong*, Xu Chao*‡
Oncology Research, Vol.27, No.6, pp. 673-680, 2019, DOI:10.3727/096504018X15426261956343
Abstract IARS2 encodes mitochondrial isoleucine-tRNA synthetase, which mutation may cause multiple diseases.
However, the biological function of IARS2 on acute myeloid leukemia (AML) has not yet been identified.
In the present study, qRT-PCR was used to determine the expression of IARS2 in K562, THP1, and HL-60
leukemia cells. Additionally the mRNA levels of IARS2 in CD34 cells and AML cells obtained from patients
were detected by qRT-PCR. IARS2-shRNA lentiviral vector was established and used to infect acute myeloid
leukemia HL-60 cells. qRT-PCR and Western blot analysis were employed to assess the knockdown effect of
IARS2. The proliferation rate and cell cycle… More >
Open Access
ARTICLE
Yanjie Han*1,
Xinxin Li*1,
Fei He†1,
Jiliang Yan*, Chunyan Ma*, Xiaoli Zheng‡, Jinli Zhang*,
Donghui Zhang*, Cuiping Meng*, Zhen Zhang*, Xinying Ji§
Oncology Research, Vol.27, No.6, pp. 681-690, 2019, DOI:10.3727/096504018X15424939990246
Abstract Plasmacytoma variability translocation 1 (PVT1), an oncogene, has been reported to be highly expressed in
many tumors, including human glioma, gastric cancer, and non-small cell lung cancer. Functionally, it could
also regulate the development of tumor cells. However, its specific roles and pathogenesis in human gliomas
are still not clear. This study investigated the function and mechanism of PVT1 knockdown in the proliferation
and malignant transformation of human gliomas. We first examined the expression levels of PVT1 and miR-
424 in human glioma tissues and cell lines. We also used gene manipulation techniques to explore the effects of
PVT1 knockdown… More >
Open Access
ARTICLE
Fang Chen*, Dongqiang Yang†, Yuhua Ru‡, Shan Cao*, Aishe Gao*
Oncology Research, Vol.27, No.6, pp. 691-701, 2019, DOI:10.3727/096504018X15426763753594
Abstract Escalating evidence suggests that microRNA-101 (miR-101) is implicated in the development and progression of various cancers, including papillary thyroid carcinoma (PTC). However, the biological function and
molecular mechanisms of miR-101 in PTC are still unclear. In this study, we demonstrated that miR-101
expression was significantly decreased in PTC tissues and cell lines. Clinically, a low level of miR-101 was
positively associated with advanced histological stages and lymph node and distant metastases. The expression
of CXCL12 was negatively correlated with miR-101 level in PTC. CXCL12 was validated as a direct target
of miR-101 in PTC cells. Functional experiments proved that miR-101… More >
Open Access
ARTICLE
Wei Ni*†‡, Lin Luo*†‡, Ping Zuo*†‡, Renping Li*†‡, Xiaobing Xu*†‡, Fan Wen*†‡, Dong Hu*†‡
Oncology Research, Vol.27, No.6, pp. 703-712, 2019, DOI:10.3727/096504018X15426775024905
Abstract Glioma is a commonly diagnosed brain tumor that shows high mortality rate. Despite the great advancement of
cancer therapy in recent years, chemotherapy is still an important approach for treatment of glioma. However,
long-term chemotherapy usually causes serious side effects or complications. It is desirable to take strategies
to enhance the efficacy of current chemotherapy. In the present study, we observed obvious upregulation of
miR-374a in glioma cells. More importantly, we found that knockdown of miR-374a was able to enhance the
etoposide-induced cytotoxicity against glioma cells. Mechanically, we demonstrated that FOXO1 was the target of miR-374a in glioma. Treatment with… More >
Open Access
ARTICLE
Hitoshi Takamatsu*1,
Ken-ichi Yamamoto*1,
Nahoko Tomonobu*, Hitoshi Murata*, Yusuke Inoue†,
Akira Yamauchi‡, I Wayan Sumardika*§, Youyi Chen*, Rie Kinoshita*, Masahiro Yamamura¶,
Hideyo Fujiwara#, Yosuke Mitsui*,
**, Kota Araki*††, Junichiro Futami‡‡, Ken Saito§§, Hidekazu Iioka§§,
I Made Winarsa Ruma§, Endy Widya Putranto¶¶, Masahiro Nishibori##, Eisaku Kondo§§,
Yasuhiko Yamamoto***, Shinichi Toyooka††, Masakiyo Sakaguchi*
Oncology Research, Vol.27, No.6, pp. 713-727, 2019, DOI:10.3727/096504018X15433161908259
Abstract The fertile stroma in pancreatic ductal adenocarcinomas (PDACs) has been suspected to greatly contribute
to PDAC progression. Since the main cell constituents of the stroma are fibroblasts, there is crosstalking(s)
between PDAC cells and surrounding fibroblasts in the stroma, which induces a fibroblast proliferation burst.
We have reported that several malignant cancer cells including PDAC cells secrete a pronounced level of
S100A11, which in turn stimulates proliferation of cancer cells via the receptor for advanced glycation end
products (RAGE) in an autocrine manner. Owing to the RAGE+
expression in fibroblasts, the extracellular
abundant S100A11 will affect adjacent fibroblasts. In this… More >
Open Access
ARTICLE
Yulong Jin*, Li Xu*, Xiaodong Wu†, Juan Feng*, Mimi Shu*, Hongtao Gu*, Guangxun Gao*,
Jinyi Zhang‡, Baoxia Dong*, Xiequn Chen*
Oncology Research, Vol.27, No.6, pp. 729-737, 2019, DOI:10.3727/096504018X15443011011637
Abstract Multiple myeloma (MM) is a hematopoietic malignancy characterized by the clonal proliferation of antibodysecreting plasma cells. Bortezomib (BZM), the first FDA-approved proteasome inhibitor, has significant
antimyeloma activity and prolongs the median survival of MM patients. However, MM remains incurable
predominantly due to acquired drug resistance and disease relapse. -Catenin, a key effector protein in
the canonical Wnt signaling pathway, has been implicated in regulating myeloma cell sensitivity to BZM.
Decitabine (DAC) is an epigenetic modulating agent that induces tumor suppressor gene reexpression based
on its gene-specific DNA hypomethylation. DAC has been implicated in modulating Wnt/ -catenin signaling
by promoting the… More >
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