Open Access

REVIEW

Rosa Scarpitta^1,#, Emiliano Cappello^1,#, Alice Cangialosi¹, Veronica Gori¹, Giulia De Luca^1,2, Giovanni Gori³, Guido Bocci^1,*
Oncology Research, Vol.33, No.10, pp. 2603-2656, 2025, DOI:10.32604/or.2025.066260 - 26 September 2025
（This article belongs to the Special Issue: Cutting-edge strategies for pediatric solid tumors: diagnostic and therapeutic insights)
Abstract Central nervous system (CNS) tumors are the most common solid tumors in pediatric patients and the leading cause of childhood cancer-related mortality. Their rarity compared to adult cancers has made enrolling sufficient cases for clinical trials challenging. Consequently, pediatric CNS tumors were long treated with adult protocols despite distinct biological and clinical characteristics. This review examines key aspects of phase I pediatric oncology trials, including study design, primary outcomes, and pharmacological approaches, along with secondary considerations like clinical responses and ethical aspects. Firstly, we evaluated all phase I trial protocols focusing on pediatric CNS tumors… More >

Graphic Abstract

View

1764

Download

351

Open Access

REVIEW

Eleni Kokkotou^*, Andriani Charpidou, Nikolaos Syrigos
Oncology Research, Vol.33, No.10, pp. 2657-2672, 2025, DOI:10.32604/or.2025.066228 - 26 September 2025
（This article belongs to the Special Issue: Shaping the Future: The Next Evolution of Cancer Immunotherapy)
Abstract Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) serve an essential role in tumor angiogenesis and have emerged as potential therapeutic targets in lung cancer. This review explores the significance of serum VEGF levels as a predictive biomarker in non-small cell lung cancer (NSCLC). The VEGF family, consisting of VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor (PlGF), engages with specific receptors, including tyrosine kinase receptors (VEGFR-1, VEGFR-2, and VEGFR-3) and neuropilin receptors (NRP-1 and NRP-2), to promote angiogenesis and lymphangiogenesis. VEGF-A, the primary component of the VEGF family, binds to VEGFR-2 to stimulate… More >

View

1739

Download

264

Open Access

REVIEW

Yuhan Xie¹, Shaden A. M. Khalifa², Hesham R. El-Seedi³, Paolo Coghi^1,4,*
Oncology Research, Vol.33, No.10, pp. 2673-2697, 2025, DOI:10.32604/or.2025.067666 - 26 September 2025
Abstract Podophyllotoxin is a well-studied natural product. Because of its unique structure and ability to inhibit cancer cells, it has been changed in different ways to find out its pharmacological properties. This paper discusses the common chemical modifications of podophyllotoxin molecules, including the C-4 and E-4 site replacements. Furthermore, its common inhibitory effects on cancer cells and antiparasitic activities, among others, are outlined by the connection between conformational changes and pharmacological activities. Importantly, Podophyllotoxin can effectively overcome the phenomenon of multidrug resistance through a dual-targeting mechanism, including inhibition of microtubule protein synthesis and topoisomerase II activity, More >

Graphic Abstract

View

2211

Download

1165

Open Access

REVIEW

Minseo Hong, Jea-Hyun Baek^*
Oncology Research, Vol.33, No.10, pp. 2699-2724, 2025, DOI:10.32604/or.2025.067487 - 26 September 2025
Abstract AMP-activated protein kinase (AMPK) is a highly conserved serine/threonine kinase that functions as a central regulator of cellular energy status. In cancer, where metabolic reprogramming enables rapid proliferation and survival under stress, AMPK functions as a metabolic checkpoint that restrains tumor growth by inhibiting biosynthetic pathways and promoting catabolic processes, such as autophagy and fatty acid oxidation. Given its role in opposing many hallmarks of cancer metabolism, AMPK has attracted significant interest as a therapeutic target. This review examines the molecular mechanisms by which AMPK influences tumor progression and evaluates the preclinical and clinical evidence… More >

View

2440

Download

1212

Open Access

REVIEW

Lina Corgiolu, Giuseppe Giannaccare^*, Alberto Cuccu
Oncology Research, Vol.33, No.10, pp. 2725-2740, 2025, DOI:10.32604/or.2025.067221 - 26 September 2025
Abstract Topical chemotherapy is increasingly used to treat ocular surface tumors as a primary therapy and an adjuvant treatment after surgical excision. The most employed topical agents include mitomycin C (MMC), 5-fluorouracil (5-FU), and interferon alpha-2b (IFNα2b), each with distinct mechanisms of action, efficacy profiles, and toxicity risks. Although these agents offer effective tumor control and allow for a non-invasive approach in many cases, ocular surface complications requiring medical or surgical management can occur. This summarizes the adverse effect and outilines practical strategies for their prevention and treatment. MMC is the most potent agent but also… More >

View

2132

Download

1165

Open Access

REVIEW

Sofija Jovanović Stojanov¹, Marija Grozdanić¹, Mila Ljujić², Sandra Dragičević², Miodrag Dragoj¹, Jelena Dinić^1,*
Oncology Research, Vol.33, No.10, pp. 2741-2785, 2025, DOI:10.32604/or.2025.067126 - 26 September 2025
Abstract Anticancer drug resistance remains a major challenge in cancer treatment hindering the efficacy of chemotherapy and targeted therapies. Conventional two-dimensional (2D) cell cultures cannot replicate the complexity of the in vivo tumor microenvironment (TME), limiting their utility for drug resistance research. Therefore, three-dimensional (3D) tumor models have proven to be a promising alternative for investigating chemoresistance mechanisms. In this review, various cancer 3D models, including spheroids, organoids, scaffold-based models, and bioprinted models, are comprehensively evaluated with a focus on their application in drug resistance studies. We discuss the materials, properties, and advantages of each model, highlighting More >

Graphic Abstract

View

2202

Download

1203

Open Access

REVIEW

Neha Raina¹, Radha Rani², Mahika Kanojia², Avril Mathias³, Keshav Raj Paudel^4,*, Ashish Garg⁵, Hardeep Singh Tuli⁶, A. T. M. Mijanur Rahman⁷, Vetriselvan Subramaniyan⁸, Madhu Gupta^2,*
Oncology Research, Vol.33, No.10, pp. 2787-2831, 2025, DOI:10.32604/or.2025.066624 - 26 September 2025
（This article belongs to the Special Issue: Breast Cancer Biomarkers and Drug Targets Discoveries Towards a More Personalized Treatment Setting)
Abstract Breast cancer is among the most prevalent cancers in females globally and has the highest mortality rate. The emergence of pharmacologic resistance in breast cancer is a significant challenge for researchers in the pursuit of effective treatment. Investigations in cancer nanotechnology have been transformed by the advancement of smart polymers, lipids, and inorganic materials. Research is now being conducted in the field of innovative nano-pharmaceutical formulations aimed at enhancing the efficacy and durability of chemotherapy. Nanotechnology-based delivery systems are beneficial for combating breast cancer due to theranostic applications, augmented drug encapsulation, decreased degradation, and minimal… More >

View

2877

Download

336

Open Access

REVIEW

Lang Chen¹, Rui Dong¹, Xuan Huan^2,*
Oncology Research, Vol.33, No.10, pp. 2833-2856, 2025, DOI:10.32604/or.2025.063644 - 26 September 2025
（This article belongs to the Special Issue: Identification of potential targets and biomarkers for cancers and the exploration of novel molecular mechanisms of tumorigenesis and metastasis)
Abstract Deubiquitinating enzymes (DUBs) are key enzymes capable of cleaving ubiquitin chains and synergizing with ubiquitination modifications to regulate the function of key proteins and maintain normal physiological functions. OTUDs are a key subfamily of the ovarian tumor protease (OTU) family, with important DUB activities, and include mainly OTUD1, OTUD2, OTUD3, OTUD4, OTUD5, OTUD6A, and OTUD6B. In recent years, research on OTUD proteins has been gradually emphasized, and their aberrant expression has demonstrated significant research value in many diseases, such as cancer, immune abnormalities, neurological disorders, and embryonic developmental abnormalities. Therefore, a comprehensive understanding of the… More >

View

840

Download

243

Open Access

REVIEW

Xinyao Huang^1,#, Renjun Gu^2,3,#, Ziyun Li^4,*, Fangyu Wang^3,*
Oncology Research, Vol.33, No.10, pp. 2857-2902, 2025, DOI:10.32604/or.2025.066805 - 26 September 2025
（This article belongs to the Special Issue: Multi-Omics Approaches for Precision Medicine)
Abstract Cold tumors, defined by insufficient immune cell infiltration and a highly immunosuppressive tumor microenvironment (TME), exhibit limited responsiveness to conventional immunotherapies. This review systematically summarizes the mechanisms of immune evasion and the therapeutic strategies for cold tumors as revealed by multi-omics technologies. By integrating genomic, transcriptomic, proteomic, metabolomic, and spatial multi-omics data, the review elucidates key immune evasion mechanisms, including activation of the WNT/β-catenin pathway, transforming growth factor-β (TGF-β)–mediated immunosuppression, metabolic reprogramming (e.g., lactate accumulation), and aberrant expression of immune checkpoint molecules. Furthermore, this review proposes multi-dimensional therapeutic strategies, such as targeting immunosuppressive pathways (e.g.,… More >

Graphic Abstract

View

2743

Download

443

Open Access

ARTICLE

Xiao-Xiao Luo, Bi Peng, Jian-Hua Wang, Guang-Yuan Hu, Xiang-Lin Yuan, Guo-Xian Long^*
Oncology Research, Vol.33, No.10, pp. 2903-2921, 2025, DOI:10.32604/or.2025.066308 - 26 September 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Objective: The World Health Organization (WHO) grading based on histopathology cannot always accurately predict tumor behavior of meningiomas. To overcome the limitations of the WHO grading, the study aims to propose a novel oxidative stress-based molecular classification for WHO grade 2/3 meningiomas. Methods: Differentially expressed oxidative stress-related genes were analyzed between 86 WHO grade 1 (low grade) meningiomas and 99 grade 2/3 (high grade) meningiomas. An oxidative stress-based molecular classification was developed in high-grade meningiomas through consensus clustering analysis. Immune microenvironment features, responses to immunotherapy and chemotherapy, and targeted drugs were evaluated. Three machine learning… More >

View

1451

Download

241

Open Access

ARTICLE

Norbert Nass^1,2,#, Mohamad-Kamal Yaakoub^1,#, Alexandra-Victorita Simion³, Hartmut Kroll⁴, Sabine Westphal³, Judith Pannier¹, Gerhard Behre^1,*
Oncology Research, Vol.33, No.10, pp. 2923-2935, 2025, DOI:10.32604/or.2025.067561 - 26 September 2025
Abstract Background: Patients with hemato-oncological malignancies may respond insufficiently to vaccination, especially in terms of antibody titer. The antibody response depends on the type of malignancy as well as the type and timing of treatment. We intended to evaluate this using real-world data from patients of our regional hospital. This study also considers the role of immune status, including T-cell activation markers, in predicting vaccination success. Methods: Seventeen patients of our hospital having a hematological malignancy were included in this study, including myeloma, lymphoma, as well as acute myeloid leukemia (AML) and chronic lymphoid leukemia (CLL).… More >

View

2248

Download

1157

Open Access

ARTICLE

Yi Jin¹, Zexing Shan², Fan Yang¹, Xinwen Fan¹, Jie Lin³, Zeqing Huang^1,*, Xudong Zhu^3,4,*
Oncology Research, Vol.33, No.10, pp. 2937-2960, 2025, DOI:10.32604/or.2025.062250 - 26 September 2025
（This article belongs to the Special Issue: Unraveling cell death in solid tumors: single-cell & spatial transcriptomics illuminate therapeutic target)
Abstract Background: As a major histopathological subtype of gastric cancer (GC), stomach adenocarcinoma (STAD) is an important malignant tumor in the digestive system. Increasing evidence also indicates that endoplasmic reticulum (ER) stress plays a pivotal role in the pathogenesis and progression of GC. Therefore, this study aims to screen and identify vital ER stress-related genes that could contribute to the malignant development and poor prognosis for STAD. Methods: A novel ER stress-related risk score signature was developed employing machine learning techniques. Then, a prognostic prediction nomogram was also built based on the clinicopathological characteristics and the… More >

Graphic Abstract

View

807

Download

232

Open Access

ARTICLE

Shiyang Zhang^1,#, Jingchen Li^1,#, Qianxu Jin², Siyu Zhu¹, Hongshan Yan², Yizheng Wang³, Zihan Song¹, Liqiang Liu^1,*
Oncology Research, Vol.33, No.10, pp. 2961-2979, 2025, DOI:10.32604/or.2025.064300 - 26 September 2025
（This article belongs to the Special Issue: Signaling Pathway Crosstalk in Malignant Tumors: Molecular Targets and Combinatorial Therapeutics)
Abstract Background: Glioma is the most common tumor of the central nervous system with a poor prognosis. This study aims to explore the role of calcium/calmodulin-dependent protein kinase IIβ (CAMK2B) in regulating the malignant progression of glioma cells, as well as the molecular mechanisms underlying these malignant behaviors. Methods: The correlation between CAMK2B expression in gliomas and patient prognosis was analyzed using immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and western blot. Furthermore, the study explored the role of CAMK2B in glioma cell proliferation, invasion, and migration using cell counting kit-8 (CCK-8), 5-Ethynyl-2^′-deoxyuridine (EdU), wound healing,… More >

View

993

Download

264

Open Access

ARTICLE

Ting Wei^1,2,#, Pengli Wei^2,3,#, Yalei Wang^1,2, Yaqiu Mao^2,3, Jian Yan², Xiaotong Hu², Zhenze Qi², Xu Cai², Changkai Jia², Zhiyuan Zhao², Bingkun Li², Min Qiao², Yaxin Zou^2,3, Tingting Yang⁴, Shiyang Sun², Xuesong Feng³, Pengyun Li^2,*, Hongzhou Shang^1,*, Zhibing Zheng²
Oncology Research, Vol.33, No.10, pp. 2981-3006, 2025, DOI:10.32604/or.2025.065123 - 26 September 2025
（This article belongs to the Special Issue: New Insights in Drug Resistance of Cancer Therapy: A New Wine in an Old Bottle)
Abstract Objectives: Immunomodulatory drugs (IMiDs), functioning as molecular glue degraders, have been approved for treating various hematological malignancies; however, the inevitable acquired drug resistance resulting from their skeletal similarity and hematological toxicities poses significant obstacles to their clinical treatment. The study aimed to develop degraders with potent efficiency and low toxicity. Methods: Phenotypic profiling, elaborate structure-activity relationships (SAR), rational drug design and degradation profiles investigations, quantitative proteomics analysis and cell-based functional studies, and pharmacokinetic studies were conducted to develop more potent degraders. Results: This study developed novel CRBN-binding moieties through methylene deletion in lenalidomide’s isoindole core. Lead… More >

Graphic Abstract

View

1656

Download

630

Open Access

ARTICLE

Liang Yu^1,#, Mingrui Zhao^1,#, Jinhui Liu², Yuqin Yang¹, Lin Zhang², Wenjun Cheng^2,*
Oncology Research, Vol.33, No.10, pp. 3007-3022, 2025, DOI:10.32604/or.2025.065137 - 26 September 2025
Abstract Background: The benefit of adjuvant chemotherapy for stage I ovarian endometrioid carcinoma (OEC) remains controversial. Hence, the study sought to explore its value in stage I OEC patients. Methods: Stage I OEC patients (1988–2018) were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Multivariate Cox analysis was used to control confounders. Logistic regression was used to explore factors associated with adjuvant chemotherapy. Cox regression analysis and Kaplan-Meier curves were used to assess the survival benefits. Single-center clinical data and meta-analysis following PRISMA guidelines provided external validation. Result: Adjuvant chemotherapy correlated with improved survival (Hazard… More >

View

1177

Download

426

Open Access

ARTICLE

Jianwei Wang^1,2, Xinzhi Yang³, Lvbiao Lin⁴, Jianbo Yu^5,*, Jie Mao^4,*
Oncology Research, Vol.33, No.10, pp. 3023-3040, 2025, DOI:10.32604/or.2025.065380 - 26 September 2025
（This article belongs to the Special Issue: Novel Targets and Biomarkers in Solid Tumors)
Abstract Objectives: Glioma, as the most lethal primary brain malignancy with poor prognosis, requires further elucidation on the functional role of long noncoding RNA (lncRNA) DDX11 antisense RNA 1 (DDX11-AS1) in its pathogenesis, despite its established oncogenic functions in other cancers. Therefore, this study sought to characterize the oncogenic role and molecular mechanism of DDX11-AS1 in glioma. Methods: DDX11-AS1 expression levels were analyzed in clinical surgical glioma specimens and publicly available datasets. The functional roles of DDX11-AS1 on glioma cell proliferation and migration were investigated using in vitro knockdown and overexpression assays. In vivo tumor growth was assessed… More >

Graphic Abstract

View

1473

Download

243

Open Access

ARTICLE

Wenjing Liao^1,#, Liaodi Wang^2,#, Zhen Huang¹, Ziyu Zou¹, Yimin Liu¹, Haoyue Liu¹, Zhaoning Duan¹, Liangdan Tang^1,*
Oncology Research, Vol.33, No.10, pp. 3041-3064, 2025, DOI:10.32604/or.2025.065451 - 26 September 2025
（This article belongs to the Special Issue: Identification of potential targets and biomarkers for cancers and the exploration of novel molecular mechanisms of tumorigenesis and metastasis)
Abstract Objectives: Ovarian cancer (OC) is a highly heterogeneous disease characterized by high metastatic potential and frequent recurrence. 3β-hydroxysterol Δ24-reductase (DHCR24) is closely associated with the progression of various malignant tumors, but its role in OC remains unexplored. This study is the first to systematically investigate the function of DHCR24 in OC and elucidate its mechanism in promoting OC progression, providing novel theoretical insights for targeted therapy. Methods: The expression of DHCR24 was evaluated in tissues using bioinformatics and clinical data; the impact of DHCR24 on the malignant behavior of OC was assessed through in vivo and in… More >

View

1755

Download

324

Open Access

ARTICLE

Chuansheng Yang¹, Xiaoling Zhou^2,3, Ling Luo³, Zirun Luo⁴, Kaiming Fan^5,*, Chenglai Xia^2,3,*
Oncology Research, Vol.33, No.10, pp. 3065-3076, 2025, DOI:10.32604/or.2025.066058 - 26 September 2025
（This article belongs to the Special Issue: Recent Advances in Cancer Pharmacology)
Abstract Objectives: Novel drug delivery systems have been designed to enhance local drug concentrations while reducing side effects conducive to improved breast cancer treatment outcomes. This study aimed to identify the anti-cancer function of zeolite imidazole ester-based material loaded with camptothecin nanoparticles. Methods: We utilized a zeolitic imidazolate backbone material to fabricate 9-hydroxycamptothecin nanoparticles and investigated their impact on breast cancer cell proliferation. Scanning electron microscopy and Fourier-transform infrared spectroscopy revealed changes in the carrier skeleton of the loaded 9-hydroxyl camptothecin, characterized by a reduction in surface smoothness, accompanied by slight collapses and folds on the… More >

View

1806

Download

363

Open Access

ARTICLE

Mingyang Tang^1,2,#, Shengfu He^3,#, Bao Meng^1,2, Qingyue Zhang^1,2, Chengcheng Li^1,2, Yating Sun^1,2, Weijie Sun^1,2, Cui Wang⁴, Qingxiang Kong⁵, Yanyan Liu^1,2, Lifen Hu^1,2, Yufeng Gao^1,2, Qinxiu Xie^1,2, Jiabin Li^1,2,*, Ting Wu^1,2,*
Oncology Research, Vol.33, No.10, pp. 3077-3100, 2025, DOI:10.32604/or.2025.067065 - 26 September 2025
（This article belongs to the Special Issue: Identification of potential targets and biomarkers for cancers and the exploration of novel molecular mechanisms of tumorigenesis and metastasis)
Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths. The Nod-like receptor (NLR) family is involved in innate immunity and tumor progression, but its role in HCC remains unclear. This study aimed to evaluate the prognostic value and biological function of NLR genes in HCC. Methods: Transcriptomic and clinical data from The Cancer Genome Atlas were analyzed using nonnegative matrix factorization (NMF) to classify HCC into molecular subtypes. Differentially expressed genes were used to build an NLR-based prognostic model (NLR_score) through univariate Cox, least absolute shrinkage and selection operator (LASSO), and multivariate Cox… More >

Graphic Abstract

View

1973

Download

317

Open Access

ARTICLE

Songhua Bei^1,2,#, Qianqian Guo^1,#, Xinglei Wu^1,#, Fan Li^2,#, Yaya Xie³, Xiaohong Zhang^2,*, Li Feng^2,*, Xingxing Zhang^1,3,*
Oncology Research, Vol.33, No.10, pp. 3101-3125, 2025, DOI:10.32604/or.2025.067247 - 26 September 2025
（This article belongs to the Special Issue: Novel Biomarkers and Treatment Strategies in Solid Tumor Diagnosis, Progression, and Prognosis)
Abstract Background: Ferroptosis is a type of regulated cell death characterized by iron-dependent lipid peroxidation, which has been linked to tumor progression and therapeutic resistance. However, the contribution of lactate metabolism and its receptor, hydroxycarboxylic acid receptor 1 (HCAR1), in ferroptosis regulation in gastric cancer (GC) remains poorly understood. Focusing specifically on its effects on cell proliferation, ferroptosis regulation, and the disruption of lactate-mediated metabolic pathways, the study aimed to clarify the role of HCAR1 in GC progression. Methods: Bioinformatics analysis identified prognostic genes associated with ferroptosis in GC. Receiver operating characteristic (ROC) curves were generated… More >

View

2284

Download

1195

Open Access

ARTICLE

Jiayin Peng^1,2,#, Yijun Xue^2,#, Zhiren Cai², Zhaoguan Li², Kangyan Han², Xiaoqi Lin², Yutong Li^1,*, Yumin Zhuo^1,*
Oncology Research, Vol.33, No.10, pp. 3127-3154, 2025, DOI:10.32604/or.2025.067340 - 26 September 2025
（This article belongs to the Special Issue: Discover Biomarkers for Personalized Oncology)
Abstract Background: Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy associated with limited treatment options and poor prognosis. Emerging studies suggest that the actin-regulating protein actin-related protein 2/3 complex subunit 1B (ARPC1B), a key regulatory protein within the actin cytoskeleton, could play a pivotal role in ccRCC progression. The current study aimed to uncover the biological functions of ARPC1B and the molecular mechanisms driving its effects in ccRCC. Methods: ARPC1B expression and prognostic implications were analyzed using data sourced from the Gene Expression Profiling Interactive Analysis (GEPIA) platform, immunohistochemical (IHC) staining on 150 tumor… More >

View

2149

Download

1165

Open Access

RETRACTION

Oncology Research Editorial Office
Oncology Research, Vol.33, No.10, pp. 3155-3155, 2025, DOI:10.32604/or.2025.073032 - 26 September 2025
Abstract This article has no abstract. More >

View

1349

Download

1138

Open Access

RETRACTION

Oncology Research Editorial Office
Oncology Research, Vol.33, No.10, pp. 3157-3157, 2025, DOI:10.32604/or.2025.073033 - 26 September 2025
Abstract This article has no abstract. More >

View

1238

Download

1160

Open Access

RETRACTION

Oncology Research Editorial Office
Oncology Research, Vol.33, No.10, pp. 3159-3159, 2025, DOI:10.32604/or.2025.073035 - 26 September 2025
Abstract This article has no abstract. More >

View

1380

Download

1109