Open Access

REVIEW

Mitochondrial pyruvate dehydrogenase phosphatase metabolism disorder in malignant tumors

YUFENG WANG¹, HUIFENG DANG¹, QIANQIAN WANG¹, SHUXIAO WU¹, LEI HAN¹, XU LUO¹, YINGXIA TIAN^1,*, HAILIN TANG^2,*

1 Department of Breast Medical Oncology, Affiliated Cancer Hospital of Sun Yat-sen University, Gansu Hospital, Lanzhou, 730050, China
2 State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

* Corresponding Authors: YINGXIA TIAN. Email: ; HAILIN TANG. Email:

Oncology Research 2025, 33(8), 1861-1874. https://doi.org/10.32604/or.2025.063716

Received 22 January 2025; Accepted 17 March 2025; Issue published 18 July 2025

Abstract

This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase (PDP) in malignant tumors and its potential mechanisms. Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells, and potentially promotes tumor. Research has comprehensively explored the structural-functional characteristics of PDP, its metabolic regulatory mechanisms, and its role in various types of malignant tumors. Nevertheless, several questions still exist regarding its potential mechanisms within acetylation, phosphorylation, hypoxia, immune infiltration, mitochondrial metabolism, drug resistance, oxidative phosphorylation, and tumor prognosis. This article intends to summarize the latest research, examine PDP’s potential as a therapeutic target, and propose future research directions to enhance cancer treatment strategies.

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