Special Issues
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Advances and Innovations in Colorectal Cancer Research and Treatment

Submission Deadline: 31 May 2025 (closed) View: 1548 Submit to Journal

Guest Editors

Prof. Dr. Jaw-Yuan Wang

Email: cy614112@ms14.hinet.net

Affiliation: Department of Surgery and Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan 

Homepage:

Research Interests: Surgical and Molecular oncology, Colorectal cancer, Gastrointestinal malignancy and disease, Nutrition therapy, Robotic surgery, Microbiota 


Summary

Colorectal cancer is a significant health concern globally, being one of the leading causes of cancer-related deaths. It involves the development of cancerous growths in the colon or rectum, often stemming from polyps that become malignant over time. Despite advancements in detection and treatment, colorectal cancer remains a formidable challenge due to its complex nature and varied presentation.

 

This special issue on Colorectal Cancer aims to delve into the latest advancements and research in this critical field. This issue will encompass a broad range of topics, including early detection methods such as novel biomarkers and advanced imaging techniques, innovative treatment options like targeted therapies and immunotherapies, and insights into the molecular and genetic underpinnings of colorectal cancer. Additionally, the issue will explore the epidemiology of colorectal cancer, examining risk factors, preventive strategies, and disparities in healthcare access and outcomes.

 

This special issue seeks to bring together leading researchers and clinicians to share their findings and foster collaboration, ultimately aiming to improve patient outcomes and advance the field of oncology. By compiling cutting-edge research and expert insights, the issue aspires to be a valuable resource for oncologists, researchers, and policymakers.


Keywords

Colorectal cancer, Early detection, Targeted therapies, Molecular and genetic research, Epidemiology and prevention

Published Papers


  • Open Access

    ARTICLE

    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy

    Ping Wang, Yan-Han Chen, Ze-Tao Zhan, Jun-Xiang Zeng, Yu Chen, Yuan Lin, Tao Chen, Wei-Jie Zhou
    Oncology Research, DOI:10.32604/or.2025.071902
    (This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
    Abstract Background: Thimerosal is a mercury-containing preservative widely used in vaccines. This study aimed to investigate its potential antitumor effects and mechanisms in solid malignancies, particularly colorectal cancer (CRC) and melanoma. Methods: A combination of in vitro and in vivo approaches was employed. Cell proliferation, apoptosis, migration, and invasion were assessed using Cell Counting Kit-8 (CCK-8), colony formation, ATP viability, Western blotting, flow cytometry, wound-healing and Transwell assays. Subcutaneous, lung metastases, and Azoxymethane/Dextran Sulfate Sodium Salt (AOM/DSS)-induced colitis-associated CRC models were established to examine antitumor efficacy and safety. The functional role of mercury ions was validated using structural… More >

  • Open Access

    ARTICLE

    MYH11 Suppresses Colorectal Cancer Progression by Inhibiting Epithelial-Mesenchymal Transition via ZEB1 Regulation

    Yuhang Jiang, Yijun Xu, Qi Zhu, Yingxia Wu, Zhe Wang, Shuang He, Shiyong Yu, Honggang Xiang
    Oncology Research, Vol.33, No.9, pp. 2379-2398, 2025, DOI:10.32604/or.2025.063501
    (This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
    Abstract Background: Colorectal cancer (CRC) is common and deadly, often leading to metastasis, challenging treatment, and poor outcomes. Understanding its molecular basis is crucial for developing effective therapies. Aims: This study aimed to investigate the role of Myosin Heavy Chain 11 (MYH11) in CRC progression, especially its effects on epithelial-mesenchymal transition (EMT) and cell behavior, and to explore its potential regulation by the EMT transcription factor zinc finger E-box binding homeobox 1 (ZEB1). Methods: Differential expression analysis was performed in the GSE123390 and TCGA-READ datasets, and 317 intersection genes were identified. The hub gene MYH11 was identified… More >

  • Open Access

    ARTICLE

    Inhibition of Proteasome LMP2 Activity Suppresses Chil3 Expression in Mouse Colon Adenocarcinoma Tissue and Restrains Tumor Growth

    Tatiana M. Astakhova, Nikita S. Karpov, Nataliya O. Dashenkova, Elena V. Alpeeva, Mikhail V. Nesterchuk, Sergey B. Akopov, Arsen S. Mikaelyan, Anfisa S. Ryabchenko, Pavel A. Erokhov, Natalia P. Sharova
    Oncology Research, Vol.33, No.9, pp. 2573-2595, 2025, DOI:10.32604/or.2025.066611
    (This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
    Abstract Objectives: Proteasomes, multi-subunit proteases, are key actors of cellular protein catabolism and a number of regulatory processes. The detection of subtle proteasome functioning in tumors may contribute to our understanding of the mechanisms of cancer development. The current study aimed to identify the role of low molecular mass protein 2 (LMP2), a proteasome immune subunit, in the development of mouse colon 26 (C26) adenocarcinoma. Methods: The functions of the LMP2 subunit in tumor development in Balb/c mice were studied using its irreversible inhibitor KZR-504. LMP2 activity was detected by the hydrolysis of the fluorogenic substrate… More >

  • Open Access

    ARTICLE

    GPX4 predicts poor prognosis and regulates tumor proliferation and senescence in colorectal adenocarcinoma

    YU ZHANG, QINGKUN WANG, YUE HAN, JUNJIE PIAO, XIUYING JIN
    Oncology Research, Vol.33, No.8, pp. 1933-1945, 2025, DOI:10.32604/or.2025.063395
    (This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
    Abstract Background: Colorectal adenocarcinoma (COAD) is one of the most common gastrointestinal malignancies. There is a pressing need to recognize reliable biomarkers that can improve diagnostic accuracy, predict prognosis, and serve as effective molecular targets. Glutathione peroxidase 4 (GPX4) is an important antioxidant protein. Evidence demonstrates that abnormal expression of GPX4 is related to cancer initiation and progression. However, the role of GPX4 in COAD remains unclear. Methods: We employed bioinformatics analysis and conducted subsequent validation of biological processes, including cell counting kit-8 assay (CCK-8), colony formation assay, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), 5-ethynyl-2′-deoxyuridine assay… More >

  • Open Access

    ARTICLE

    USP13 Suppresses Colorectal Cancer Angiogenesis by Downregulating VEGFA Expression through Inhibition of the PTEN-AKT Pathway

    Guo-Zhi Xu, Han-Yang Guan, Yan-Guan Guo, Yi-Ran Zhang, Jing-Hua Pan, Simin Luo, Hui Ding, Yunlong Pan, Qi Yao
    Oncology Research, Vol.33, No.8, pp. 1947-1967, 2025, DOI:10.32604/or.2025.060440
    (This article belongs to the Special Issue: Advances and Innovations in Colorectal Cancer Research and Treatment)
    Abstract Background: Tumor angiogenesis is related to solid tumor occurrence. Ubiquitin-specific peptidase 13 (USP13) is a deubiquitinating enzyme with a pivotal effect on tumor proliferation, metastasis, and tumorigenesis. Nonetheless, its effect on colorectal cancer (CRC) angiogenesis remains poorly understood. Methods: Human umbilical vein endothelial cells (HUVECs) and CRC cells were cultivated, followed by USP13 knockdown/overexpression using shRNA lentiviral vectors or plasmids. Conditioned media (CM) from treated CRC cells were collected to assess HUVEC migration, invasion, and tube formation. Phosphatase and tensin homolog (PTEN) overexpression and recombinant vascular endothelial growth factor A (VEGFA) rescue experiments were performed.… More >

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