Special Issues

Role of Reactive Oxygen Species and DNA Damage in Tumor Immunological Responses

Submission Deadline: 30 June 2023 (closed) View: 29

Guest Editors

Muhammad Muddassir Ali, University of veterinary and animal sciences Lahore Pakistan, Pakistan. E-mail: Muddassir.ali@uvas.edu.pk
Ibrahim Hakki cigerci, Afyonkocatepe University, Afyonkarahisar Turkey. E-mail: cigerci@aku.edu.tr
Cherif ABDENNOUR, University Badji Mokhtar-Annaba, Annaba, Algeria. Email: cherifabdennour@yahoo.fr


Reactive oxygen species and free radicals lead to genotoxic effects and mutations. These cascades play pivotal role in the development of tumour and tumor immunological response. After exposure to exogenous and endogenous factors, DNA damage and repair response is initiated inside the cells. Various pathways like mismatch repair (MMR) pathway, non-homologous end joining (NHEJ) pathway nucleotide excision repair (NER) pathway, base excision repair (BER) pathway, and the homologous recombination (HR), etc are activated. Moreover, various signaling pathways are also involved and taken as biomarkers in the early diagnosis and treatment of various cancers, e.g., androgen receptor signaling pathway, hippo signaling, and HGF/Met pathway, etc. All these factors, pathways, and mechanisms play an important role in the diagnosis, prevention, and therapeutic applications of various tumors and understanding immunological response. Therefore, it is inevitable to explore and study biomarkers related to the oxidative stress, DNA damage, and repair involved in cancer diagnosis and treatment.

The aim of this Special Issue is to publish high-quality original research as well as review articles about the role of redox homeostasis in cancer biology, Epigenetic regulation of cancer, biomarkers for diagnosis of tumors, Tumor microenvironment, cytogenesis in tumor microenvironment and role of various biological biomarkers in tumor immunology.


DNA Damage, Neoplasms, Bioinformatics, Tumor microenvironment, Cancer treatment, Tumor micro environment, Tumour immunology, Oxidative stress

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