Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined in silico and in vitro approach
MUNEEBA MALIK, MAMOONA MAQBOOL, TOOBA NISAR, TAZEEM AKHTER, JAVED AHMED UJAN, ALANOOD S. ALGARNI, FAKHRIA A. AL JOUFI, SULTAN SHAFI K. ALANAZI, MOHAMMAD HADI ALMOTARED, MOUNIR M. SALEM BEKHIT, MUHAMMAD JAMIL
Oncology Research, Vol.31, No.6, pp. 899-916, 2023, DOI:10.32604/or.2023.030760
(This article belongs to this Special Issue:
Cancer Metastasis)
Abstract The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin
resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer
greater insight into drug resistance. To this end, a series of
in silico and
in vitro experiments were conducted to
identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes
involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information
(NCBI) database using search terms as “Kidney renal clear cell carcinoma” and “Cisplatin resistance”. The genes
retrieved were analyzed…
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