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ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling

XIA DA1, HAN GE2, JUNFENG SHI3, CHUNHUA ZHU1, GUOZHU WANG1, YUAN FANG4,*, JIN XU1,*

1 Department of Breast and Thyroid, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
2 Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
3 Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
4 Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China

* Corresponding Authors: YUAN FANG. Email: email; JIN XU. Email: email

(This article belongs to the Special Issue: Cancer Metastasis)

Oncology Research 2024, 32(7), 1209-1219. https://doi.org/10.32604/or.2024.045433

Abstract

Objective: This study aimed to investigate the role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in triple-negative breast cancer (TNBC). Methods: ROR2 expression in primary TNBC and metastatic TNBC tissues was analyzed by immunohistochemical staining and PCR. ROR2 expression in TNBC cell lines was detected by PCR and Western blot analysis. The migration, invasion and chemosensitivity of TNBC cells with overexpression or knockdown of ROR2 were examined. Results: ROR2 expression was high in metastatic TNBC tissues. ROR2 knockdown suppressed the migration, invasion and chemoresistance of TNBC cells. ROR2 overexpression in MDA-MB-435 cells promoted the migration, invasion, and chemoresistance. Moreover, ROR2 knockdown in HC1599 and MDA-MB-435 adriamycin-resistant cells enhanced chemosensitivity to adriamycin. ROR2 could activate PI3K/AKT/mTOR signaling in TNBC cells. Conclusion: ROR2 is upregulated and promotes metastatic phenotypes of TNBC by activating PI3K/AKT/mTOR signaling.

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APA Style
DA, X., GE, H., SHI, J., ZHU, C., WANG, G. et al. (2024). ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating pi3k/akt/mtor signaling. Oncology Research, 32(7), 1209-1219. https://doi.org/10.32604/or.2024.045433
Vancouver Style
DA X, GE H, SHI J, ZHU C, WANG G, FANG Y, et al. ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating pi3k/akt/mtor signaling. Oncol Res. 2024;32(7):1209-1219 https://doi.org/10.32604/or.2024.045433
IEEE Style
X. DA et al., "ROR2 promotes invasion and chemoresistance of triple-negative breast cancer cells by activating PI3K/AKT/mTOR signaling," Oncol. Res., vol. 32, no. 7, pp. 1209-1219. 2024. https://doi.org/10.32604/or.2024.045433



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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