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  • Open Access


    Silencing of ATP4B of ATPase H+/K+ Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells

    Shuye Lin*†, Bonan Lin*, Xiaoyue Wang*, Yuanming Pan, Qing Xu*, Jin-Shen He*, Wanghua Gong§, Rui Xing, Yuqi He, Lihua Guo*, Youyong Lu, Ji Ming Wang, Jiaqiang Huang*†

    Oncology Research, Vol.25, No.3, pp. 317-329, 2017, DOI:10.3727/096504016X14734735156265

    Abstract The ATPase H+/K+ Transporting Beta Subunit (ATP4B) encodes the b subunit of the gastric H+, K+ -ATPase, which controls gastric acid secretion and is therefore a target for acid reduction. Downregulation of ATP4B was recently observed in human gastric cancer (GC) without known mechanisms. In the present study, we demonstrated that ATP4B expression was decreased in human GC tissues and cell lines associated with DNA hypermethylation and histone hypoacetylation of histone H3 lysine 9 at its intragenic region close to the transcriptional start site. The expression of ATP4B was restored in GC cell lines by treatment with… More >

  • Open Access


    Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells

    Jin Zhang, Danjie Zhang, Liangzhang Sun

    Oncology Research, Vol.25, No.2, pp. 249-257, 2017, DOI:10.3727/096504016X693164

    Abstract Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes (DUBs), plays an essential role in the development of human carcinoma. However, to the best of our knowledge, the role of USP14 in esophageal squamous cell carcinoma (ESCC) is unknown. In the current study, we investigated the expression and role of USP14 in ESCC. Our results showed that the level of USP14 was significantly increased in ESCC tissues and cell lines. Downregulation of USP14 significantly inhibited ESCC cell proliferation and ESCC tumor growth in nude mice. Downregulation of USP14 also suppressed the migration/invasion in ESCC More >

  • Open Access


    Overexpression of MicroRNA-27b Inhibits Proliferation, Migration, and Invasion via Suppression of MET Expression

    Hui Zhou*†, Yanglin Liu, Ling Xiao, Zhengmao Hu*, Kun Xia

    Oncology Research, Vol.25, No.1, pp. 147-154, 2017, DOI:10.3727/096504016X14732772150505

    Abstract MicroRNA-27b (miR-27b) was recently found to be significantly downregulated in different human cancers. However, evidence of the function of miR-27b in non-small cell lung cancer (NSCLC) remains limited. In this study, we aimed to investigate novel miR-27b-mediated targets or signaling pathways associated with the tumorigenesis and metastasis of NSCLC. Real-time (RT) PCR was performed to examine miR-27b expression in NSCLC specimens. MTT assay, wound-healing assay, and Transwell assay were used to determine cell proliferation, migration, and invasion. Our data indicated that the miR-27b levels were significantly decreased in NSCLC specimens and cell lines (SK-MES-1, H358,… More >

  • Open Access


    Knockdown of Tripartite Motif-Containing Protein 37 (TRIM37) Inhibits the Proliferation and Tumorigenesis in Colorectal Cancer Cells

    Ping Zhao*, Hai-Tao Guan, Zhi-Jun Dai, Yu-Guang Ma, Xiao-Xu Liu, Xi-Jing Wang

    Oncology Research, Vol.25, No.1, pp. 115-122, 2017, DOI:10.3727/096504016X14732772150181

    Abstract Tripartite motif-containing protein 37 (TRIM37), a new member of the RING-B-box-coiled-coil (RBCC) subfamily of zinc finger proteins, was found to be involved in the development and progression of several cancers. However, the expression pattern and biological functions of TRIM37 in colorectal cancer (CRC) remain unknown. Therefore, in the present study, we examined the expression pattern of TRIM37 in CRC and investigated the function of TRIM37 in the progression of CRC. Our results showed that TRIM37 expression was upregulated in CRC cell lines. Knockdown of TRIM37 inhibited CRC cell proliferation and tumor growth in vivo. Furthermore, More >

  • Open Access


    Tumor Necrosis Factor (TNF)-α-Induced Protein 8-like-2 (TIPE2) Inhibits Proliferation and Tumorigenesis in Breast Cancer Cells

    Ke Wang, Yu Ren, Yang Liu, Jian Zhang, Jian-jun He

    Oncology Research, Vol.25, No.1, pp. 55-63, 2017, DOI:10.3727/096504016X14719078133320

    Abstract Tumor necrosis factor-a (TNF-a)-induced protein 8-like-2 (TNFAIP8L2 or TIPE2), a member of the tumor necrosis TNFAIP8 family, was found to be involved in the development and progression of several tumors. However, to date, the role of TIPE2 in breast cancer is still unclear. Thus, the aim of this study is to explore the role of TIPE2 in breast cancer. Our results indicated that TIPE2 expression was significantly decreased in human breast cancer tissue and cell lines. Overexpression of TIPE2 inhibited the proliferation in vitro and tumor xenograft growth in vivo. TIPE2 also inhibited the migration/invasion More >

  • Open Access


    MicroRNA-331 Inhibits Proliferation and Invasion of Melanoma Cells by Targeting Astrocyte-Elevated Gene-1

    Li Chen, Guozhang Ma, Xiaohui Cao, Xiaoxia An, Xiguang Liu

    Oncology Research, Vol.26, No.9, pp. 1429-1437, 2018, DOI:10.3727/096504018X15186047251584

    Abstract Melanoma is characterized by aggressive invasion, early metastasis, and resistance to existing chemotherapeutic agents. Accumulated studies have reported that microRNA (miRNA) is a potentially robust molecular tool for developing future therapeutic technologies. Therefore, examining the expression patterns, biological roles, and associated mechanisms of cancer-related miRNAs in melanoma is essential for developing novel therapeutic targets for patients with this disease. In this study, miRNA-331 (miR-331) was underexpressed in melanoma tissues and cell lines. Functional assays revealed that the enforced expression of miR-331 inhibited cell proliferation and invasion. In addition, astrocyte-elevated gene-1 (AEG-1) was identified as a More >

  • Open Access


    MicroRNA-744 Inhibits Cellular Proliferation and Invasion of Colorectal Cancer by Directly Targeting Oncogene Notch1

    Jian Shen, Minzhe Li

    Oncology Research, Vol.26, No.9, pp. 1401-1409, 2018, DOI:10.3727/096504018X15188747585738

    Abstract Accumulated studies have strongly implicated aberrantly expressed microRNAs (miRNAs) in carcinogenesis and cancer progression of various cancers, including colorectal cancer (CRC). Hence, a comprehensive study of miRNAs and their association with CRC may be a promising therapeutic method for patients with this malignancy. MicroRNA-744 (miR-744) is abnormally expressed in several types of human cancer. Thus far, little is known about the expression, biological roles, and exact mechanisms of miR-744 in CRC. Thus, the present study measured the expression level of miR-744 and investigated its roles and associated molecular mechanisms in CRC. This study demonstrated that… More >

  • Open Access


    Long Noncoding RNA FGFR3-AS1 Promotes Hepatocellular Carcinoma Carcinogenesis via Modulating the PI3K/AKT Pathway

    Juhua Zhuang*1, Saifei He*1, Guoyu Wang*, Guangdong Wang*†, Jing Ni*, Suiliang Zhang, Ying Ye*, Wei Xia*

    Oncology Research, Vol.26, No.8, pp. 1257-1265, 2018, DOI:10.3727/096504018X15172756878992

    Abstract Hepatocellular carcinoma (HCC) as one of the most refractory cancers leads to high mortality worldwide. Long noncoding RNAs have been widely acknowledged as important biomarkers and therapeutic targets in HCC. In this study, we investigated the effects of long noncoding RNA FGFR3-AS1 on tumor growth and metastasis in HCC. First, we found that the expression of FGFR3-AS1 was upregulated about threefold in HCC samples and cell lines. We knocked down FGFR3-AS1 in Huh7 and Hep3B cells and found that FGFR3-AS1 knockdown significantly inhibited cell proliferation but induced apoptosis. Moreover, FGFR3-AS1 knockdown led to more HCC More >

  • Open Access


    ShCTR1 Interacts with ShRBOH1 to Positively Regulate Aerenchyma Formation in Saussurea inversa through ROS Mediation

    Wubin Dai1, Xiuting Ju1,2, Guomin Shi1,2, Jialei Guo3,4, Tao He3,4,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 1023-1042, 2024, DOI:10.32604/phyton.2024.050066

    Abstract Saussurea inversa is one of the Tibetan medicine with developed aerenchyma. In this study, we investigated the function of the ShCTR1 gene related to the formation of aerenchyma. The study of the occurrence and formation of aerenchyma in S. inversa has certain theoretical significance in revealing the special mechanism of alpine plants adapting to the environment. The results of yeast two-hybrid experiments showed that S. inversa ShCTR1 interacted with the ShRBOH1, which is a key producer of reactive oxygen species (ROS), and it was hypothesized that ShCTR1 regulation of aerenchyma formation in S. inversa mainly mediated by ROS. Aerenchyma induction and… More >

  • Open Access


    Coffee Leaf Rust (Hemileia vastatrix) Disease in Coffee Plants and Perspectives by the Disease Control

    Alexis Salazar-Navarro1, Victor Ruiz-Valdiviezo2, Jose Joya-Dávila3, Daniel Gonzalez-Mendoza1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 923-949, 2024, DOI:10.32604/phyton.2024.049612

    Abstract Coffee Leaf Rust (CLR) is caused by Hemileia vastatrix in Coffea spp. It is one of the most dangerous phytopathogens for coffee plantations in terms of coffee productivity and coffee cup quality. In this review, we resume the problem of CLR in Mexico and the pathogenesis of H. vastatrix. The review abord plant-pathogen interactions which lead a compatible or incompatible interactions and result in CLR disease or resistance, respectively. The review abord Coffea spp. defense response pathways involved in H. vastatrix pathogenicity. Additionally, current measures to control H. vastatrix proliferation and germination were aborded focused on phytosanitary actions, and biological More >

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