Yifan Li^1,#, Xu Huang^2,#, Bingyu Ma³, Ling Sun¹, Shushui Wang¹, Zhiwei Zhang¹, Yumei Xie^1,*

Congenital Heart Disease, Vol.20, No.4, pp. 463-475, 2025, DOI:10.32604/chd.2025.068286 - 18 September 2025

Abstract Objective: The aim of the present study was to investigate long-term efficacy and safety of percutaneous stent implantation for residual pulmonary artery stenosis (PAS) in pediatric patients after surgical repair of complicated congenital heart diseases (CHDs). Methods: All pediatric patients diagnosed with residual PAS after surgical repair of complicated CHDs between 1996 and 2020 were retrospectively enrolled in the study. Results: A total of 41 patients (30 males, 11 females; median age 5.0 years, median weight 17 kg) were followed-up for a median of 7.1 years. Follow-up echocardiography results demonstrated that the target vessel diameter increased from… More >

Mai Ishiwata^1,2, Kohei Ishibashi^1,*, Yoshiaki Kato³, Heima Sakaguchi³, Toshihiro Nakamura¹, Satoshi Oka¹, Yuichiro Miyazaki¹, Akinori Wakamiya¹, Nobuhiko Ueda¹, Kenzaburo Nakajima¹, Tsukasa Kamakura¹, Mitsuru Wada¹, Yuko Inoue¹, Koji Miyamoto¹, Takeshi Aiba¹, Norihiko Takeda², Kengo Kusano¹

Congenital Heart Disease, Vol.20, No.3, pp. 273-286, 2025, DOI:10.32604/chd.2025.067716 - 11 July 2025

Abstract Background: Ventricular arrhythmia is a common cause of mortality in adult congenital heart disease (ACHD). The beneficial effects of implantable cardioverter-defibrillators (ICD) in patients with ACHD have been demonstrated; however, evidence on this topic remains insufficient. This study aimed to assess the long-term outcomes after ICD implantation in the ACHD population. Methods: We retrospectively reviewed 35 consecutive patients with ACHD who underwent ICD implantation between December 2012 and August 2022. ICD implantation was classified as primary or secondary prevention. The long-term outcomes, including all-cause mortality, appropriate and inappropriate ICD therapy, and complications related to ICD implantation, were… More > Graphic Abstract

Roberto Noya Galluzzo¹, Karine Souza Da Correggio¹, Aldo von Wangenheim², Heron Werner³, Nathalie Jeanne Bravo-Valenzuela⁴, Edward Araujo Júnior^5,6,*, Alexandre Sherlley Casimiro Onofre⁷

Congenital Heart Disease, Vol.20, No.1, pp. 89-101, 2025, DOI:10.32604/chd.2025.063014 - 18 March 2025

Abstract Introduction: Diabetes mellitus (DM), a metabolic disorder, leads to organ damage due to chronic hyperglycemia with multiple pathogenic processes. Gestational diabetes mellitus (GDM) poses risks to mothers and offspring, increasing the incidence of structural congenital heart disease (CHD) and myocardial hypertrophy in newborns. Objective: This review aimed to examine the association between maternal diabetes mellitus and CHD. Methods: This systematic review used the STROBE and TRIPOD checklists registered in PROSPERO (CRD42024513858). It focused on diagnostic test accuracy using the Munn et al. protocol for systematic assessment, emphasizing the “PIRD”: Population, Index Test, Reference Test, Diagnosis of Interest.… More >

Abbas Ali Hassan, Fardin Abdali-Mohammadi^*

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 971-983, 2024, DOI:10.32604/cmc.2024.053817 - 15 October 2024

Abstract From a medical perspective, the 12 leads of the heart in an electrocardiogram (ECG) signal have functional dependencies with each other. Therefore, all these leads report different aspects of an arrhythmia. Their differences lie in the level of highlighting and displaying information about that arrhythmia. For example, although all leads show traces of atrial excitation, this function is more evident in lead II than in any other lead. In this article, a new model was proposed using ECG functional and structural dependencies between heart leads. In the prescreening stage, the ECG signals are segmented from… More >

Deema Mohammed Alsekait¹, Ahmed Younes Shdefat², Ayman Nabil³, Asif Nawaz^4,*, Muhammad Rizwan Rashid Rana⁴, Zohair Ahmed⁵, Hanaa Fathi⁶, Diaa Salama AbdElminaam^6,7,8

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3967-3990, 2024, DOI:10.32604/cmc.2024.054591 - 12 September 2024

Abstract Heart disease remains a leading cause of morbidity and mortality worldwide, highlighting the need for improved diagnostic methods. Traditional diagnostics face limitations such as reliance on single-modality data and vulnerability to apparatus faults, which can reduce accuracy, especially with poor-quality images. Additionally, these methods often require significant time and expertise, making them less accessible in resource-limited settings. Emerging technologies like artificial intelligence and machine learning offer promising solutions by integrating multi-modality data and enhancing diagnostic precision, ultimately improving patient outcomes and reducing healthcare costs. This study introduces Heart-Net, a multi-modal deep learning framework designed to… More >

Shuliang Xia^1,2,3,#, Huikang Tao^2,#, Shixin Su⁴, Xinxin Chen², Li Ma², Jianru Li⁵, Bei Gao⁶, Xumei Liu⁵, Lei Pi⁷, Jinqing Feng⁴, Fengxiang Li², Jia Li^4,*, Zhiwei Zhang^1,3,*

Congenital Heart Disease, Vol.19, No.2, pp. 247-256, 2024, DOI:10.32604/chd.2024.052583 - 16 May 2024

Abstract Aims: Multiple genes and environmental factors are known to be involved in congenital heart disease (CHD), but epigenetic variation has received little attention. Monozygotic (MZ) twins with CHD provide a unique model for exploring this phenomenon. In order to investigate the potential role of Deoxyribonucleic Acid (DNA) methylation in CHD pathogenesis, the present study examined DNA methylation variation in MZ twins discordant for CHD, especially ventricular septal defect (VSD). Methods and Results: Using genome-wide DNA methylation profiles, we identified 4004 differentially methylated regions (DMRs) in 18 MZ twin pairs discordant for CHD, and 2826 genes were… More > Graphic Abstract

Fatma Nese Efil¹, Sania Qureshi^1,2,3, Nezihal Gokbulut^1,4, Kamyar Hosseini^1,3, Evren Hincal^1,4,*, Amanullah Soomro²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 485-512, 2024, DOI:10.32604/cmes.2024.047907 - 16 April 2024

Abstract The global population has been and will continue to be severely impacted by the COVID-19 epidemic. The primary objective of this research is to demonstrate the future impact of COVID-19 on those who suffer from other fatal conditions such as cancer, heart disease, and diabetes. Here, using ordinary differential equations (ODEs), two mathematical models are developed to explain the association between COVID-19 and cancer and between COVID-19 and diabetes and heart disease. After that, we highlight the stability assessments that can be applied to these models. Sensitivity analysis is used to examine how changes in… More >

Fu Guan^1,*, Matthias Gass², Florian Berger², Heiko Schneider¹, Firat Duru^1,3, Thomas Wolber^1,3,*

Congenital Heart Disease, Vol.19, No.1, pp. 85-92, 2024, DOI:10.32604/chd.2024.047266 - 20 March 2024

Abstract Aims: Although the application of ultrasound-guided vascular puncture and Z-stitch hemostasis to manage femoral access has been widely utilized, there is limited data on this combined application in adult congenital heart disease (ACHD) patients undergoing electrophysiological (EP) procedures. We sought to evaluate the safety and efficacy of ultrasound-guided puncture and postprocedural Z-stitch hemostasis for ACHD patients undergoing EP procedures. Methods and Results: The population of ACHD patients undergoing transfemoral EP procedures at the University of Zurich Heart Center between January 2019 and December 2022 was observed and analyzed. During the study period, femoral access (left/right, arterial/venous)… More >

Wenlei Qian^1,#, Xinzhu Zhou^2,#, Ke Shi¹, Li Jiang¹, Xi Liu³, Liting Shen¹, Zhigang Yang^1,*

Congenital Heart Disease, Vol.18, No.1, pp. 113-125, 2023, DOI:10.32604/chd.2023.023542 - 09 January 2023

Abstract Background: Pulmonary atresia (PA) is a group of heterogeneous complex congenital heart disease. Only one study modality might not get a correct diagnosis. This study aims to investigate the diagnostic power of dual-source computed tomography (DSCT) for all intracardiac and extracardiac deformities in patients with PA compared with transthoracic echocardiography (TTE). Materials and Methods: This retrospective study enrolled 79 patients and divided them into three groups according to their main diagnosis. All associated malformations and clinical information, including treatments, were recorded and compared among the three groups. The diagnostic power of DSCT and TTE on all associated… More > Graphic Abstract

Batyrkhan Omarov^1,2,*, Nurbek Saparkhojayev², Shyrynkyz Shekerbekova³, Oxana Akhmetova¹, Meruert Sakypbekova¹, Guldina Kamalova³, Zhanna Alimzhanova¹, Lyailya Tukenova³, Zhadyra Akanova⁴

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 2815-2833, 2022, DOI:10.32604/cmc.2022.019246 - 27 September 2021

Abstract Diseases of the cardiovascular system are one of the major causes of death worldwide. These diseases could be quickly detected by changes in the sound created by the action of the heart. This dynamic auscultations need extensive professional knowledge and emphasis on listening skills. There is also an unmet requirement for a compact cardiac condition early warning device. In this paper, we propose a prototype of a digital stethoscopic system for the diagnosis of cardiac abnormalities in real time using machine learning methods. This system consists of three subsystems that interact with each other (1)… More >