NIMA HEMMAT1, MOHAMMAD AMIN DOUSTVANDI1, ZAHRA ASADZADEH1, AHAD MOKHTARZADEH1, BEHZAD BARADARAN1,4,*, HOSSEIN BANNAZADEH BAGHI1,2,3,*
Oncology Research, Vol.29, No.2, pp. 141-148, 2021, DOI:10.32604/or.2022.023346
Abstract Cervical cancer is a growing global disease in developing countries. Persistent infection with human
papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5
oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling
pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA
to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle,
apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results
demonstrate that… More >
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