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Suppression of human papillomavirus type 16 E5 oncoprotein: A promising step in fostering the treatment of cervical cancer

NIMA HEMMAT1, MOHAMMAD AMIN DOUSTVANDI1, ZAHRA ASADZADEH1, AHAD MOKHTARZADEH1, BEHZAD BARADARAN1,4,*, HOSSEIN BANNAZADEH BAGHI1,2,3,*

1 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

* Corresponding Authors: Hossein Bannazadeh Baghi, email; Behzad Baradaran, email

Oncology Research 2021, 29(2), 141-148. https://doi.org/10.32604/or.2022.023346

Abstract

Cervical cancer is a growing global disease in developing countries. Persistent infection with human papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5 oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results demonstrate that E5 plays an essential role in the proliferation and inhibited apoptosis in cervical cancer. Furthermore, silencing E5 reduces proliferation, increases apoptosis, and elevates related-genes expression of these malignant cells. Overall, E5 suppression may be appropriate for ameliorating cervical cancer progression.

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Cite This Article

HEMMAT, N., DOUSTVANDI, M. A., ASADZADEH, Z., MOKHTARZADEH, A., BARADARAN, B. et al. (2021). Suppression of Human Papillomavirus Type 16 E5 Oncoprotein: A Promising Step in Fostering the Treatment of Cervical Cancer. Oncology Research, 29(2), 141–148.



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