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  • Open Access

    ARTICLE

    Investigating Periodic Dependencies to Improve Short-Term Load Forecasting

    Jialin Yu1,*, Xiaodi Zhang2, Qi Zhong1, Jian Feng1

    Energy Engineering, Vol.121, No.3, pp. 789-806, 2024, DOI:10.32604/ee.2023.043299

    Abstract With a further increase in energy flexibility for customers, short-term load forecasting is essential to provide benchmarks for economic dispatch and real-time alerts in power grids. The electrical load series exhibit periodic patterns and share high associations with metrological data. However, current studies have merely focused on point-wise models and failed to sufficiently investigate the periodic patterns of load series, which hinders the further improvement of short-term load forecasting accuracy. Therefore, this paper improved Autoformer to extract the periodic patterns of load series and learn a representative feature from deep decomposition and reconstruction. In addition, a novel multi-factor attention mechanism… More >

  • Open Access

    ARTICLE

    Immune checkpoint receptors and their ligands on CD8 T cells and myeloma cells in extramedullary multiple myeloma

    XIAN ZHANG1, ZHUANG ZHOU2, JUNZHE WANG1, MENGMENG HAN1, HAN LIU1, MEIRONG ZANG1, JIANNING LIU1, JIAPEI LU1, JINQIAO ZHANG1, GUOCHUAN ZHANG2,*, LIXIA SUN1,#,*

    BIOCELL, Vol.48, No.2, pp. 303-311, 2024, DOI:10.32604/biocell.2023.046640

    Abstract Background: Prognosis of multiple myeloma (MM) patients with extramedullary disease (EMD) remains poor. T cell dysfunction and an immunosuppressive environment have been reported in the bone marrow (BM) of MM patients. However, the immunosuppressive microenvironment and immune checkpoint receptors (ICRs) on CD8 T cells in the EMD tissue of newly diagnosed MM (NDMM) patients have not been thoroughly studied. Methods: We investigated the expression levels of T cell immunoglobulin mucin-domain-containing-3 (TIM-3) and T-cell immunoglobulin and ITIM domain (TIGIT) on CD8 T cells and the expression of their ligands (Galectin-9 and CD155) on myeloma cells in EMD tissue of NDMM patients.… More > Graphic Abstract

    Immune checkpoint receptors and their ligands on CD8 T cells and myeloma cells in extramedullary multiple myeloma

  • Open Access

    ARTICLE

    Overexpression of RUNX1 mitigates dexamethasone-induced impairment of osteogenic differentiation and oxidative stress injury in bone marrow mesenchymal stem cells by promoting alpha-2 macroglobulin transcription

    QINGJIAN HE1, HUIXIN ZHU2,3, SHANHONG FANG4,5,*

    BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109

    Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression by kits, OD by alkaline… More >

  • Open Access

    ARTICLE

    E3 ubiquitin ligase CBL-B suppresses vascular endothelial cell pyroptosis and injury in intracranial aneurysm by facilitating NLRP3 degradation

    WEI ZHENG1, CHENG LIU2,*

    BIOCELL, Vol.48, No.2, pp. 293-301, 2024, DOI:10.32604/biocell.2023.044211

    Abstract Objective: Intracranial aneurysm (IA) represents a devastating disease with high rates of disability and mortality, which is initiated by dysfunction of endothelial cells (ECs). Evidence suggests the dysregulation of the E3 ubiquitin ligase family during EC injury. In this work, the role of an E3 ubiquitin ligase, casitas B lymphoma-B (CBL-B), was explored in human brain microvascular EC (HBMEC) function through the NLRP3 pathway. Methods: In vitro IA model was induced by treating HBMECs with oxidized low-density lipoprotein (ox-LDL). The levels of CBL-B and pyroptosis-related proteins NLRP3, ASC, cleaved caspase-1, and GSDME-N were determined by real-time-quantitative polymerase chain reaction and… More >

  • Open Access

    ARTICLE

    Finite Element Simulation Analysis of a Novel 3D-FRSPA for Crawling Locomotion

    Bingzhu Wang1,*, Xiangrui Ye2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1401-1425, 2024, DOI:10.32604/cmes.2024.047364

    Abstract A novel three-dimensional-fiber reinforced soft pneumatic actuator (3D-FRSPA) inspired by crab claw and human hand structure that can bend and deform independently in each segment is proposed. It has an omni-directional bending configuration, and the fibers twined symmetrically on both sides to improve the bending performance of FRSPA. In this paper, the static and kinematic analysis of 3D-FRSPA are carried out in detail. The effects of fiber, pneumatic chamber and segment length, and circular air chamber radius of 3D-FRSPA on the mechanical performance of the actuator are discussed, respectively. The soft mobile robot composed of 3D-FRSPA has the ability to… More >

  • Open Access

    ARTICLE

    Evaluating the Efficacy of Latent Variables in Mitigating Data Poisoning Attacks in the Context of Bayesian Networks: An Empirical Study

    Shahad Alzahrani1, Hatim Alsuwat2, Emad Alsuwat3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1635-1654, 2024, DOI:10.32604/cmes.2023.044718

    Abstract Bayesian networks are a powerful class of graphical decision models used to represent causal relationships among variables. However, the reliability and integrity of learned Bayesian network models are highly dependent on the quality of incoming data streams. One of the primary challenges with Bayesian networks is their vulnerability to adversarial data poisoning attacks, wherein malicious data is injected into the training dataset to negatively influence the Bayesian network models and impair their performance. In this research paper, we propose an efficient framework for detecting data poisoning attacks against Bayesian network structure learning algorithms. Our framework utilizes latent variables to quantify… More >

  • Open Access

    ARTICLE

    Investigations on High-Speed Flash Boiling Atomization of Fuel Based on Numerical Simulations

    Wei Zhong1, Zhenfang Xin2, Lihua Wang1,*, Haiping Liu2

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1427-1453, 2024, DOI:10.32604/cmes.2023.031271

    Abstract Flash boiling atomization (FBA) is a promising approach for enhancing spray atomization, which can generate a fine and more evenly distributed spray by increasing the fuel injection temperature or reducing the ambient pressure. However, when the outlet speed of the nozzle exceeds 400 m/s, investigating high-speed flash boiling atomization (HFBA) becomes quite challenging. This difficulty arises from the involvement of many complex physical processes and the requirement for a very fine mesh in numerical simulations. In this study, an HFBA model for gasoline direct injection (GDI) is established. This model incorporates primary and secondary atomization, as well as vaporization and… More >

  • Open Access

    ARTICLE

    Silicon Mitigates Aluminum Toxicity of Tartary Buckwheat by Regulating Antioxidant Systems

    Anyin Qi1,#, Xiaonan Yan1,#, Yuqing Liu1,#, Qingchen Zeng1, Hang Yuan1, Huange Huang1, Chenggang Liang2, Dabing Xiang1, Liang Zou1, Lianxin Peng1, Gang Zhao1, Jingwei Huang1,*, Yan Wan1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 1-13, 2024, DOI:10.32604/phyton.2023.045802

    Abstract

    Aluminum (Al) toxicity is a considerable factor limiting crop yield and biomass in acidic soil. Tartary buckwheat growing in acidic soil may suffer from Al poisoning. Here, we investigated the influence of Al stress on the growth of tartary buckwheat seedling roots, and the alleviation of Al stress by silicon (Si), as has been demonstrated in many crops. Under Al stress, root growth (total root length, primary root length, root tips, root surface area, and root volume) was significantly inhibited, and Al and malondialdehyde (MDA) accumulated in the root tips. At the same time, catalase (CAT) and ascorbate peroxidase activities,… More >

  • Open Access

    PROCEEDINGS

    Thermodynamic Investigation with Synergetic Method on Inner Crack Growth Behavior at very High Cycle Fatigue Regime

    Yujia Liu1,2, Bo Xu1, Sen Tang3, Lang Li1, Chao He1, Qingyuan Wang1,2,3, Chong Wang1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.010057

    Abstract This paper presents a thermodynamic characterization method for estimating the internal crack growth rate, which has been a puzzle in very high cycle fatigue research. A theoretical approach of surface temperature is established with crack size, initiation site, and time for thin sheet material. Infrared thermography is used to study the inner crack behavior and the heat dissipation phenomenon under 20 kHz vibration loading on high-strength stainless steel. A numerical simulation reveals the consequent temperature elevation on the surfaces by the heat generation at the crack tip and the heat conduction. Ultimately, the internal crack growth rate and final fatigue… More >

  • Open Access

    PROCEEDINGS

    Investigation of Pore-Scale THMC Acid Fracturing Process Considering Heat Conduction Anisotropy

    Kaituo Jiao1, Dongxu Han2,*, Bo Yu2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.4, pp. 1-5, 2023, DOI:10.32604/icces.2023.09168

    Abstract Acid fracturing is critical to improving the connectivity inside underground reservoirs, which involves a complex thermal-hydro-mechanical-chemical (THMC) coupling process, especially deep underground. Heat conduction anisotropy is one of the intrinsic properties of rock. It determines the heat response distribution inside the rock and alters the temperature evolution on the reactive surface of fractures and pores. In another way, the rock dissolution rate is closely related to the reactive surface temperature. Predictably, heat conduction anisotropy leads to different rock dissolution morphologies from that of the heat conduction isotropy situation, then the cracks distribution and permeability of rock would also be significantly… More >

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