Chee Chin Lim1,2,*, Hui Wen Tiu1, Qi Wei Oung1,3, Chiew Chea Lau4, Xiao Jian Tan2,5
CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.070468
- 12 January 2026
Abstract Breast cancer remains one of the leading causes of cancer mortality world-wide, with accurate molecular subtyping is critical for guiding treatment and improving patient outcomes. Traditional molecular subtyping via immuno-histochemistry (IHC) test is invasive, time-consuming, and may not fully represent tumor heterogeneity. This study proposes a non-invasive approach using digital mammography images and deep learning algorithm for classifying breast cancer molecular subtypes. Four pretrained models, including two Convolutional Neural Networks (MobileNet_V3_Large and VGG-16) and two Vision Transformers (ViT_B_16 and ViT_Base_Patch16_Clip_224) were fine-tuned to classify images into HER2-enriched, Luminal, Normal-like, and Triple Negative subtypes. Hyperparameter tuning,… More >