Ryan Daigle¹, Ilene Staff², Joseph Tortora², Tara McLaughlin Proto^3,*, Kevin Pinto³, Rosa Negron², Jonathan Earle⁴, Joseph Wagner,³

Canadian Journal of Urology, Vol.32, No.3, pp. 189-198, 2025, DOI:10.32604/cju.2025.063773 - 27 June 2025

Abstract Introduction: We examined the pathology and safety outcomes associated with the extent of pelvic lymph node dissection in patients with high-risk prostate cancer undergoing radical prostatectomy. Materials and Methods: We retrospectively identified men with prostate cancer who underwent robot-assisted radical prostatectomy with pelvic lymph node dissection between May 2016 and September 2021. Cases were categorized using Current Procedural Terminology (CPT) codes (38571) for extended lymph node dissection and super-extended lymph node dissection (38572). Using logistic regression, we compared the groups on a number of factors, including recurrence. Results: Super-extended lymph node dissection had significantly higher median… More >

María Belén Rocco, Clara Requena D’Alessio, Valeria Giselle Sánchez, Horacio Eduardo Romeo, María Laura Barreiro Arcos^*

BIOCELL, Vol.49, No.4, pp. 629-646, 2025, DOI:10.32604/biocell.2025.062525 - 30 April 2025

Abstract Introduction: Hyperthyroidism is known to affect various physiological systems, including the immune system. Thyroid hormones (THs) play a crucial role in regulating immune function, and alterations in THs levels can lead to immune dysregulation. Objective: Currently, we aimed to elucidate the effects of hyperthyroidism on immune function in BALB/c mice, with a focus on anatomical and histological changes in lymphoid organs, the immune response to mitogenic stimulation, mitochondrial dynamics, and reactive oxygen species (ROS) production. Methods: Hyperthyroidism was induced in BALB/c mice by administering thyroxine (T4; 14 mg/L) in their drinking water for 30 days. Thyroid… More >

ZHENGYANG ZHOU^1,#, LEI QIAO^1,#, TONGTONG WANG¹, WEN PAN¹, JINGJING DUAN¹, HAIYANG ZHANG², TING DENG¹, YI BA^1,*, YI HE^1,*

Oncology Research, Vol.33, No.2, pp. 327-345, 2025, DOI:10.32604/or.2024.050431 - 16 January 2025

Abstract Background: Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC. Nowadays, more and more studies have confirmed that exosomes can participate in tumor lymphangiogenesis. An in-depth exploration of the pathological mechanism in the process of LNM in GC may provide effective targets and improve the diagnosis and treatment effect. Materials and Methods: We used sequencing analysis of collected serum to screen out exo-miRNA related to LNM in GC. ELISA, qRT-PCR, Western Blot, RNA pull-down assay, Transwell assay, animal experiments, and other… More > Graphic Abstract

JUN SHEN^1,#, HONGFANG MA^2,#, YONGXIA CHEN³, JIANGUO SHEN^1,*

Oncology Research, Vol.31, No.6, pp. 955-966, 2023, DOI:10.32604/or.2023.029638 - 15 September 2023

Abstract The process of lymphatic metastasis was proved to be associated with podoplanin-expressing macrophages in breast cancer (BC). This study aimed to investigate the role of the M2 phenotype of tumor-associated macrophages and mine the key M2 macrophages-related genes for lymph node metastasis in BC. We downloaded the GSE158399 dataset from the Gene Expression Omnibus (GEO) database, which includes transcriptomic profiles of individual cells from primary tumors, negative lymph nodes (NLNs), and positive lymph nodes (PLNs) of breast cancer patients. The cell subsets were identified by clustering analysis after quality control of the scRNA-seq using Seurat.… More >

FERDINANDO CALABRIA¹, ANTONIO BAGNATO¹, GIULIANA GUADAGNINO², MARIA TOTEDA¹, ANTONIO LANZILLOTTA¹, STEFANIA CARDEI¹, ROSANNA TAVOLARO¹, MARIO LEPORACE^1,*

Oncology Research, Vol.31, No.2, pp. 117-124, 2023, DOI:10.32604/or.2023.027705 - 10 April 2023

Abstract We observed several patients presenting 2-[¹⁸F]FDG uptake in the reactive axillary lymph node at PET/CT imaging, ipsilateral to the site of the COVID-19 vaccine injection. Analog finding was documented at [¹⁸F]Choline PET/CT. The aim of our study was to describe this source of false positive cases. All patients examined by PET/CT were included in the study. Data concerning patient anamnesis, laterality, and time interval from recent COVID-19 vaccination were recorded. SUVmax was measured in all lymph nodes expressing tracer uptake after vaccination. Among 712 PET/CT scans with 2-[¹⁸F]FDG, 104 were submitted to vaccination; 89/104 patients (85%) presented… More >

Muhannad Alsyouf¹, Jonathan Maldonado, Laura Denham², Bonnie Rohweller², Jason Groegler¹, Phillip Stokes¹, Mohammad Hajiha¹, Akin Amasyali¹, Herbert Ruckle¹, Brian Hu¹

Canadian Journal of Urology, Vol.29, No.5, pp. 11312-11317, 2022

Abstract Introduction: Perivesical lymph nodes were added to the 8th edition of American Joint Committee on Cancer (AJCC) staging for bladder cancer. Currently, these nodes are inconsistently evaluated at the time of radical cystectomy. The objective of this study was to provide a detailed anatomic evaluation of perivesical lymph nodes.
Materials and methods: A radical cystectomy was performed on six un-embalmed cadavers with wide resection of perivesical tissue and meticulous care to separate the pelvic sidewall lymph nodes (e.g. obturator, external iliac) from the bladder and perivesical en-bloc specimen. Perivesical tissue dissection in 2 mm slices was performed… More >

Ali Ariafar^1,2,a, Mohammadrasul Zareinejad^3,4,a, Mohammadreza Soltani¹, Yasmin Vahidi³, Zahra Faghih³

European Cytokine Network, Vol.32, No.1, pp. 1-7, 2021, DOI:10.1684/ecn.2021.0462

Abstract Background: Bladder cancer (BC) is the tenth common cancer worldwide. Despite progress in treatment and the use of chemotherapeutic drugs, the survival rate of BC patients is still low. Manipulation of the immune system was recently introduced as an interesting alternative treatment for this immunogenic cancer with fewer side effects. Accordingly, in the present study, we assessed the frequency of GM-CSF-producing lymphocytes in tumor-draining lymph nodes (TDLNs) of BC patients and evaluated their relationship with clinicopathological factors and survival rate. Methods: Fifty-four patients with BC who had received no treatment were recruited. Mononuclear cells were… More >

JOÃO OLIVEIRA PEREIRA^1,2,*, JOÃO GAMA³, DIANA FERREIRA^2,4, ARSÉNIO SANTOS^2,4

Oncology Research, Vol.29, No.2, pp. 81-85, 2021, DOI:10.32604/or.2022.023450 - 13 July 2022

Abstract Hypercalcaemia and leukocytosis are two paraneoplastic conditions associated with poor prognosis. Adenosquamous carcinoma is a rare and aggressive histological subtype of lung cancer consisting of adenocarcinoma and squamous cell components. We report the case of a 57-year-old male smoker who was admitted to the Emergency Room with skull and neck tumefactions, confusion and deteriorated general condition. The complementary study in the ER revealed severe hypercalcaemia (19.8 mg/dL), leukocytosis (18.7 × 10⁹ /L) and extensive osteolytic lesions of the skull on cranioencephalic computer tomography (CT). The patient was stabilized and admitted. Thoracoabdominopelvic CT showed lung parenchyma consolidation More >

Yu Xiao¹, Peng Zhou², Yizi Zheng¹, Chang Zheng¹, Guowen Liu¹, Weixiang Liu^3,*

Oncologie, Vol.23, No.2, pp. 219-228, 2021, DOI:10.32604/Oncologie.2021.016480 - 22 June 2021

Abstract The elevation for lateral lymph node metastasis (LLNM) plays an important role in therapeutic decision-making for thyroid carcinoma. A reliable forecasting model for LLNM in patients with papillary thyroid micro-carcinoma (PTMC) is needed, using clinicopathological characteristics. A total of 576 PTMC patients with suspicious lateral cervical lymph node (II, III, IV or V region) metastasis and known clinicopathological variables were randomly collected at Shenzhen Second People’s Hospital. Cervical lymph node status of every patient was assessed by ultrasonography (US). The patients in this cohort study underwent thyroidectomy and lateral neck lymph node dissection. Univariate analysis… More >

Kassem S. Faraj¹, Haidar M. Abdul-Muhsin¹, Anojan K. Navaratnam¹, Kyle M. Rose¹, Jeffrey Stagg², Thai H. Ho³, Alan H. Bryce³, Scott M. Cheney¹, Mark D. Tyson¹, Erik P. Castle¹

Canadian Journal of Urology, Vol.26, No.3, pp. 9752-9757, 2019

Abstract Introduction: The management of malignant mesothelioma of the tunica vaginalis (MMTVT) is not clearly defined. Retroperitoneal lymph node dissection has been reported as a potential management option. Herein we present our experience with robot-assisted retroperitoneal lymph node dissection (RARPLND) in our series of patients with MMTVT.
Materials and methods: The Mayo Clinic cancer registry was queried from 1972-present for all patients who had a diagnosis of MMTVT. Six patients were identified, five of whom were treated with RPLND, where four underwent RARPLND.
Results: In five patients who underwent RPLND, the median age was 50 years (IQR 34-51). Four… More >