Zixin Wan1,2,#, Jingdan Quan1,2,#, Yue Qiu1,2, Zhiwei Zhang1,2,*
Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.082561
- 16 July 2026
Abstract Gastric cancer (GC) is one of the malignant tumors with high incidence and mortality worldwide. It has concealed early symptoms, poor prognosis for advanced patients, and limited efficacy of conventional treatments. Metabolic reprogramming is a core hallmark of cancer, among which amino acid metabolic reprogramming plays a critical regulatory role in the initiation and progression of GC. By linking intracellular energy supply, biosynthetic demands, and tumor microenvironment remodeling, it participates in immune escape, redox homeostasis maintenance, and therapeutic resistance. Dysregulation of key amino acids, including arginine, tryptophan, glutamine, branched-chain amino acids, serine/glycine, and aspartic acid,… More >