Mariana Lopes^1,#, Carlos Vila Nova^2,3,#, Rui Caetano Oliveira^3,4, Fernando Schmitt⁵, Fernando Mendes^1,6,7,8,9,*, Diana Martins^1,6,7,8

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.074215 - 21 May 2026

Abstract Objectives: Triple-negative breast cancer (TNBC) accounts for approximately 15% of all invasive breast cancers and is characterized by aggressive behavior, limited therapeutic options, and poor clinical outcomes. Due to the absence of hormone receptors and HER2 expression, systemic treatment relies predominantly on chemotherapy, which is associated with high rates of early recurrence and mortality. Emerging evidence suggests that alterations in the microbiome can contribute to TNBC progression and influence therapeutic response, particularly affecting the efficacy of chemotherapy and immunotherapy through immune-mediated mechanisms; however, its role in TNBC remains incompletely understood. This systematic review aims to explore… More >

Nevena Todorovic^1,#, Sara Bertorello^1,#, Giulia Nannini¹, Serena Pillozzi², Simonetta Bianchi³, Maria Raffaella Ambrosio⁴, Elena Niccolai¹, Simone Baldi¹, Amedeo Amedei^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076380 - 22 April 2026

Abstract Background: Cancer remains one of the leading global health challenges, with lung cancer (LC), breast cancer (BC), and colorectal cancer (CRC) among the most prevalent and deadly malignancies. The intratumoral microbiota (IM), a distinct microbial ecosystem within tumor tissues, has recently emerged as a potential modulator of carcinogenesis, immune responses, and metastatic progression. However, comparative cross-cancer analyses remain limited. Therefore, this study aimed to compare the IM across these cancer types, with particular emphasis on distinguishing metastatic from non-metastatic malignancies, to identify tumor-specific microbial signatures with potential relevance for biomarker discovery, patient stratification, and microbiota-informed… More >

Shuyu Yuan^1,#, Guoxiao Han^1,#, Huimin Qiu¹, Henan Zheng², Rongzhi Fang¹, Wangmiao Xie¹, Wangui Yu^1,*, Xiaochun Peng^1,*

BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2026.075338 - 21 April 2026

Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis. Accumulating evidence has demonstrated that dysbiosis of the gut microbiota is closely associated with metabolic disorders, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). These alterations affect energy harvest, bile acid and short-chain fatty acid metabolism, intestinal barrier integrity, and low-grade inflammation, thereby contributing to insulin resistance and ectopic fat accumulation. In this narrative review, we summarize current knowledge on microbiome-host interactions in metabolic diseases, with a focus on energy metabolism, immune regulation, and inflammatory pathways. We further More > Graphic Abstract

Xiaofeng Mao^1,#, Fenni Lv^1,2,#, Shaofeng Li³, Lulu Gao^1,2, Wenjun Ma⁴, Donglai Liu¹, Binpeng Wu¹, Yanan Wu¹, Peng Wang^1,2,*, Naiwei Li^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.2, 2026, DOI:10.32604/phyton.2026.072636 - 28 February 2026

Abstract Catalpa bungei, a fast-growing timber tree, is threatened by the lepidopteran pest Omphisa plagialis. Previous studies in our laboratory successfully generated transgenic C. bungei lines overexpressing Cry genes (Cry1Ab, Cry2A, and Cry9-2) that exhibited resistance to O. plagialis, but their potential impact on soil bacterial communities remains unclear. In this study, we analyzed nine transgenic C. bungei lines (three independent lines for each Cry gene) to characterize their rhizosphere bacterial communities using high-throughput sequencing of the 16S ribosomal DNA (rDNA) V4–V5 regions. A total of 628 amplicon sequence variants (ASVs) were shared among all transgenic and wild-type (WT) lines, forming a stable core… More >

Fangyuan Zhang^1,#, Xi Wang^2,#, Xinxin Shen³, Pei Xiong³, Yan Yang^4,*, Jincheng Wang^5,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.074893 - 24 February 2026

Abstract Accumulating evidence indicates that the neuro-immune axis is central to gastric cancer pathogenesis. Dynamic, bidirectional signaling between neural circuits and immune cells promotes tumor progression, shapes an immunosuppressive microenvironment, and contributes to therapeutic resistance. We synthesize current knowledge on how autonomic (sympathetic and parasympathetic) and sensory innervation regulate gastric cancer biology. These circuits act through neurotransmitters (catecholamines, acetylcholine) and neuropeptides (substance P [SP], calcitonin gene-related peptide [CGRP]) to foster tumor growth and angiogenesis, facilitate perineural invasion, and enable immune evasion by recruiting suppressive myeloid and lymphoid populations and by inducing checkpoint molecule expression. We also… More >

Hong Chen^1,2, Runze Yang^1,2, Jing Tian^1,2, Boyuan Xu^1,2, Qiang Chen³, Yuzong Chen^1,2, Ming-Xiao Zhao^1,2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2025.072276 - 30 January 2026

Abstract Panax species are globally recognized for their high medicinal and economic value, yet large-scale cultivation is constrained by high production costs, progressive soil acidification, and persistent soil-borne diseases. Although various soil improvement strategies have been tested, a comprehensive synthesis of their comparative effectiveness has been lacking. Here, we conducted a meta-analysis of 1381 observations from 54 independent studies to evaluate the effects of conventional fertilizers, microbial fertilizers, organic amendments, and inorganic amendments on Panax cultivation. Our results demonstrate that microbial fertilizers, organic amendments, and inorganic amendments significantly increased soil pH, thereby ameliorating soil acidification. Among them,… More >

Jiunn-Wei Wang^1,2,3, Wen-Hung Hsu^2,3,4, Fang-Jung Yu^2,3, Fu-Chen Kuo⁵, Chung-Jung Liu^3,6, Chao-Hung Kuo^1,2,3, Jaw-Yuan Wang^7,8, Ming-Hong Lin^9,*, Deng-Chyang Wu^1,2,3,*

Oncology Research, Vol.33, No.12, pp. 3907-3922, 2025, DOI:10.32604/or.2025.070432 - 27 November 2025

Abstract Objectives: Colorectal adenomatous polyps frequently recur after removal and are precursors to colorectal cancer, highlighting the need for effective preventive strategies. This study evaluated the efficacy of probiotic Clostridium butyricum MIYAIRI 588 (CBM588) in preventing colorectal adenoma recurrence in high-risk patients. Methods: We conducted a randomized, single-blind, two-year crossover trial in patients with a history of adenomatous polyps. Participants received CBM588 in either the first or second year, with the alternate year as observation, and underwent annual surveillance colonoscopies. Outcomes (adenoma recurrence and polyp counts) were analyzed by intention-to-treat (ITT) and per-protocol (PP) approaches. Results: A total… More >

Anastasia Vylegzhanina^1,2, Irina Shalaginova^2,*, Dana Korolevich¹, Dmitry Katserov¹, Alexandra Semenova¹, Maria Sidorova¹, Sergey Eresko³, Marat Airapetov³, Marina Pavlova², Anna Levina², Natalia Dyuzhikova²

BIOCELL, Vol.49, No.10, pp. 2007-2031, 2025, DOI:10.32604/biocell.2025.071198 - 22 October 2025

Abstract Objectives: Chronic stress can trigger neuroinflammation and gut microbiota alterations, contributing to post-stress disorders. Individual differences in stress responses, shaped by genetic and physiological factors, require better characterization. We aimed to investigate the long-term effects of chronic stress in rats selectively bred for high and low nervous system excitability. Methods: Adult male rats from two strains selectively bred for high (HT) and low (LT) excitability thresholds of the nervous system underwent a 15-day chronic emotional-pain stress protocol. Behavioral assessments (elevated plus maze), cytokine levels (TNF, IL-1β, IL-6, IL-10) in the hippocampus and amygdala measured by… More >

Stephanie Seneff^1,*, Greg Nigh², Anthony M. Kyriakopoulos^3,4

BIOCELL, Vol.49, No.9, pp. 1545-1572, 2025, DOI:10.32604/biocell.2025.066687 - 25 September 2025

Abstract Deuterium is a heavy isotope of hydrogen, with an extra neutron, endowing it with unique biophysical and biochemical properties compared to hydrogen. The ATPase pumps in the mitochondria depend upon proton motive force to catalyze the reaction that produces ATP. Deuterons disrupt the pumps, inducing excessive reactive oxygen species and decreased ATP synthesis. The aim of this review is to develop a theory that mitochondrial dysfunction due to deuterium overload, systemically, is a primary cause of Parkinson’s disease (PD). The gut microbes supply deuterium-depleted short chain fatty acids (SCFAs) to the colonocytes, particularly butyrate, and… More >

Akari Fukumoto, Satoru Matsuda^*

Oncology Research, Vol.33, No.9, pp. 2205-2219, 2025, DOI:10.32604/or.2025.062810 - 28 August 2025

Abstract The non-coding RNAs (ncRNAs) are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology. The gut microbiota, which consists of several different bacteria, can actively contribute to the regulation of host metabolism, immunity, and inflammation. Roles of ncRNAs and gut microbiota could significantly interact with each other to regulate the growth of various types of cancer. In particular, a causal relationship among ncRNAs, gut microbiota, and immune cells has been shown for their potential importance in the development of breast cancer. Alteration of ncRNA More >