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Search Results (22)
  • Open Access

    ARTICLE

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

    HUI SUN, MASANORI KAWANO*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

    Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085

    Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in… More > Graphic Abstract

    MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

  • Open Access

    ARTICLE

    The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

    MASANORI KAWANO, KAZUHIRO TANAKA*, ICHIRO ITONAGA, TATSUYA IWASAKI, YUTA KUBOTA, HIROSHI TSUMURA

    Oncology Research, Vol.31, No.5, pp. 631-643, 2023, DOI:10.32604/or.2023.029745

    Abstract Heat shock protein (HSP) 90 plays a crucial role in correcting the misfolded three-dimensional structure of proteins, assisting them in folding into proper conformations. HSP90 is critical in maintaining the normal functions of various proteins within cells, as essential factors for cellular homeostasis. Contrastingly, HSP90 simultaneously supports the maturation of cancer-related proteins, including mesenchymal epithelial transition factor (MET) within tumor cells. All osteosarcoma cell lines had elevated MET expression in the cDNA array in our possession. MET, a tyrosine kinase receptor, promotes proliferation and an anti-apoptotic state through the activation of the MET pathway constructed by HSP90. In this study,… More > Graphic Abstract

    The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

  • Open Access

    ARTICLE

    Symbiotic Organisms Search with Deep Learning Driven Biomedical Osteosarcoma Detection and Classification

    Abdullah M. Basahel1, Mohammad Yamin1, Sulafah M. Basahel2, Mona M. Abusurrah3, K.Vijaya Kumar4, E. Laxmi Lydia5,*

    CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 133-148, 2023, DOI:10.32604/cmc.2023.031786

    Abstract Osteosarcoma is one of the rare bone cancers that affect the individuals aged between 10 and 30 and it incurs high death rate. Early diagnosis of osteosarcoma is essential to improve the survivability rate and treatment protocols. Traditional physical examination procedure is not only a time-consuming process, but it also primarily relies upon the expert’s knowledge. In this background, the recently developed Deep Learning (DL) models can be applied to perform decision making. At the same time, hyperparameter optimization of DL models also plays an important role in influencing overall classification performance. The current study introduces a novel Symbiotic Organisms… More >

  • Open Access

    ARTICLE

    Expression and Clinical Significance of ACTA2 in Osteosarcoma Tissue

    Lina Tang1,2, Haiyan Hu2, Yan Zhou2, Yujing Huang2, Yonggang Wang2, Yawen Zhang2, Jinrong Liang2, Zhenxin Wang1,*

    Oncologie, Vol.24, No.4, pp. 913-925, 2022, DOI:10.32604/oncologie.2022.026296

    Abstract Objective: To investigate the expression of alpha–smooth muscle actin (ACTA2) in osteosarcoma tissues and its relationship with prognosis. Methods: Prognostic analysis of lung metastasis–related genes in osteosarcoma using the TCGA database. Single-cell sequencing detected the expression of ACTA2 in 11 osteosarcoma tissues. Paraf- fin-embedded tissues of 74 osteosarcoma patients treated at the Sixth People’s Hospital of Shanghai Jiao Tong University from 2014 to 2019 were collected, and tissue microarrays were prepared. ACTA2 expression was detected and scored by immunohistochemistry. According to the median value of the ACTA2 histochemical score, 74 patients were divided into two groups, the high-expression group and… More >

  • Open Access

    ARTICLE

    Investigation of the Nd-Ce-Mg-Zn/Substituted Hydroxyapatite Effect on Biological Properties and Osteosarcoma Cells

    Suha Q. AL-Shahrabalee*, Hussein Alaa Jaber

    Journal of Renewable Materials, Vol.11, No.3, pp. 1485-1498, 2023, DOI:10.32604/jrm.2023.025011

    Abstract Cancerous diseases and diseases resulting from bacteria and fungi are some of the pressures that humans face. Therefore, the development of biomaterials that are resistant to cancerous diseases, bacteria, and fungi has become one of the requirements of the medical field to extend the life of the biomaterial and fight pathogens after implanting these materials inside the human body. One of the important biomaterials used in the field of orthopedics is hydroxyapatite. In this research, Nano substituted hydroxyapatite was prepared by the wet precipitation method, including replacing 5% of the calcium ions with neodymium, cerium, magnesium, and zinc ions in… More > Graphic Abstract

    Investigation of the Nd-Ce-Mg-Zn/Substituted Hydroxyapatite Effect on Biological Properties and Osteosarcoma Cells

  • Open Access

    ARTICLE

    Biomedical Osteosarcoma Image Classification Using Elephant Herd Optimization and Deep Learning

    Areej A. Malibari1, Jaber S. Alzahrani2, Marwa Obayya3, Noha Negm4,5, Mohammed Abdullah Al-Hagery6, Ahmed S. Salama7, Anwer Mustafa Hilal8,*

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 6443-6459, 2022, DOI:10.32604/cmc.2022.031324

    Abstract Osteosarcoma is a type of malignant bone tumor that is reported across the globe. Recent advancements in Machine Learning (ML) and Deep Learning (DL) models enable the detection and classification of malignancies in biomedical images. In this regard, the current study introduces a new Biomedical Osteosarcoma Image Classification using Elephant Herd Optimization and Deep Transfer Learning (BOIC-EHODTL) model. The presented BOIC-EHODTL model examines the biomedical images to diagnose distinct kinds of osteosarcoma. At the initial stage, Gabor Filter (GF) is applied as a pre-processing technique to get rid of the noise from images. In addition, Adam optimizer with MixNet model… More >

  • Open Access

    ARTICLE

    Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

    Bo Xia*, Lei Wang, Li Feng*, Baofang Tian*, Yuanjie Tan, Baoyin Du*

    Oncology Research, Vol.27, No.1, pp. 89-98, 2019, DOI:10.3727/096504018X15199511344806

    Abstract Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. This study aimed to explore the effects of long noncoding RNA CAT104 and microRNA-381 (miR-381) on osteosarcoma cell proliferation, migration, invasion, and apoptosis, as well as the underlying potential mechanism. We found that CAT104 was highly expressed in osteosarcoma MG63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration, and invasion, but promoted cell apoptosis. CAT104 regulated the expression of miR-381, and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc finger E-box-binding homeobox 1 (ZEB1) was a direct target gene of… More >

  • Open Access

    ARTICLE

    Knockdown of Urothelial Carcinoma-Associated 1 Suppressed Cell Growth and Migration Through Regulating miR-301a and CXCR4 in Osteosarcoma MHCC97 Cells

    Genglong Zhu*, Xialei Liu*, Yonghui Su, Fangen Kong, Xiaopeng Hong*, Zhidong Lin

    Oncology Research, Vol.27, No.1, pp. 55-64, 2019, DOI:10.3727/096504018X15201143705855

    Abstract Liver cancer is one of the most common malignancies in the world and a leading cause of cancer-related mortality. Accumulating evidence has highlighted the critical role of long noncoding RNAs (lncRNAs) in various cancers. The present study aimed to explore the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in cell growth and migration in MHCC97 cells and its underlying mechanism. First, we assessed the expression of UCA1 in MHCC97 and three other cell lines by RT-qPCR. Then the expression of UCA1, miR-301a, and CXCR4 in MHCC97 cells was altered by transient transfection. The effects of UCA1 and miR-301 on cell… More >

  • Open Access

    ARTICLE

    Thrombospondin 1 Triggers Osteosarcoma Cell Metastasis and Tumor Angiogenesis

    Yue Kui Jian1, Huan Ye Zhu1, Xing Lin Wu, Bo Li

    Oncology Research, Vol.27, No.2, pp. 211-218, 2019, DOI:10.3727/096504018X15208993118389

    Abstract Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumor effects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here we demonstrated that thrombospondin 1 (TSP-1) is a potent inhibitor of the growth and metastasis of the osteosarcoma cell line MG-63. Moreover, we demonstrate that upregulation of TSP-1 facilitated expression of vasculostatin in MG-63 cells. In angiogenesis assays, overexpression of TSP-1 inhibited MG-63 cells and induced tube formation of human umbilical vein endothelial cells (HUVECs) in a CD36-dependent fashion.… More >

  • Open Access

    ARTICLE

    miR-363-3p Inhibits Osteosarcoma Cell Proliferation and Invasion via Targeting SOX4

    Kejun Wang*1, Lin Yan*1, Fen Lu

    Oncology Research, Vol.27, No.2, pp. 157-163, 2019, DOI:10.3727/096504018X15190861873459

    Abstract miR-363-3p has been shown to suppress tumor growth and metastasis in various human cancers. However, the function of miR-363-3p in osteosarcoma (OS) has not been determined. In our study, we found that the expression of miR-363-3p was significantly downregulated in OS tissues compared with adjacent normal tissues. miR-363-3p expression was associated with the poor overall survival rate of OS patients. Moreover, we found that overexpression of miR-363-3p markedly inhibited the proliferation, migration, and invasion of U2OS and MG63 cells. Moreover, we found that SOX4 was a direct target of miR-363-3p in OS cells. Overexpression of miR-363-3p significantly inhibited the expression… More >

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