Pasquale De Luca^1,2,*, Livia Marcellino¹

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.082664 - 30 June 2026

Abstract Osteosarcoma is the most common primary malignant bone tumor in pediatric populations. This work presents an extended Physics-Informed Neural Network framework that incorporates interferon-gamma (IFN-γ) as a fifth biological variable, complementing previous four-variable formulations with an explicit cytokine-mediated macrophage activation pathway. The model couples five biological fields with mechanical tissue response through Biot’s poroelastic theory over a two-dimensional domain. Four distinct initial macrophage distributions were investigated. Numerical stability was achieved across all scenarios, with total loss values between 0.056 and 0.158 and mechanical residuals below 3.2×10−5. The boundary-concentrated configuration yielded the lowest biological loss. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.086719 - 16 June 2026

Abstract This article has no abstract. More >

Rebecca H. Maggs^*, Marcus J. Brookes, Kenneth S. Rankin

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069781 - 19 January 2026

Abstract Background: Photodynamic therapy (PDT) may eradicate residual malignant cells following sarcoma resection, through reactive oxygen species (ROS) mediated cytotoxicity, thus improve clinical outcomes. This study aims to assess the efficacy of 5-aminolevulinic acid (5-ALA) as a photosensitizer in combination with red light (RL) for PDT of bone sarcoma cells in vitro. Methods: Three bone sarcoma cell lines underwent treatment with 5-ALA and RL or sham-RL (SL). 5-ALA uptake was assessed using flow cytometry. Production of ROS was measured using CellROX Green staining and fluorescence microscopy. Cell viability was assessed using Cell Counting Kit-8 assays. Results: All cell… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077270 - 30 December 2025

Abstract This article has no abstract. More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.12, pp. 4155-4155, 2025, DOI:10.32604/or.2025.075990 - 27 November 2025

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.11, pp. 3607-3607, 2025, DOI:10.32604/or.2025.074403 - 22 October 2025

Abstract This article has no abstract. More >

LICHEN XU^1,2, PAN ZHANG³, GUIQI ZHANG², ZHAOLIANG SHEN⁴, XIZHUANG BAI^1,3,*

Oncology Research, Vol.33, No.7, pp. 1797-1798, 2025, DOI:10.32604/or.2024.061279 - 26 June 2025

Abstract This article has no abstract. More >

LIWEN FENG^1,2,#,*, YUTING CHEN^3,#, WENYI JIN⁴

Oncology Research, Vol.33, No.5, pp. 1091-1103, 2025, DOI:10.32604/or.2024.054207 - 18 April 2025

Abstract Osteosarcoma (OS) is a prevalent primary bone malignancy with limited treatment options. Therefore, it is imperative to investigate and understand the mechanisms underlying OS pathogenesis. Cancer-associated fibroblasts (CAFs) are markedly abundant in tumor stromal cells and are essentially involved in the modulation of tumor occurrence and development. In recent years, CAFs have become a hotspot as researchers aim to elucidate CAF mechanisms that regulate tumor progression. However, most studies on CAFs are limited to a few common cancers, and their association with OS remains elusive. This review describes the role and current knowledge of CAFs More >

HYE IN KA^#, SE HWAN MUN^#, SORA HAN^#, YOUNG YANG^*

Oncology Research, Vol.33, No.3, pp. 519-531, 2025, DOI:10.32604/or.2024.056860 - 28 February 2025

Abstract Osteosarcoma is a bone malignancy characterized by strong invasiveness and rapid disease progression. The tumor microenvironment of osteosarcoma contains various types of immune cells, including myeloid-derived suppressor cells, macrophages, T cells, and B cells. Imbalances of these immune cells can promote the proliferation and metastasis of osteosarcoma. Recent studies have indicated a substantial increase in the levels of myeloid-derived suppressor cells, an immune cell associated with immunosuppressive and pro-cancer effects, in the peripheral blood of patients with osteosarcoma. Moreover, the levels of the pro-inflammatory cytokine interleukin 18 are positively correlated with those of myeloid-derived suppressor More >