NILAM BHUSARE, MAUSHMI KUMAR^*

Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

JINGJING CHEN¹, DAN WANG², ZEQUN WANG², MENGYUAN HAN⁴, HOUQING YIN², WENTING ZHOU⁴, RIBAI YAN⁵, YAN PAN^2,3,*

Oncology Research, Vol.32, No.5, pp. 911-923, 2024, DOI:10.32604/or.2023.042384

Abstract Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901… More > Graphic Abstract

Chengzhang Zhu^1,2, Renmao Zhang¹, Yalong Xiao^1,2,*, Beiji Zou¹, Xian Chai¹, Zhangzheng Yang¹, Rong Hu³, Xuanchu Duan⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1103-1128, 2024, DOI:10.32604/cmes.2024.048453

Abstract Automatic segmentation of medical images provides a reliable scientific basis for disease diagnosis and analysis. Notably, most existing methods that combine the strengths of convolutional neural networks (CNNs) and Transformers have made significant progress. However, there are some limitations in the current integration of CNN and Transformer technology in two key aspects. Firstly, most methods either overlook or fail to fully incorporate the complementary nature between local and global features. Secondly, the significance of integrating the multi-scale encoder features from the dual-branch network to enhance the decoding features is often disregarded in methods that combine CNN and Transformer. To address… More >

Zhong Qu^1,*, Guoqing Mu¹, Bin Yuan²

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 255-273, 2024, DOI:10.32604/cmes.2024.048175

Abstract Automatic crack detection of cement pavement chiefly benefits from the rapid development of deep learning, with convolutional neural networks (CNN) playing an important role in this field. However, as the performance of crack detection in cement pavement improves, the depth and width of the network structure are significantly increased, which necessitates more computing power and storage space. This limitation hampers the practical implementation of crack detection models on various platforms, particularly portable devices like small mobile devices. To solve these problems, we propose a dual-encoder-based network architecture that focuses on extracting more comprehensive fracture feature information and combines cross-fusion modules… More > Graphic Abstract

Zun-Di Huang¹, Zhen-Bin Zhou^1,2,3, Ning Chang¹, Zheng-Wei Chen^2,3,*, Su-Mei Wang^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 975-996, 2024, DOI:10.32604/cmes.2024.047664

Abstract The safety and stability of high-speed maglev trains traveling on viaducts in crosswinds critically depend on their aerodynamic characteristics. Therefore, this paper uses an improved delayed detached eddy simulation (IDDES) method to investigate the aerodynamic features of high-speed maglev trains with different marshaling lengths under crosswinds. The effects of marshaling lengths (varying from 3-car to 8-car groups) on the train’s aerodynamic performance, surface pressure, and the flow field surrounding the train were investigated using the three-dimensional unsteady compressible Navier-Stokes (N-S) equations. The results showed that the marshaling lengths had minimal influence on the aerodynamic performance of the head and middle… More > Graphic Abstract

Wenxiang Dong, H. Vicky Zhao^*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 139-170, 2024, DOI:10.32604/cmes.2024.047156

Abstract Understanding and modeling individuals’ behaviors during epidemics is crucial for effective epidemic control. However, existing research ignores the impact of users’ irrationality on decision-making in the epidemic. Meanwhile, existing disease control methods often assume users’ full compliance with measures like mandatory isolation, which does not align with the actual situation. To address these issues, this paper proposes a prospect theory-based framework to model users’ decision-making process in epidemics and analyzes how irrationality affects individuals’ behaviors and epidemic dynamics. According to the analysis results, irrationality tends to prompt conservative behaviors when the infection risk is low but encourages risk-seeking behaviors when… More >

Zhuo Huang, Ye Tian, Yifan Zhang, Tielin Shi, Qi Xia^*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 711-733, 2024, DOI:10.32604/cmes.2024.045411

Abstract Stiffened structures have great potential for improving mechanical performance, and the study of their stability is of great interest. In this paper, the optimization of the critical buckling load factor for curved grid stiffeners is solved by using the level set based density method, where the shape and cross section (including thickness and width) of the stiffeners can be optimized simultaneously. The grid stiffeners are a combination of many single stiffeners which are projected by the corresponding level set functions. The thickness and width of each stiffener are designed to be independent variables in the projection applied to each level… More >

SAIFEI XIE^1,2,4, HUI XIE^2,*, JINCAI GUO³, JIN TAN⁴, YULIN YU¹, MINYI ZHANG¹, SHANG WEN¹

BIOCELL, Vol.48, No.4, pp. 591-599, 2024, DOI:10.32604/biocell.2024.046691

Abstract Background: Puerarin (Pue) has been reported to be a natural active ingredient with multiple antifibrotic properties. This work aimed at exploring the function of Pue in oral submucous fibrosis (OSF) treatment. Methods: Human oral mucosa fibroblasts (hOMF) were induced with transforming growth factor beta1 (TGF-β1) and intervened with Pue. Expressions of fibrosis-related markers were analyzed by Western blot and IF staining. Cell viability was characterized by the CCK-8 assay. Expressions of miR-30 family members were quantified by qRT-PCR. The correlation between fibroblast activation protein (FAP) and miR-30 family expression was evaluated by the Pearson correlation coefficient. Bioinformatics prediction and dual-luciferase… More > Graphic Abstract

Liting Jia¹, Xiao Han¹, Cuixia Qiao², Gang Zhao², Yanzhi Xia¹, Zhixin Xue^1,*

Journal of Renewable Materials, Vol.12, No.3, pp. 427-441, 2024, DOI:10.32604/jrm.2023.044310

Abstract Ba²⁺ pre-crosslinked carrageenan fiber (Ba/CAF) was prepared by adding a small amount of Ba²⁺ to the carrageenan (CA) solution as the spinning solution. Ba/CAF-n/A, Ba/CAF-n/B and Ba/CAF-n/C were prepared with ethanol solution (combine A), high concentration BaCl₂ solution (combine B) and low concentration BaCl₂ solution (combine C), as coagulation bath and stretch bath, respectively. The combination of coagulation bath and stretch bath suitable for Ba²⁺ pre-crosslinking wet spinning was screened. The results showed that Ba²⁺ can induce the birefringence of the CA molecular chain, and the Ba²⁺ pre-crosslinking effect is the best when the CA mass fraction is 8.0 wt%.… More > Graphic Abstract

Feng Sheng^1,*, Chen Kong², Chao Li³

International Journal of Mental Health Promotion, Vol.26, No.3, pp. 221-228, 2024, DOI:10.32604/ijmhp.2024.030209

Abstract Objective: This study was conducted to explore the relationships among sedentary behavior (SB), electronic product addiction (EPA), and depression (D) in adolescents during the COVID-19 epidemic. Methods: A total of 604 adolescents (including 309 girls and 295 boys aged 12–18) were selected from Qufu City, Shandong Province, China for three rounds of investigation. The model was constructed using AMOS 23.0 software, and cross-lagged analysis was conducted. Results: SB at T1 can significantly positively predict SB and EPA at T2 (p < 0.05). EPA at T1 can significantly positively predict SB and D at T2 (p < 0.05). Physical activity level… More >