JIANBO ZHOU^1,2,3, FENG WAN^2,4, BIN XIAO⁵, XIN LI¹, CHENG PENG^2,*, FU PENG^1,3,*

Oncology Research, Vol.32, No.5, pp. 943-953, 2024, DOI:10.32604/or.2023.044775

Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro, and reduced tumor growth in vivo. Moreover, transcriptomic analysis revealed that TEC modulated the activity… More > Graphic Abstract

T. Aghalya, R. Tamizharasi^*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 431-460, 2024, DOI:10.32604/cmes.2024.046635

Abstract In this study, the characteristics of heat transfer on an unsteady magnetohydrodynamic (MHD) Casson nanofluid over an exponentially accelerated vertical porous plate with rotating effects were investigated. The flow was driven by the combined effects of the magnetic field, heat radiation, heat source/sink and chemical reaction. Copper oxide () and titanium oxide () are acknowledged as nanoparticle materials. The nondimensional governing equations were subjected to the Laplace transformation technique to derive closed-form solutions. Graphical representations are provided to analyze how changes in physical parameters, such as the magnetic field, heat radiation, heat source/sink and chemical reaction, affect the velocity, temperature… More >

LIJUAN ZHANG^1,#, QINGYIN MENG^2,#, LI ZHUANG¹, QUAN GONG¹, XIANDA HUANG³, XUEQIN LI¹, SHIJUAN LI¹, GUOQIN WANG⁴, XICAI WANG^5,*

BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260

Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells. Furthermore, we examined tumorigenesis and… More > Graphic Abstract

NEETU TRIPATHI, DIBYENDU S. BAG^*, MAYANK DWIVEDI

Journal of Polymer Materials, Vol.40, No.3-4, pp. 227-269, 2023, DOI:10.32381/JPM.2023.40.3-4.8

Abstract Over the last three decades, there has been considerable interest in the captivating mechanical properties displayed by auxetic materials, highlighting the advantages stemming from their distinct negative Poisson's ratio. The negative Poisson's ratio observed in auxetic polymeric materials is a result of the distinctive geometries of their unit cells. These unit cells, encompassing structures such as chiral, re-entrant, and rotating rigid configurations, are carefully engineered to collectively generate the desired auxetic behaviour. This comprehensive review article explores the field of auxetic polymeric materials, offering a detailed exploration of their geometries, fabrication methods, mechanical properties, and characterisation. The diverse applications of… More >

S. H. Elhag^*

Frontiers in Heat and Mass Transfer, Vol.22, No.1, pp. 377-395, 2024, DOI:10.32604/fhmt.2023.044428

Abstract A review of the literature revealed that nanofluids are more effective in transferring heat than conventional fluids. Since there are significant gaps in the illumination of existing methods for enhancing heat transmission in nanomaterials, a thorough investigation of the previously outlined models is essential. The goal of the ongoing study is to determine whether the microscopic gold particles that are involved in mass and heat transmission drift in freely. The current study examines heat and mass transfer on 3D MHD Darcy–Forchheimer flow of Casson nanofluid-induced bio-convection past a stretched sheet. The inclusion of the nanoparticles is a result of their… More >

Yamixa Delgado^1,*, Caliani Gaytan¹, Naydi Perez², Eric Miranda³, Bryan Colón Morales¹, Mónica Santos¹

Congenital Heart Disease, Vol.19, No.1, pp. 19-31, 2024, DOI:10.32604/chd.2024.046339

Abstract Background: Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among body mass index (BMI), pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development. Methods: Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI, pregestational diabetes, gestational diabetes, hypertension,… More >

LU ZHANG^*, JINGUO CHU^*, YUSHAN YU

Oncology Research, Vol.32, No.4, pp. 703-716, 2024, DOI:10.32604/or.2023.030988

Abstract Background: Limited research has been conducted on the influence of autophagy-associated long non-coding RNAs (ARLncRNAs) on the prognosis of hepatocellular carcinoma (HCC). Methods: We analyzed 371 HCC samples from TCGA, identifying expression networks of ARLncRNAs using autophagy-related genes. Screening for prognostically relevant ARLncRNAs involved univariate Cox regression, Lasso regression, and multivariate Cox regression. A Nomogram was further employed to assess the reliability of Riskscore, calculated from the signatures of screened ARLncRNAs, in predicting outcomes. Additionally, we compared drug sensitivities in patient groups with differing risk levels and investigated potential biological pathways through enrichment analysis, using consensus clustering to identify subgroups… More >

Morteza Eslamian^*

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-20, 2011, DOI:10.5098/hmt.v2.4.3001

Abstract Recent advances in thermodiffusion (Soret effect) in binary and higher multicomponent liquid mixtures are reviewed. The mixtures studied include the hydrocarbon, associating, molten metal and semiconductor, polymer, and DNA mixtures. The emphasis is placed on the theoretical works, particularly models based on the nonequilibrium thermodynamics, although other approaches such as the statistical, kinetic and hydrodynamic approaches are discussed as well. For each mixture, the major theoretical and experimental works are discussed and the research trends and challenges are addressed. Some of the challenges include a need for combining various methods to develop a comprehensive theoretical model or at least to… More >

Frontiers in Heat and Mass Transfer, Vol.2, No.2, pp. 1-1, 2011, DOI:10.5098/hmt.v2.2.1001

Abstract This article has no abstract. More >

HAO LV¹, BO ZHU^1,2, DEGAO CHEN^1,2,*

BIOCELL, Vol.48, No.3, pp. 363-378, 2024, DOI:10.32604/biocell.2023.046367

Abstract Tumor-associated macrophages (TAMs) are emerging as targets for tumor therapy because of their primary role in promoting tumor progression. Several studies have been conducted to target TAMs by reducing their infiltration, depleting their numbers, and reversing their phenotypes to suppress tumor progression, leading to the development of drugs in preclinical and clinical trials. However, the heterogeneous characteristics of TAMs, including their ontogenetic and functional heterogeneity, limit their targeting. Therefore, in-depth exploration of the heterogeneity of TAMs, combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment. This review focuses on the heterogeneous ontogeny and… More >