YUNZE XUAN1,#, BIN JIN1,#, SAYAN DEB DUTTA5,#, MENGMENG LIU2, ZAIXIAN SHEN1, XIWEN LIU3, YANG KANGJUAN4,*, LIM KI-TAEK5,*
BIOCELL, Vol.44, No.3, pp. 389-400, 2020, DOI:10.32604/biocell.2020.09170
Abstract Periodontitis is a type of chronic inflammation in the gingival tissue caused by infectious bacteria colonizing the
surface of the teeth, leading to the destruction of tooth-supporting tissues and loss of alveolar bone. Suberoylanilide
hydroxamic acid (SAHA), a class of histone deacetylase (HDAC) inhibitor, has the potential to stimulate osteoblast
differentiation by acetylating histone proteins, and thus suppressing the expression of adipogenic and chondrogenic
genes. However, the effect of SAHA on the differentiation of human periodontal ligament stem cells (hPDLSCs) is yet
to be elucidated. Herein, we investigated the effects of SAHA on in vitro proliferation and differentiation of hPDLSCs… More >
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