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  • Open Access

    REVIEW

    A review of the literature on the use of CRISPR/Cas9 gene therapy to treat hepatocellular carcinoma

    ELHAM AMJAD1, RAFFAELE PEZZANI2,3,*, BABAK SOKOUTI1,*

    Oncology Research, Vol.32, No.3, pp. 439-461, 2024, DOI:10.32604/or.2023.044473

    Abstract Noncoding RNAs instruct the Cas9 nuclease to site-specifically cleave DNA in the CRISPR/Cas9 system. Despite the high incidence of hepatocellular carcinoma (HCC), the patient’s outcome is poor. As a result of the emergence of therapeutic resistance in HCC patients, clinicians have faced difficulties in treating such tumor. In addition, CRISPR/Cas9 screens were used to identify genes that improve the clinical response of HCC patients. It is the objective of this article to summarize the current understanding of the use of the CRISPR/Cas9 system for the treatment of cancer, with a particular emphasis on HCC as part of the current state… More >

  • Open Access

    ARTICLE

    Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis

    YANG ZHANG1,2,#, NANNAN QIN5,#, XIJUN WANG6,#, RUI LIANG7, QUAN LIU4, RUOYI GENG8, TIANXIAO JIANG8, YUNFEI LIU8,*, JINWEI LI3,4,*

    Oncology Research, Vol.32, No.3, pp. 563-576, 2024, DOI:10.32604/or.2023.029697

    Abstract Glycogen metabolism plays a key role in the development of hepatocellular carcinoma (HCC), but the function of glycogen metabolism genes in the tumor microenvironment (TME) is still to be elucidated. Single-cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells, and 65 glycogen metabolism genes were analyzed by a nonnegative matrix factorization (NMF). The prognosis and immune response of new glycogen TME cell clusters were predicted by using HCC and immunotherapy cohorts from public databases. HCC single-cell analysis was divided into fibroblasts, NT T cells, macrophages, endothelial cells, and B cells, which were separately divided into new… More >

  • Open Access

    ARTICLE

    Psychological Anxiety Intervention for Young Audiences: Effectiveness Evaluation of Art Museums

    Jingjing Zhou1, Yungneng Lin2,*, Tingting Huang1

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 39-49, 2024, DOI:10.32604/ijmhp.2023.045203

    Abstract The mental health of young people, a significant public health concern worldwide, has deteriorated during the COVID-19 pandemic. Despite the subsiding of the epidemic, the issue remains unresolved in the post-pandemic era, specifically in China. In response, numerous art museums have stepped up to provide long-term therapeutic experiences and comprehensive mental health support. While these institutions offer a variety of services and programs aimed at enhancing the psychological well-being of their visitors, a standardized method for assessing their impact is lacking. This study, therefore, employed the Generic Wellbeing Questionnaire (GWQ) as a tool to evaluate the decrease in psychological anxiety… More >

  • Open Access

    ARTICLE

    A Clinical Study on the Effect of Group Nostalgia Therapy on Quality of Life and Cognitive Function in Elderly Patients with Depression

    Yan Huang1,*, Xiaoye Liao2, Fen Cai3

    International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1313-1321, 2023, DOI:10.32604/ijmhp.2023.030558

    Abstract Background: Elderly people with depression require special care and attention. However, nostalgia is a complex emotional situation for a person who recalls the missing past. To improve mental health, quality of life, and attitudes toward aging in institutional care, group nostalgia therapy can be a nursing intermediary for the elderly. This study aimed to analyze the effect of group nostalgia therapy on quality of life cognitive function in elderly patients with depression. Methods: A total of 89 participants were enrolled in this study, which was further categorized into a control (n = 40) and a nostalgia therapy group (n =… More >

  • Open Access

    ARTICLE

    Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells

    BEHROOZ JOHARI1,2,#,*, MILAD PARVINZAD LEILAN1,#, MAHMOUD GHARBAVI3, YOUSEF MORTAZAVI1, ALI SHARAFI2, HAMED REZAEEJAM4

    Oncology Research, Vol.32, No.2, pp. 309-323, 2024, DOI:10.32604/or.2023.043576

    Abstract The Myc gene is the essential oncogene in triple-negative breast cancer (TNBC). This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line. Decoy and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 gene. The nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan (Chi-Se-DEC), which was then encapsulated in niosome-nanocarriers (NISM@Chi-Se-DEC). FT-IR, DLS, FESEM, and hemolysis tests were applied to confirm its characterization and physicochemical properties. Moreover, cellular uptake, cellular toxicity, apoptosis, cell cycle, and scratch repair… More > Graphic Abstract

    Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells

  • Open Access

    ARTICLE

    Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma: Based on muti-omics analysis and vitro assay

    HONGYUAN LIANG1,#, YANQIU LI2,#, YONGGANG QU3, LINGYUN ZHANG4,*

    Oncology Research, Vol.32, No.2, pp. 393-407, 2024, DOI:10.32604/or.2023.031134

    Abstract Advanced LUAD shows limited response to treatment including immune therapy. With the development of sequencing omics, it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response markers. Using GSE72094 (n = 386) and GSE31210 (n = 226) gene expression profile data in the GEO database, we identified genes associated with lung adenocarcinoma (LUAD) death using tools such as “edgeR” and “maftools” and visualized the characteristics of these genes using the “circlize” R package. We constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression methods. By calculating the cell death… More >

  • Open Access

    ARTICLE

    Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients

    JUAN SHEN1,#, WEIYU ZHANG2,3,#, QINQIN JIN2,3,#, FUYU GONG4,#, HEPING ZHANG5, HONGLIANG XU5, JIEJIE LI2,3, HUI YAO2,3, XIYA JIANG2,3, YINTING YANG2,3, LIN HONG2,3, JIE MEI2,3, YANG SONG6,*, SHUGUANG ZHOU2,3,7,*

    Oncology Research, Vol.32, No.2, pp. 339-351, 2024, DOI:10.32604/or.2023.030887

    Abstract Background: Invasive breast carcinoma (BRCA) is associated with poor prognosis and high risk of mortality. Therefore, it is critical to identify novel biomarkers for the prognostic assessment of BRCA. Methods: The expression data of polo-like kinase 1 (PLK1) in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases. PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. Single sample gene set enrichment analysis (ssGSEA) was performed to evaluate immune infiltration in the BRCA microenvironment, and the random forest (RF) and support vector machine (SVM) algorithms… More >

  • Open Access

    ARTICLE

    Regulation of RNA methylation and immune infiltration patterns by m5C regulators in head and neck squamous cell carcinoma

    SHIDA HOU1,#, TIANJUN LAN2,#, YAOCHENG YANG3,#, PEISHENG LIANG1, XIN LIU4,5, JUNJIE WANG6, ZHIFENG CHEN7, RONGSHENG ZENG1,*, ZIJING HUANG8,*

    BIOCELL, Vol.47, No.12, pp. 2641-2660, 2023, DOI:10.32604/biocell.2023.043291

    Abstract Background: 5-Methylcytosine (m5C) methylation contributes to the development and progression of various malignant tumors. This study aimed to explore the potential role of m5C methylation regulators (m5CMRs) in head and neck squamous cell carcinoma (HNSCC). Methods: The transcription data of HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Subsequently, the m5C patterns in HNSCC were evaluated based on 14 m5CMRs. Then, the m5Cscore was developed to quantify m5C patterns by using principal component analysis (PCA) algorithms. Two single-cell RNA sequencing datasets and various methods were employed to assess the prognostic value… More >

  • Open Access

    ARTICLE

    Effects of platelets on characteristics of lymphocytes cultured in vitro and optimization of adoptive immunotherapy

    CONGLIANG CHEN#, XIAOHONG LENG#, YU ZHANG, JUNMEI HU, DAPENG WEI, PEIPEI WANG*, XIA WANG*

    BIOCELL, Vol.47, No.12, pp. 2661-2669, 2023, DOI:10.32604/biocell.2023.043084

    Abstract Background: T lymphocytes, the main participants of cellular immunity, can express a variety of surface molecules and form different lymphocyte subsets under the induction of different factors to play the functions of immune regulation and immune killing. Studies have shown that platelets play a crucial role in maintaining the stable differentiation of lymphocytes and the balance in immunomodulation. Therefore, it is necessary to study the effect of platelets on lymphocytes in vitro to better understand the role of platelets in the immune system and broaden the application of adoptive immunotherapy. Methods: Cell counting and microscopic observation were used to detect… More >

  • Open Access

    ARTICLE

    A Novel Unsupervised MRI Synthetic CT Image Generation Framework with Registration Network

    Liwei Deng1, Henan Sun1, Jing Wang2, Sijuan Huang3, Xin Yang3,*

    CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 2271-2287, 2023, DOI:10.32604/cmc.2023.039062

    Abstract In recent years, radiotherapy based only on Magnetic Resonance (MR) images has become a hot spot for radiotherapy planning research in the current medical field. However, functional computed tomography (CT) is still needed for dose calculation in the clinic. Recent deep-learning approaches to synthesized CT images from MR images have raised much research interest, making radiotherapy based only on MR images possible. In this paper, we proposed a novel unsupervised image synthesis framework with registration networks. This paper aims to enforce the constraints between the reconstructed image and the input image by registering the reconstructed image with the input image… More >

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