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    Hemodynamically significant patent ductus arteriosus and the development of bronchopulmonary dysplasia

    Kent A. Willis, Mark F. Weems

    Congenital Heart Disease, Vol.14, No.1, pp. 27-32, 2019, DOI:10.1111/chd.12691

    Abstract Patent ductus arteriosus (PDA) is prevalent in premature newborns and has been linked to the development of bronchopulmonary dysplasia (BPD), a serious pulmonary complication of premature birth. Although a causal relationship has not been proven, the link is greatest among infants born at lower gestational age who are treated with mechanical ventilation in the presence of a large ductal shunt. Despite strong association in epidemiological studies, treatment of a patent ductus arteriosus has not been shown to prevent BPD, and some therapies may increase the risk of BPD. We describe preclinical and clinical data demonstrating the association of a PDA… More >

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