LUIS MANUEL GONZáLEZ-RODRíGUEZ¹, LUIS MIGUEL JUáREZ-SALCEDO^1,*, JAVIER LOSCERTALES¹, EVA ARRANZ¹, JIMENA CANNATA-ORTIZ¹, JAVIER ORTIZ¹, MARIA JOSé LóPEZ DE LA OSA¹, ADRIáN ALEGRE¹, SAMIR DALIA^2,*

Oncology Research, Vol.33, No.3, pp. 505-517, 2025, DOI:10.32604/or.2025.058175 - 28 February 2025

Abstract T-prolymphocytic leukemia is a rare and aggressive hematological malignancy characterized by the clonal proliferation of mature lymphoid T-cells. The pathogenesis of T-PLL is closely linked to specific chromosomal abnormalities, primarily involving the proto-oncogene T-cell leukemia/lymphoma 1 gene family. Recent advancements in molecular profiling have identified additional genomic aberrations, including those affecting the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. This case report presents a patient with T-prolymphocytic leukemia whose cytogenetic and molecular analysis revealed a t(X;14)(q28;q11.2) translocation and a STAT5B mutation. Here, we aim to review the genetic and molecular underpinnings of T-prolymphocytic More >

Grace Helene Wegrzyn¹, Melissa Kilianek², Suzanne Iwaz³, Patricia Vidal¹, Ryan W. Dobbs¹

Canadian Journal of Urology, Vol.31, No.1, pp. 11809-11812, 2024

Abstract Mullerianosis is a rare, complex, benign tumor most commonly found in the bladder and often mistaken for a neoplastic lesion. Herein, we report a case of mullerianosis in a 65-year-old woman who presented with an incidental 2 cm bladder mass found on cross-sectional imaging. A mixed cystic and solid tumor was identified on cystoscopy and a transurethral resection of the suspected tumor was performed with histopathology confirming a final diagnosis of mullerianosis. While an unusual diagnosis, mullerianosis of the urinary bladder needs to be correctly identified to provide appropriate treatment and avoid misdiagnosis. More >

Matthew Buell, Brian Hu

Canadian Journal of Urology, Vol.31, No.5, pp. 12026-12029, 2024

Abstract Radical cystectomy is a preferred treatment for muscle invasive bladder cancer. Despite known complications, rapid onset, severe hyperkalemia necessitating abortion of surgery has not been reported. In this case report, a patient with end stage renal disease (ESRD) undergoing attempted cystectomy developed severe intraoperative hyperkalemia and acidosis that led to abortion of surgery and transfer to the medical intensive care unit for emergent hemodialysis. The multifactorial etiology was related to respiratory acidosis, ESRD, patient positioning, clipping of ureters, and body habitus, as well as an idiopathic element. Knowledge of hyperkalemia etiologies can assist in diagnosis More >

Mohamed Aashiq Abdul Ghayum^1,*, Maria Kiaffas^1,2, Ashley Warta¹, Melanie Kathol¹, David C. Mundy², Kelsey Brattrud¹, Nitin Madan^1,2

Congenital Heart Disease, Vol.19, No.6, pp. 647-651, 2024, DOI:10.32604/chd.2025.058271 - 27 January 2025

Abstract Prominent coronary artery (CA) flow observed on a fetal echocardiogram has been associated with fetal growth restriction and myocardial dysfunction. We present two cases with this finding, in the presence of congenital heart disease (CHD) and absence of growth restriction or myocardial dysfunction. Both the cases rapidly progressed to extremis, necessitating emergent delivery. Our cases highlight the importance of recognizing prominent CA flow in fetuses with CHD as a potential marker for in utero distress. More >

Hayatu Uma^1,*, Abdulaziz Aminu¹, Raghu Cherukupalli², Femi Akindotun Akintomide¹, Abdul Habu³, Aisha Aminu Lawal¹, Adamu Mohammad¹

Congenital Heart Disease, Vol.19, No.6, pp. 635-645, 2024, DOI:10.32604/chd.2025.056641 - 27 January 2025

Abstract Laubry-Pezzi syndrome (L-PS) is a rare congenital heart disease characterized by a ventricular septal defect (VSD) and aortic valve prolapse. These cardiac lesions predispose individuals to infective endocarditis (IE), a life-threatening complication, especially in resource-constrained settings. A 17-year-old male presented with a three-week history of fever and headache, and a one-week history of abdominal pain, vomiting, and diarrhea. On presentation, he appeared toxic, was febrile, tachypneic, tachycardic, and blood pressure of 120/30 mmHg, and heart sounds were S1, S2. Abdominal examination revealed generalized tenderness. A provisional diagnosis of typhoid sepsis with intestinal perforation was considered.… More >

Qiqi Shi^1,#, Xuan Lei^2,#, Wenbo Zhang^1,*, Ming Ye^1,*

Congenital Heart Disease, Vol.19, No.3, pp. 275-278, 2024, DOI:10.32604/chd.2024.051370 - 26 July 2024

Abstract Introduction: Transposition of the great arteries (TGA) with aortopulmonary window is a rare type of congenital heart disease with limited experience. We reported a neonate aged 25 days receiving the arterial switch operation and assisted with extracorporeal membrane oxygenation. Conclusion: TGA with aortopulmonary window can be safely correctly with the arterial switch operation. More >

Faris Najdawi¹, Shreya Lamba², Osamah Hasan¹, Patricia Vidal¹, Ryan Dobbs¹

Canadian Journal of Urology, Vol.30, No.1, pp. 11445-11447, 2023

Abstract Blastomyces dermatitidis is an environmental fungus endemic to parts of Eastern North America that notably causes pulmonary infection in humans and other animals with the potential for extrapulmonary spread, particularly in immunocompromised hosts. However, it rarely presents with genitourinary (GU) tract involvement. Herein, we present a unique case of a 37-year-old immunocompetent male with genitourinary blastomycosis with the initial presentation of a scrotal abscess. More >

Dian Kesumarini^1,2, Yunita Widyastuti³, Cindy Elfira Boom¹, Lucia Kris Dinarti^4,*

Congenital Heart Disease, Vol.18, No.6, pp. 671-678, 2023, DOI:10.32604/chd.2023.044746 - 19 January 2024

Abstract Tetralogy of Fallot (TOF) with total anomalous pulmonary vein connections (TAPVC) is a rare type of complex congenital heart disease among all TOF cases. Co-presentation of major aortopulmonary collateral arteries (MAPCAs) compensates for the lack of central pulmonary blood flow and decreases the severity of right-to-left shunting in TOF. We present a case of a 2-year-old child with complex diagnoses of TOF, TAPVC, a large secundum atrial septal defect (ASD), and intraoperatively identified MAPCAs. She underwent surgery to repair the TAPVC, valve-sparing reconstruction of the right ventricular outflow tract, interventricular defect closure, and the creation… More >

Niccola B. Lynch¹, Rena D. Malik²

Canadian Journal of Urology, Vol.29, No.3, pp. 11194-11197, 2022

Abstract Total pelvic exenterations (TPE) are high morbidity procedures, with up to 38% of patients experiencing a major complication after TPE surgery. We report the case of a 69-year-old woman with a sigmoid conduit-neovaginal fistula who presented with new onset continuous vaginal leakage and decreased urostomy output 3 months post-op from a TPE. We highlight the presentation, diagnosis, conservative management, and surgical management of conduit-vaginal fistulas. More >

Roberta Costanzo¹, Vishal Parmar², Salvatore Marrone¹, Domenico Gerardo Iacopino¹, Giovanni Federico Nicoletti³, Giuseppe Emmanuele Umana⁴, Gianluca Scalia^3,*

Oncologie, Vol.24, No.4, pp. 937-942, 2022, DOI:10.32604/oncologie.2022.027155 - 31 December 2022

Abstract Primary intracranial melanomas are rare, with a challenging diagnosis based only on clinical and imaging features. The authors described the case of an intracerebral right parieto-temporal melanoma mimicking a cavernoma in a patient affected by Crohn’s disease. A 67-year-old female patient with Crohn’s disease and small bowel stenosis was hospitalized for surgical removal of the terminal ileum and latero-lateral ileo-colic anastomosis. During postoperative week 1, the patient developed psychomotor agitation followed by altered consciousness. An urgent brain CT showed a right intracerebral parieto-temporal hemorrhage with intralesional calcifications. The patient underwent a decompressive craniectomy with hematoma More >