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Differential Diagnosis between Primary Intracranial Melanoma and Cerebral Cavernoma in Crohn’s Disease: A Case Report and Literature Review

Roberta Costanzo1, Vishal Parmar2, Salvatore Marrone1, Domenico Gerardo Iacopino1, Giovanni Federico Nicoletti3, Giuseppe Emmanuele Umana4, Gianluca Scalia3,*

1 Neurosurgery Unit, Department of Biomedicine, Neurosciences & Advanced Diagnostics, School of Medicine, University of Palermo, Palermo, Italy
2 School of Medicine, American University of Integrative Sciences, Cole Bay, Barbados
3 Department of Neurosurgery, Highly Specialized Hospital and of National Importance “Garibaldi”, Catania, Italy
4 Department of Neurosurgery, Trauma Center, Gamma Knife Center, Cannizzaro Hospital, Catania, Italy

* Corresponding Author: Gianluca Scalia. Email: email

Oncologie 2022, 24(4), 937-942. https://doi.org/10.32604/oncologie.2022.027155

Abstract

Primary intracranial melanomas are rare, with a challenging diagnosis based only on clinical and imaging features. The authors described the case of an intracerebral right parieto-temporal melanoma mimicking a cavernoma in a patient affected by Crohn’s disease. A 67-year-old female patient with Crohn’s disease and small bowel stenosis was hospitalized for surgical removal of the terminal ileum and latero-lateral ileo-colic anastomosis. During postoperative week 1, the patient developed psychomotor agitation followed by altered consciousness. An urgent brain CT showed a right intracerebral parieto-temporal hemorrhage with intralesional calcifications. The patient underwent a decompressive craniectomy with hematoma drainage and a complete resection of the lesion. Histologic examination showed characteristics consistent with malignant melanoma. In patients with inflammatory bowel disease (IBD), the differential diagnosis between intracerebral melanoma and cavernoma may be challenging, considering the similar clinical and radiological findings. Thus, a comprehensive multidisciplinary approach is required to exclude the possible coexistence of such intracranial lesions.

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Cite This Article

Costanzo, R., Parmar, V., Marrone, S., Iacopino, D. G., Nicoletti, G. F. et al. (2022). Differential Diagnosis between Primary Intracranial Melanoma and Cerebral Cavernoma in Crohn’s Disease: A Case Report and Literature Review. Oncologie, 24(4), 937–942.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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