Xiaoyue Feng^1,#, Yu Liu^2,#, Ying Kang¹, Juan Wei², Bei Yuan³, Kang Jiang⁴, Weijun Xu², Xinyi Xia⁵, Fangyu Wang^1,*

BIOCELL, Vol.49, No.8, pp. 1505-1528, 2025, DOI:10.32604/biocell.2025.066504 - 29 August 2025

Abstract Objectives: A common side effect of inflammatory bowel disease (IBD) is intestinal fibrosis, which frequently leads to intestinal blockage and stricture formation. Although Thalidomide (THD) has shown anti-fibrotic benefits in hepatic and renal models, little is known about how it affects intestinal fibrosis and the underlying processes. The present research examines the molecular targets of THD and its potential as a treatment for intestinal fibrosis brought on by colitis. Methods: Clinical samples from Crohn’s disease (CD) patients with intestinal strictures treated with infliximab (IFX) and THD combined with IFX were collected. Dextran sulfate sodium (DSS)… More >

Roberta Costanzo¹, Vishal Parmar², Salvatore Marrone¹, Domenico Gerardo Iacopino¹, Giovanni Federico Nicoletti³, Giuseppe Emmanuele Umana⁴, Gianluca Scalia^3,*

Oncologie, Vol.24, No.4, pp. 937-942, 2022, DOI:10.32604/oncologie.2022.027155 - 31 December 2022

Abstract Primary intracranial melanomas are rare, with a challenging diagnosis based only on clinical and imaging features. The authors described the case of an intracerebral right parieto-temporal melanoma mimicking a cavernoma in a patient affected by Crohn’s disease. A 67-year-old female patient with Crohn’s disease and small bowel stenosis was hospitalized for surgical removal of the terminal ileum and latero-lateral ileo-colic anastomosis. During postoperative week 1, the patient developed psychomotor agitation followed by altered consciousness. An urgent brain CT showed a right intracerebral parieto-temporal hemorrhage with intralesional calcifications. The patient underwent a decompressive craniectomy with hematoma More >

MARLA DE CERQUEIRA ALVES¹, MONISE OLIVEIRA SANTOS¹, NASSIB BEZERRA BUENO¹, ORLANDO ROBERTO PIMENTEL DE ARAÚJO², MARÍLIA OLIVEIRA FONSECA GOULART^2,3,4, FABIANA ANDRÉA MOURA^1,5,*

BIOCELL, Vol.46, No.9, pp. 2015-2047, 2022, DOI:10.32604/biocell.2022.020407 - 18 May 2022

Abstract

The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in

… More >

Gregory Wade¹, Stanley Zaslau², Robert Jansen²

Canadian Journal of Urology, Vol.21, No.2, pp. 7179-7184, 2014

Abstract Introduction: Urinary fistulae develop as abnormal connections between the gastrointestinal (GI) and genitourinary (GU) tracts, and occur in multiple disease processes including diverticulitis, malignancy, and Crohn’s disease. Crohn’s disease is now the most common cause of fistula formation between the ileum and bladder and the third most common cause of fistulae between the colon and the bladder. Few articles provide a comprehensive review of this process.
Materials and methods: We performed a PubMed search using such terms as “fistula” and “Crohn’s disease” and/or “enterovesical fistula.” We reviewed references from selected papers and relevant articles were used for… More >

Marine Desroches, Gauthier Louis, Aude Gleizes, Roman Krzysiek, Dominique Emilie

European Cytokine Network, Vol.21, No.4, pp. 226-231, 2010, DOI:10.1684/ecn.2010.0212

Abstract The use of TNF-α antagonists has substantially improved the care of many patients with inflam-matory and autoimmune diseases. However, approximately one third of such patients fail to respond well totreatment, regardless of the antagonist used or of the underlying disease. The mechanisms underlying these fail-ures are analyzed in this review, and proposals made concerning how best to adapt therapeutic decisions inthese instances. More >

Caroll J. Beltrán^1,2*, Enzo Candia^1*, Benjamín Erranz¹, Carolina Figueroa³, Maria J. Gonzalez⁴, Rodrigo Quera^3,5, Marcela A. Hermoso¹

European Cytokine Network, Vol.20, No.1, pp. 33-38, 2009, DOI:10.1684/ecn.2009.0142

Abstract Crohn’s disease (CD) and ulcerative colitis (UC) belong to the group of inflammatory bowel dis-eases (IBD), with complex ethiopathogenic factors that include an unbalanced immune and inflammatory response to commensal and food antigens. The differential diagnosis between CD and UC is performed using clinical, endoscopic, histopathological, serological and radiological methods; however between 10-15% of IBD patients are diagnosed as “unclassified colitis”. Further research into IBD is necessary in order to develop addi-tional diagnostic tools. The aim of this work was to see if the Th1, Th17 or Th2 immune pattern, represented by CD4+ lymphocytes producing… More >

Caroll J. Beltrán^1,2, Enzo Candia¹, Benjamín Erranz¹, Carolina Figueroa³, Maria J. Gonzalez⁴, Rodrigo Quera^3,5, Marcela A. Hermoso¹

European Cytokine Network, Vol.20, No.2, pp. 94-94, 2009, DOI:10.1684/ecn.2009.0151

Abstract This article has no abstract. More >

Evelien Bodar^1,3, Mihai G. Netea^1,3, Dirk J. de Jong², Bart-Jan Kullberg^1,3, Leo A. B. Joosten^1,3, Jos W. M. Van der Meer^1,3

European Cytokine Network, Vol.19, No.4, pp. 185-189, 2008, DOI:10.1684/ecn.2008.0140

Abstract Background. NOD2/CARD15 is a member of the NACHT-LRR (NLR) family of proteins, which recognize the muramyl dipeptide motif from bacterial peptidoglycans. NOD2 has been shown to be involved in the pathogenesis of Crohn’s disease. NLR proteins modulate inflammation and apoptosis, and several studies have implicated NOD2 in the induction of cytokines and inflammatory reactions. However, only scarce data are available regarding its role in apoptosis. Donors and methods. Neutrophils and lymphocytes isolated from the blood from four Crohn’s disease patients homozygous for the loss-of-function 3020insC NOD2 mutation were examined for spontaneous and anisomycin-induced apoptosis. They More >