MARLA DE CERQUEIRA ALVES1, MONISE OLIVEIRA SANTOS1, NASSIB BEZERRA BUENO1, ORLANDO ROBERTO PIMENTEL DE ARAÚJO2, MARÍLIA OLIVEIRA FONSECA GOULART2,3,4, FABIANA ANDRÉA MOURA1,5,*
BIOCELL, Vol.46, No.9, pp. 2015-2047, 2022, DOI:10.32604/biocell.2022.020407
Abstract
The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in animals treated with curcumin.… More >