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Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: A systematic review of animal models and a meta-analysis of randomized clinical trials

MARLA DE CERQUEIRA ALVES1, MONISE OLIVEIRA SANTOS1, NASSIB BEZERRA BUENO1, ORLANDO ROBERTO PIMENTEL DE ARAÚJO2, MARÍLIA OLIVEIRA FONSECA GOULART2,3,4, FABIANA ANDRÉA MOURA1,5,*

1 Programa de Pós-Graduação em Nutrição (PPGNUT), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
2 Instituto de Química e Biotecnologia (IQB), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
3 Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
4 Programa de Pós-Graduação da Rede Nordeste de Biotecnologia (RENORBIO), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil
5 Programa de Pós-Graduação em Ciências Médicas (PPGCM), Universidade Federal de Alagoas (UFAL), Maceió, AL 57072-970, Brazil

* Corresponding Author: FABIANA ANDRÉA MOURA. Email: email

BIOCELL 2022, 46(9), 2015-2047. https://doi.org/10.32604/biocell.2022.020407

Abstract

The roots of the vegetal Curcuma due to its high content of polyphenols, has been used successfully in several clinical situations. This review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease (IBD). A systematic review of animal models and randomized clinical trials (RCTs) was conducted by searching the following electronic databases: PubMed, CENTRAL, LILACS, Science Direct, and ClinicalTrials.gov. From 997 found records, 62 were included. More than 90% of the animal studies reported an improvement in macroscopic, histologic and/or functional activity; 80% identified decreased oxidative and/or inflammatory biomarkers in animals treated with curcumin. Among the RCTs, intention-to-treat analysis showed that oral curcumin was effective in inducing clinical remission (n = 281, RR: 3.15 CI 95% [1.22–8.10] p = 0.0017; i² = 72.2%, p = 0.006) and clinical response (n = 259, RR: 1.60 CI 95% [1.09–2.35] p = 0.0017; i² = 59.7%, p = 0.042) but not endoscopic remission (n = 161, RR: 2.91 CI 95% [0.58–14.58] p = 0.195; i² = 72.7%, p = 0.026). These results confirm that oral supplementation with curcumin/Curcuma longa has beneficial actions in animal colitis and, when associated with drug therapy, is effective in the treatment of patients with IBD.


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APA Style
ALVES, M.D.C., SANTOS, M.O., BUENO, N.B., ARAÚJO, O.R.P.D., GOULART, M.O.F. et al. (2022). Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: A systematic review of animal models and a meta-analysis of randomized clinical trials. BIOCELL, 46(9), 2015-2047. https://doi.org/10.32604/biocell.2022.020407
Vancouver Style
ALVES MDC, SANTOS MO, BUENO NB, ARAÚJO ORPD, GOULART MOF, MOURA FA. Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: A systematic review of animal models and a meta-analysis of randomized clinical trials. BIOCELL . 2022;46(9):2015-2047 https://doi.org/10.32604/biocell.2022.020407
IEEE Style
M.D.C. ALVES, M.O. SANTOS, N.B. BUENO, O.R.P.D. ARAÚJO, M.O.F. GOULART, and F.A. MOURA "Efficacy of oral consumption of curcumin/ for symptom improvement in inflammatory bowel disease: A systematic review of animal models and a meta-analysis of randomized clinical trials," BIOCELL , vol. 46, no. 9, pp. 2015-2047. 2022. https://doi.org/10.32604/biocell.2022.020407



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