Login
Register
Submit a Paper
Propose a Special lssue
Open Access
REVIEW
Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients
Inserm U996, Service de microbiologie-Immunologie Biologique, Hôpital Antoine-Béclère, Université Paris-Sud, Clamart, France
* Corresponding Author: Pr D. Emilie,
European Cytokine Network 2010, 21(4), 226-231. https://doi.org/10.1684/ecn.2010.0212
Accepted 27 September 2010;
Download PDFAbstract
The use of TNF-α antagonists has substantially improved the care of many patients with inflam-matory and autoimmune diseases. However, approximately one third of such patients fail to respond well totreatment, regardless of the antagonist used or of the underlying disease. The mechanisms underlying these fail-ures are analyzed in this review, and proposals made concerning how best to adapt therapeutic decisions inthese instances.Keywords
TNF-α, monoclonal antibodies, biotherapies, rheumatoid arthritis, Crohn’s disease, ankylosing spondylitis
Cite This Article
APA Style
Desroches, M., Louis, G., Gleizes, A., Krzysiek, R., Emilie, D. (2010). Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients. European Cytokine Network, 21(4), 226–231. https://doi.org/10.1684/ecn.2010.0212
Vancouver Style
Desroches M, Louis G, Gleizes A, Krzysiek R, Emilie D. Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients. Eur Cytokine Network. 2010;21(4):226–231. https://doi.org/10.1684/ecn.2010.0212
IEEE Style
M. Desroches, G. Louis, A. Gleizes, R. Krzysiek, and D. Emilie, “Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients,” Eur. Cytokine Network, vol. 21, no. 4, pp. 226–231, 2010. https://doi.org/10.1684/ecn.2010.0212
Copyright © 2010 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Downloads
Citation Tools
