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  • Open Access

    REVIEW

    Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies

    Raquel Sanchez-Baltasar1, Nerea Castañeda-Fernández1, Jorge Olivares-Arancibia2, Carlos Torres-Villar3,4, Julio Plaza-Diaz5,6,7,8,*, Lourdes Herrera-Quintana1,*

    Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081924 - 16 June 2026

    Abstract Breast cancer (BC) is the most frequently diagnosed malignancy in women worldwide and remains one of the leading causes of cancer-related mortality, with substantial international disparities in incidence, stage at diagnosis, access to treatment, and survival. In recent years, BC management has evolved rapidly through advances in molecular characterization, imaging, pathology, targeted therapies, immunotherapy, and survivorship care. Nevertheless, important gaps persist in early and accurate detection, biomarker standardization, equitable access to care, and patient-specific treatment selection. These advances require timely, evidence-based, and context-specific clinical frameworks to support appropriate implementation, and to avoid the use of… More >

  • Open Access

    REVIEW

    Clinical Application Progress of Artificial Intelligence in Pancreatic Cancer: From Diagnosis to Immunotherapy

    Zehao Wei1,#, Xuejian Liu2,#, Zheng Zhang1, Yimin Ma2,*, Min Xu1,*

    Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.078793 - 16 June 2026

    Abstract Pancreatic cancer is one of the most lethal malignancies, characterized by difficulties in early diagnosis, limited therapeutic options, and generally poor patient prognosis. In recent years, immunotherapy has provided new opportunities for the treatment of pancreatic cancer; however, its clinical efficacy has been substantially constrained by the complex tumor microenvironment (TME) and immune evasion mechanisms. With the rapid advancement of artificial intelligence (AI) technologies, AI has demonstrated great potential in the early detection of pancreatic cancer, prediction of immunotherapeutic responses, and design of personalized treatment strategies. This review systematically summarizes the latest advances in the More >

  • Open Access

    ARTICLE

    Research on Gearbox Fault Diagnosis Method Based on Multi-Dimensional Feature Extraction and Random Forest

    Yu Zhang1,2,#, Shihan Tan1,#, Guangyao Lian2, Congying Dun3, Qiwei Hu1,*, Chiming Guo1,*

    CMC-Computers, Materials & Continua, Vol.88, No.2, 2026, DOI:10.32604/cmc.2026.081931 - 15 June 2026

    Abstract Gearboxes are critical components in the transmission systems of various mechanical equipment. Subjected to complex and harsh operating conditions for a long time, they suffer from a high failure rate and potentially severe consequences. Traditional fault diagnosis methods are limited by problems such as noise interference, and can hardly meet the requirements in terms of diagnostic accuracy, generalization ability, and reliability. To tackle the deficiencies of traditional gearbox fault diagnosis methods, including insufficient utilization of features, poor generalization under small-sample conditions, and weak model interpretability, this paper proposes a fault diagnosis method based on multi-dimensional… More >

  • Open Access

    ARTICLE

    Research on Agricultural Machinery Fault Nested Entity Extraction for Low-Resource and High-Noise Scenes

    Huaixuan Yan, Yan Gong*

    CMC-Computers, Materials & Continua, Vol.88, No.2, 2026, DOI:10.32604/cmc.2026.080178 - 15 June 2026

    Abstract To correctly diagnose faults in farm machinery, we need to know a lot about the field and have experience with maintenance. However, most of this important information is stored in old, unstructured documents like technical manuals and expert logs. These documents don’t have a standard way to be represented digitally, which makes it very hard to build automated diagnosis systems. There are three main technical problems with getting structured knowledge out of this kind of text: noise from optical character recognition (OCR) during digitization, the extreme lack of labeled samples in specialized fields (low-resource constraints),… More >

  • Open Access

    ARTICLE

    The Effect of Prenatal Diagnosis of Critical Congenital Heart Disease on Postnatal Mortality and Morbidity: A Retrospective Cohort Study

    Aygül Kaya Akıllı1, Osman Akdeniz2, Celal Özcan3,*

    Structural and Congenital Heart Disease, Vol.21, No.2, 2026, DOI:10.32604/schd.2026.076628 - 11 June 2026

    Abstract Background: Congenital heart disease (CHD) refers to malformations of the heart or great vessels that occur during the intrauterine period. Critical CHD refers to heart conditions that require medical intervention or surgical procedures in the early stages of life. Methods: In this retrospective cohort study, newborns aged 0 to 28 days who were admitted to the Neonatal Intensive Care Unit and the Pediatric Cardiovascular Surgery Clinic of our hospital with a diagnosis of critical CHD between January 2019 and September 2024 were evaluated. Results: Among 160 patients, 52 (32.5%) had a prenatal diagnosis. Overall mortality was significantly… More >

  • Open Access

    ARTICLE

    TransCP-Net: Transformer-Based Spatiotemporal Pose Representation for Early Screening of Infant Cerebral Palsy

    Amel Ksibi1,*, Manel Ayadi1, Hela Elmannai2, Monia Hamdi2, Ala Saleh Alluhaidan1, Imen Ksibi3

    CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.2, 2026, DOI:10.32604/cmes.2026.078347 - 27 May 2026

    Abstract Cerebral palsy is a prevalent neurodevelopmental syndrome that disrupts motor development in children, making early detection vital for effective intervention. Traditional clinical assessments rely on subjective observations, often missing minor motor abnormalities until they become severe, typically after 12 months of age. This article presents a novel deep learning model, TransCP-Net (Transformer-based Cerebral Palsy Network), designed for early detection of infant cerebral palsy through spatiotemporal pose representation learning. The architecture employs hierarchical spatial and temporal attention to analyze complex motion patterns in video sequences, integrating multi-modal data for improved accuracy. TransCP-Net incorporates specialized preprocessing, including More >

  • Open Access

    ARTICLE

    Hierarchical Cyber–Physical Symbiosis with Bidirectional State Space Modeling for IIoT Anomaly Diagnosis

    Kelan Wang1, Jianfei Chen2,*

    CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.079644 - 08 May 2026

    Abstract As 6G-enabled Industrial Internet of Things (IIoT) evolves, green and sustainable industrial monitoring increasingly relies on edge AI to deliver low-latency diagnosis under tight resource constraints. Industrial cyber–physical systems increasingly rely on heterogeneous sensing and communication infrastructures, where network-side attacks can propagate into physical processes and appear as coupled anomalies. Reliable diagnosis therefore requires joint learning from time-synchronized cyber and physical telemetry rather than modeling them as independent signals. This paper develops Cyber–Physical Symbiosis Network (CPSNet), a model designed for edge-AI deployment with a dual-stream architecture for fixed-window multiclass cross-domain anomaly diagnosis in IIoT. CPSNet… More >

  • Open Access

    ARTICLE

    Factors Influencing Length of Stay and Symptom Improvement among Psychiatric Patients by Diagnosis: Analysis of the Korea National Survey

    Soo-Hyun Sung1, Seungwon Shin2, Seok-Hwan Kim3, Minjung Park4,*

    International Journal of Mental Health Promotion, Vol.28, No.4, 2026, DOI:10.32604/ijmhp.2026.077710 - 28 April 2026

    Abstract Objectives: Psychiatric inpatient care plays a critical role in stabilizing acute mental health crises, yet the optimal length of stay (LOS) and its impact on short-term clinical outcomes remain poorly defined across diagnostic groups. This study aimed to examine how LOS in psychiatric inpatient units is associated with clinical improvement at discharge and to determine whether this association differs across major diagnostic groups, using nationally representative hospital discharge data from Korea. Methods: A cross-sectional secondary analysis was conducted using the 2022–2023 Korea National Hospital Discharge In-depth Injury Survey. Adults whose primary discharge diagnosis was a mental… More >

  • Open Access

    ARTICLE

    An Intelligent Signal Classification Framework for Crack Detection in Polymeric Materials Using Ensemble Learning

    Rafael de Oliveira Silva1,2,*, Roberto Outa3, Fábio Roberto Chavarette4

    CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.1, 2026, DOI:10.32604/cmes.2026.080607 - 27 April 2026

    Abstract The reliable detection of cracks in engineering materials remains a fundamental challenge in nondestructive testing, especially in applications that require automated inspection, reduced instrumentation costs, and robustness under noisy operational conditions. Traditional nondestructive evaluation techniques often rely on complex sensing setups or expert-dependent interpretation, which can limit scalability and real-time applicability. In this context, this study addresses the scientific problem of achieving reliable and automated crack detection using simplified sensing architectures combined with intelligent data-driven analysis. This work proposes an intelligent signal classification framework for crack detection in polymeric materials based on machine learning and… More >

  • Open Access

    ARTICLE

    An Improved Support Vector Machine Method for Fault Diagnosis of Inter-Turn Short Circuit in PMSM with Enhanced Fault Representation

    Yue Su1, Shukuan Zhang1,*, Jinghao Jiao1, Jiankang Zhong2, Qianxi Zhao1

    CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.1, 2026, DOI:10.32604/cmes.2026.079927 - 27 April 2026

    Abstract This paper introduces a novel dual-layer optimization fault diagnosis framework for inter-turn short-circuit (ITSC) faults in permanent magnet synchronous motors (PMSMs). The synergistic of a SABO-optimized VMD for enhanced feature extraction and an MFO-optimized SVM for intelligent classification is proposed. Firstly, mathematical and simulation models of ITSC faults in PMSMs are established to obtain fault phase currents and motor electromagnetic torques as characteristic fault signals. Then, the SABO algorithm is used to optimize the VMD parameters, followed by VMD decomposition of the characteristic fault signals to obtain Intrinsic Mode Functions (IMFs), and the time-domain parameters More >

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