Roland Mangold, Timea Teglas^*

BIOCELL, Vol.49, No.12, pp. 2239-2244, 2025, DOI:10.32604/biocell.2025.069925 - 24 December 2025

Abstract The quality of life in older adulthood is greatly influenced by cognitive aging, which in turn is affected by nutrition, especially as it relates to hippocampal function. Although the link between hippocampal function and nutrition is defined, the exact mechanics are still unknown. The commentary addresses how docosahexaenoic acid (DHA) contributes to age-related cognitive decline and may play a role in promoting neurogenesis and neuroplasticity on the molecular level. The current challenge to our understanding is to investigate how DHA influences hippocampal function and cognitive aging, which would be possible and even more detailed with More >

Hongsheng Su¹, Wenyao Su¹, Yulong Che^1,*, Xiping Ma², Tian Zhao¹, Limiao Ren¹

Energy Engineering, Vol.122, No.11, pp. 4777-4797, 2025, DOI:10.32604/ee.2025.068134 - 27 October 2025

Abstract Aiming at the issues of insufficient carrying capacity, limited flexibility, and weak source-network-load-storage coordination capability in distribution networks under the background of high-proportion new energy integration. This study proposes a bi-level optimization model for ADN integrating hybrid wind-solar-hydrogen-storage systems. First, an electro-hydrogen coupling system framework is constructed, including models for electrolytic hydrogen production, hydrogen storage, and fuel cells. Meanwhile, typical scenarios of wind-solar joint output are developed using Copula functions to characterize the variability of renewable energy generation. Second, a bi-level optimization model for ADN with electrolytic hydrogen production and storage systems is established: the… More >

Jingfu Yan, Huachun Zhou^*, Weilin Wang

Computer Systems Science and Engineering, Vol.49, pp. 499-531, 2025, DOI:10.32604/csse.2025.068151 - 10 October 2025

Abstract The 6G network architecture introduces the paradigm of Trust + Security, representing a shift in network protection strategies from external defense mechanisms to endogenous security enforcement. While ZTNs (zero-trust networks) have demonstrated significant advancements in constructing trust-centric frameworks, most existing ZTN implementations lack comprehensive integration of security deployment and traffic monitoring capabilities. Furthermore, current ZTN designs generally do not facilitate dynamic assessment of user reputation. To address these limitations, this study proposes a DPZTN (Data-plane-based Zero Trust Network). DPZTN framework extends traditional ZTN models by incorporating security mechanisms directly into the data plane. Additionally, blockchain infrastructure… More > Graphic Abstract

Ikhtesham Ullah¹, Muhammad Sajjad Ali Khan², Fawad Hussain¹, Madad Khan³, Kamran^4,*, Ioan-Lucian Popa^5,6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2123-2164, 2025, DOI:10.32604/cmes.2025.064832 - 31 August 2025

Abstract Multi-criteria decision-making (MCDM) is essential for handling complex decision problems under uncertainty, especially in fields such as criminal justice, healthcare, and environmental management. Traditional fuzzy MCDM techniques have failed to deal with problems where uncertainty or vagueness is involved. To address this issue, we propose a novel framework that integrates group and overlap functions with Aczel-Alsina (AA) operational laws in the intuitionistic fuzzy set (IFS) environment. Overlap functions capture the degree to which two inputs share common features and are used to find how closely two values or criteria match in uncertain environments, while the… More >

Shengmin Li¹, Kejian Shi¹, Ying Wang^2,*, Yi Zhang^1,*

Oncology Research, Vol.33, No.9, pp. 2435-2449, 2025, DOI:10.32604/or.2025.063812 - 28 August 2025

Abstract Objectives: Lung cancer represents a major global healthcare challenge, characterized by high annual incidence and mortality rates worldwide. Although targeted therapies for lung cancer have advanced, treatment outcomes for advanced-stage patients remain suboptimal. This investigation examines the role of the translocase of the inner mitochondrial membrane (TIMM)8A-TIMM13 complex in lung cancer and evaluates its potential as a novel therapeutic target. Methods: A co-immunoprecipitation (Co-IP) assay was conducted to verify the interaction between TIMM8A and TIMM13. Differential gene expression analysis of TIMM8A or TIMM13 was executed using the TNMplot database, with survival estimates derived from the… More >

Sunil K. Singh¹, Sudhakar Kumar^1,*, Manraj Singh¹, Savita Gupta², Razaz Waheeb Attar³, Varsha Arya^4,5, Ahmed Alhomoud⁶, Brij B. Gupta^7,8,9

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 3927-3941, 2025, DOI:10.32604/cmc.2025.059643 - 03 July 2025

Abstract As quantum computing continues to advance, traditional cryptographic methods are increasingly challenged, particularly when it comes to securing critical systems like Supervisory Control and Data Acquisition (SCADA) systems. These systems are essential for monitoring and controlling industrial operations, making their security paramount. A key threat arises from Shor’s algorithm, a powerful quantum computing tool that can compromise current hash functions, leading to significant concerns about data integrity and confidentiality. To tackle these issues, this article introduces a novel Quantum-Resistant Hash Algorithm (QRHA) known as the Modular Hash Learning Algorithm (MHLA). This algorithm is meticulously crafted… More >

Mohammed Althubyani^1,*, Nidal E. Taha², Khdija O. Taha², Rasmiyah A. Alharb², Sayed Saber^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 3491-3521, 2025, DOI:10.32604/cmes.2025.061640 - 30 June 2025

Abstract This study investigates the dynamics of pneumococcal pneumonia using a novel fractal-fractional Susceptible-Carrier-Infected-Recovered model formulated with the Atangana-Baleanu in Caputo (ABC) sense. Unlike traditional epidemiological models that rely on classical or Caputo fractional derivatives, the proposed model incorporates nonlocal memory effects, hereditary properties, and complex transmission dynamics through fractal-fractional calculus. The Atangana-Baleanu operator, with its non-singular Mittag-Leffler kernel, ensures a more realistic representation of disease progression compared to classical integer-order models and singular kernel-based fractional models. The study establishes the existence and uniqueness of the proposed system and conducts a comprehensive stability analysis, including local More >

Seyha Ros^1,#, Seungwoo Kang^1,#, Taikuong Iv¹, Inseok Song¹, Prohim Tam², Seokhoon Kim^1,3,*

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 1649-1665, 2025, DOI:10.32604/cmc.2025.062716 - 16 April 2025

Abstract Recently, Network Functions Virtualization (NFV) has become a critical resource for optimizing capability utilization in the 5G/B5G era. NFV decomposes the network resource paradigm, demonstrating the efficient utilization of Network Functions (NFs) to enable configurable service priorities and resource demands. Telecommunications Service Providers (TSPs) face challenges in network utilization, as the vast amounts of data generated by the Internet of Things (IoT) overwhelm existing infrastructures. IoT applications, which generate massive volumes of diverse data and require real-time communication, contribute to bottlenecks and congestion. In this context, Multi-access Edge Computing (MEC) is employed to support resource… More >

Chen Lin^1,*, Zidan Zhang¹, Zhao Zhang¹, Yuxiang Long¹, Xuwen Shen¹, Jinghao Zhang¹, Youping Wang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 583-601, 2025, DOI:10.32604/phyton.2025.063086 - 31 March 2025

Abstract Glutathione S-transferases (GSTs) represent a large and diverse enzyme family ubiquitously distributed across the plant kingdom. These proteins catalyze the conjugation of glutathione (GSH) with electrophilic substrates in response to various stress conditions. Beyond their role in stress adaptation, certain GSTs are integral regulators of plant growth and development, contributing to a range of physiological processes. Most GST proteins exhibit dual enzymatic activities, functioning as both transferases and peroxidases, which enables their involvement in diverse cellular processes, including detoxification and stress responses. Recent advancements, particularly in X-ray crystallography, have enabled detailed structural analysis of GST More >

Xiaojian Chen^1,2,#, Zhujiang Dai^1,#, Qiang Wang³, Wei Chen¹, Yun Liu^1,*, Zhongchuan Wang^1,*

BIOCELL, Vol.49, No.3, pp. 503-518, 2025, DOI:10.32604/biocell.2025.059286 - 31 March 2025

Abstract Background: Nudix Hydrolase 21 (NUDT21) is crucial for the regulation of alternative polyadenylation, with its reduced expression frequently resulting in a shortened mRNA 3^′ untranslated region (UTR), thereby enhancing the protein levels of downstream genes. Although NUDT21 is widely recognized for its tumor-suppressive function in various cancers, its involvement in colorectal cancer (CRC) remains poorly understood. Methods: The expression of NUDT21 in CRC and adjacent normal tissues was analyzed through qPCR, Western blot, and immunohistochemistry (IHC). Additionally, we investigated the correlation between NUDT21 expression and patient prognosis. With Cell Counting Kit-8 assay and Transwell assay, we… More >