Awatif Rashed Z. Almotairy1,2, Eman Fayad3, Fatimah Hadadi4, Ahmad F. Alhomodi5, Dalal Nasser Binjawhar6, Hanadi A. Katouah7, Bassma H. Elwakil8,*, Keshav Raj Paudel9,10,*, Mostafa El-Khatib11
Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.070645
- 23 March 2026
Abstract Objectives: Prostate cancer cells often develop mechanisms to evade conventional therapies. Nanomedicine offers the potential for targeted drug delivery, improved tumor accumulation, and reduced systemic toxicity. This study biosynthesizes silver nanoparticles (NPP/AgONPs) functionalized with propolis, evaluates their antibacterial efficacy against uropathogenic strains of Escherichia coli (E. coli), and assesses their cytotoxic effect on cancer cell proliferation using the PC-3, human prostate epithelial cell line. Methods: The synthesized NPP/AgONPs physiochemical parameters were characterized, followed by in vitro assays to evaluate their antibacterial activity against multiple uropathogenic E. coli strains; determining the cytotoxicity against HPrEC and PC-3 cells by measuring cytotoxicity (CC50)… More >