CHENHAO SHI¹, MAOHONG HUA², GUANHUA XU^3,*

BIOCELL, Vol.47, No.6, pp. 1329-1344, 2023, DOI:10.32604/biocell.2023.028381

Abstract Background: Ulcerative colitis (UC) is a chronic disease that often presents with abdominal pain, diarrhea, hematochezia, and significant morbidity. Gancao Xiexin decoction (GXD), a traditional Chinese medicine, has been applied for the clinical treatment of UC, while its action mechanisms are unclear. Methods: The active ingredients and their targets of GXD, and UC-related targets, were derived from public databases. Protein-protein interaction, Gene Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analyze the important active compounds, key targets, and signaling pathways. Then, molecular docking and animal experiments were performed to verify the findings. A total… More >

H. Shalma, P. Selvaraj^*

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 1145-1161, 2023, DOI:10.32604/iasc.2023.036853

Abstract The creation of the 3D rendering model involves the prediction of an accurate depth map for the input images. A proposed approach of a modified semi-global block matching algorithm with variable window size and the gradient assessment of objects predicts the depth map. 3D modeling and view synthesis algorithms could effectively handle the obtained disparity maps. This work uses the consistency check method to find an accurate depth map for identifying occluded pixels. The prediction of the disparity map by semi-global block matching has used the benchmark dataset of Middlebury stereo for evaluation. The improved depth map quality within a… More >

Hassam Tahir¹, Muhammad Shahbaz Khan¹, Fawad Ahmed², Abdullah M. Albarrak³, Sultan Noman Qasem³, Jawad Ahmad^4,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3517-3535, 2023, DOI:10.32604/cmc.2023.035410

Abstract The COVID-19 outbreak began in December 2019 and was declared a global health emergency by the World Health Organization. The four most dominating variants are Beta, Gamma, Delta, and Omicron. After the administration of vaccine doses, an eminent decline in new cases has been observed. The COVID-19 vaccine induces neutralizing antibodies and T-cells in our bodies. However, strong variants like Delta and Omicron tend to escape these neutralizing antibodies elicited by COVID-19 vaccination. Therefore, it is indispensable to study, analyze and most importantly, predict the response of SARS-CoV-2-derived t-cell epitopes against Covid variants in vaccinated and unvaccinated persons. In this… More >

Teng Zong^1,2,*, Fengsi Wang³, Xin Wei², Yibo Liu¹

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3447-3468, 2023, DOI:10.32604/iasc.2023.035456

Abstract With the expanding enrollments in higher education, the quality of college education and the learning gains of students have attracted much attention. It is important to study the influencing factors and mechanisms of individual students’ acquisition of learning gains to improve the quality of talent cultivation in colleges. However, in the context of information security, the original data of learning situation surveys in various universities involve the security of educational evaluation data and daily privacy of teachers and students. To protect the original data, data feature mining and correlation analyses were performed at the model level. This study selected 12,181… More >

Honglu He, Zhiying Zhu, Xinpeng Zhang^*

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.3, pp. 2617-2633, 2023, DOI:10.32604/cmes.2023.025923

Abstract In recent years, the number of parameters of deep neural networks (DNNs) has been increasing rapidly. The training of DNNs is typically computation-intensive. As a result, many users leverage cloud computing and outsource their training procedures. Outsourcing computation results in a potential risk called backdoor attack, in which a welltrained DNN would perform abnormally on inputs with a certain trigger. Backdoor attacks can also be classified as attacks that exploit fake images. However, most backdoor attacks design a uniform trigger for all images, which can be easily detected and removed. In this paper, we propose a novel adaptive backdoor attack.… More >

PRIYANKA SOLANKI¹, NISARG RANA¹, PRAKASH C. JHA², ANU MANHAS^1,*

BIOCELL, Vol.47, No.4, pp. 707-729, 2023, DOI:10.32604/biocell.2023.026615

Abstract Cancer is considered one of the most lethal diseases responsible for causing deaths worldwide. Although there have been many breakthroughs in anticancer development, cancer remains the major cause of death globally. In this regard, targeting cancer-causing enzymes is one of the efficient therapeutic strategies. Biological functions like cell cycle, transcription, metabolism, apoptosis, and other depend primarily on cyclin-dependent kinases (CDKs). These enzymes help in the replication of DNA in the normal cell cycle process, and deregulation in the functioning of any CDK can cause abnormal cell growth, which leads to cancer. This review is focused on anticancer drug discovery against… More >

ZHIXUN XIAO¹, QIUYUN XU¹, HAIQING WANG¹, XIAOTONG ZHOU², YANTING ZHU¹, CHENGBEI BAO¹, LIHONG CHEN¹, PENG ZHANG¹, MIN LIN¹, CHAO JI^1,*, TING GONG^3,*

Oncology Research, Vol.31, No.1, pp. 71-82, 2023, DOI:10.32604/or.2022.028075

Abstract Cutaneous squamous cell carcinoma (cSCC), a type of non-melanoma skin cancer (NMSC), is the most common malignancy worldwide. Thioredoxin (TXN) domain-containing protein 9 (TXNDC9) is a member of the TXN family that is important in cell differentiation. However, the biological function of this protein in cancer, particularly cSCC, is still unknown. In the present study, our experiments revealed the protective effects of TXNDC9 on UV-B-irritated cSCC cells. The initial findings showed that TXNDC9 is significantly upregulated in cSCC tissue and cells compared to normal skin tissue and keratinocytes. UV-B radiation robustly induces the expression of TXNDC9, and UV-B-induced cSCC cell… More >

Haowen Wu¹, Zhanli Yi¹, Tianyou Guo^2,*

International Journal of Mental Health Promotion, Vol.25, No.3, pp. 375-387, 2023, DOI:10.32604/ijmhp.2022.021505

Abstract Background: Adolescents are highly vulnerable to depressive symptoms worldwide partially because of limited social supports. However, it still remains largely unknown regarding the associations between social support(s) and depressive symptoms among adolescents living in low- and middle-income countries (LMICs). The aim of this study aimed to explore the associations between different types of social support and depressive symptoms in adolescents from LMICs. Methods: Data were retrieved from the Global School-based Health Survey (GSHS) in which 92,551 adolescents (50.6% females) were included with mean of 15.6 years. Depressive symptoms in the past one month as the dependent variable were measured in… More >

Ruaa H. Abbas¹, A. Kadhim^1,*, Azhar M. Haleem²

Journal of Renewable Materials, Vol.11, No.5, pp. 2109-2123, 2023, DOI:10.32604/jrm.2023.025112

Abstract Copper oxide nanoparticles (CuO NPs) were synthesised with laser ablation of a copper sheet immersed in deionized water (DW), cetrimonium bromide (CTAB), and sodium dodecyl sulphate (SDS), respectively. The target was irradiated with a pulsed Nd: YAG laser at 1064 nm, 600 mJ, a pulse duration of 10 ns, and a repetition rate of 5 Hz. The CuO NPs colloidal were analyzed using UV–Vis spectroscopy, the Fourier transform infrared (FTIR) spectrometer, zeta potential (ZP), X-ray diffraction (XRD), transmission electron microscope (TEM) and field emission scanning electron microscopy (FESEM). The absorption spectra of CuO NPs colloidal showed peaks at 214, 215… More >

K. Jayanthi^1,*, A. M. Kalpana²

Computer Systems Science and Engineering, Vol.46, No.2, pp. 1689-1705, 2023, DOI:10.32604/csse.2023.034613

Abstract The fifth-generation (5G) wireless technology is the most recent standardization in communication services of interest across the globe. The concept of Multiple-Input-Multiple-Output antenna (MIMO) systems has recently been incorporated to operate at higher frequencies without limitations. This paper addresses, design of a high-gain MIMO antenna that offers a bandwidth of 400 MHz and 2.58 GHz by resonating at 28 and 38 GHz, respectively for 5G millimeter (mm)-wave applications. The proposed design is developed on a RT Duroid 5880 substrate with a single elemental dimension of 9.53 × 7.85 × 0.8 mm³. The patch antenna is fully grounded and is fed with a 50-ohm stepped impedance… More >