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  • Open Access

    REVIEW

    Prostate specific membrane antigen (PSMA) as a biomarker in early and localized advanced prostate cancer: a narrative review

    Jonathon Carll1,2,3,*, Jacinta Bonaddio1, Dixon Woon1,4,5, Marlon Perera1,4,5,6, Nathan Lawrentschuk2,3,5,6, Thilakavathi Chengodu1,3

    Canadian Journal of Urology, Vol.33, No.1, pp. 21-34, 2026, DOI:10.32604/cju.2025.068908 - 28 February 2026

    Abstract Prostate-specific membrane antigen (PSMA) is a surface membrane antigen that is highly overexpressed in prostate cancer, with heterogenous expression throughout the natural history of the disease. This has generated significant interest as a potential biomarker for use in early diagnosis and treatment of prostate cancer. We reviewed the literature surrounding PSMA and its current clinical applications in diagnosing and managing early prostate cancer that is confined to the prostate and local lymph nodes. A search on PubMed, Medline, and Web of Science was performed using the following keywords: “PSMA”, “Prostate Specific Membrane Antigen”, “Prostate cancer”,… More >

  • Open Access

    ARTICLE

    Geometrically Nonlinear Analyses of Isotropic and Laminated Shells by a Hierarchical Quadrature Element Method

    Yingying Lan, Bo Liu*

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2026.075706 - 29 January 2026

    Abstract In this work, the Hierarchical Quadrature Element Method (HQEM) formulation of geometrically exact shells is proposed and applied for geometrically nonlinear analyses of both isotropic and laminated shells. The stress resultant formulation is developed within the HQEM framework, consequently significantly simplifying the computations of residual force and stiffness matrix. The present formulation inherently avoids shear and membrane locking, benefiting from its high-order approximation property. Furthermore, HQEM’s independent nodal distribution capability conveniently supports local p-refinement and flexibly facilitates mesh generation in various structural configurations through the combination of quadrilateral and triangular elements. Remarkably, in lateral buckling… More >

  • Open Access

    SHORT COMMUNICATION

    RNF213 Formed and Decorated Membrane-Based Structures in U-2 OS Cells

    TOSHIYUKI HABU*

    BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.071798 - 23 January 2026

    Abstract RING protein 213 (RNF213), the susceptibility gene for Moyamoya disease (MMD), possesses two active AAA+ ATPase (ATPases Associated with diverse cellular Activities) modules, a RING, and RNF213-ZNFX1 finger (RZ finger) domains. Several RNF213 variants have been reported in MMD patients, including the p.R4810K variant (rs112735431), which is a founder polymorphism associated with MMD in East Asia. To elucidate the function of RNF213 and its variant, we investigated the localization of RNF213 and the R4810K variant in this study. RNF213 induced circular hole structures near the nucleus, similar to lipid droplets (LDs), in U-2 OS cells. More >

  • Open Access

    ARTICLE

    Post-Norwood Extracorporeal Membrane Oxygenation—The Complex Interplay of Cardiopulmonary Bypass and Myocardial Ischemic Time

    Ryan G. McQueen1, Paulina M. Gutkin2, George M. Hoffman3, Ronald K. Woods4,*

    Congenital Heart Disease, Vol.20, No.6, pp. 683-692, 2025, DOI:10.32604/chd.2025.075838 - 10 February 2026

    Abstract Objective: The objective of this study was to understand intraoperative risk factors for post-Norwood extracorporeal membrane oxygenation (ECMO) in patients with hypoplastic left heart syndrome (HLHS). Methods: We conducted a retrospective, single-institution review of all patients with HLHS who underwent a Norwood procedure (nadir cardiopulmonary bypass temperature ≤ 22°C) over a 12-year period with quantitative and qualitative analysis. Results: Of 102 Norwood patients, 14 (13.7%) required ECMO. ECMO patients had longer median cardiopulmonary bypass (CPB) times (276 vs. 172 min, p < 0.001) and myocardial ischemic times (98.5 vs 83 min, p = 0.021). Longer CPB time was More >

  • Open Access

    ARTICLE

    Life Cycle Assessment of Solar-Assisted Post-Combustion CO2 Capture Using Hollow Fiber Membrane Contactors

    Lei Wang1, Hongyang Zhou2, Xiaofan Liu3, Junkun Mu2, Jinpeng Bi2, Youkang Jin2, Juan Ge2, Yuexia Lv2,4,*

    Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 1811-1832, 2025, DOI:10.32604/fhmt.2025.071222 - 31 December 2025

    Abstract Membrane gas absorption and solar-assisted absorbent regeneration offer a sustainable approach to reduce the energy penalty of post-combustion CO2 capture. This study introduces a novel system integrating solar thermal energy with membrane gas absorption to capture CO2 from a 580 MWe pulverized coal power plant. The environmental impacts across six scenarios at varying solar fractions are evaluated via life cycle assessment. Results show a 7.61%–13.04% reduction in global warming potential compared to a steam-driven CO2 capture system. Electricity and steam consumption dominate the operational phase, contributing 15%–64% and 18%–61% to environmental impacts in non-TES scenarios, respectively. While More >

  • Open Access

    ARTICLE

    Performance Evaluation of Hierarchically Structured Superhydrophobic PVDF Membranes for Heavy Metals Removal via Membrane Distillation

    Pooja Yadav1,*, Ramin Farnood2, Vivek Kumar1,*

    Journal of Polymer Materials, Vol.42, No.4, pp. 1181-1197, 2025, DOI:10.32604/jpm.2025.072564 - 26 December 2025

    Abstract Heavy metal contamination in water sources is a widespread global concern, particularly in developing nations, with various treatment approaches under extensive scientific investigation. In the present study, we fabricated electrospun composite polyvinylidene fluoride (PVDF) nanofibrous membranes exhibiting hierarchical surface roughness and superhydrophobicity for the removal of heavy metal ions via vacuum membrane distillation (VMD) process. The membranes were prepared by incorporating optimized dosing of silica nanoparticles, followed by a two-step membrane modification approach. These membranes exhibited notable characteristics, including elevated water contact angle (152.8 ± 3.2°), increased liquid entry pressure (127 ± 6 kPa), and… More > Graphic Abstract

    Performance Evaluation of Hierarchically Structured Superhydrophobic PVDF Membranes for Heavy Metals Removal via Membrane Distillation

  • Open Access

    ARTICLE

    Bi-Crown-Ether Modified Bi-Piperidinium Anion Exchange Membranes for Fuel Cell Applications

    Minghao Yuan1,2, Lingling Ma1,2, Lv Li1,2, Shoutao Gong1,2, Lei Bai1,2, Yanzhen Ren1,2, Xinli Zhang1,2, Naeem Akhtar Qaisrani3,*, Fengxiang Zhang1,2,*

    Journal of Polymer Materials, Vol.42, No.4, pp. 893-908, 2025, DOI:10.32604/jpm.2025.071240 - 26 December 2025

    Abstract Anion exchange membrane (AEM) fuel cells require membranes with a balance of high conductivity and durability. In this work, a novel bi-crown-ether modified piperidine structure was designed and synthesized, which was then introduced into the side chain of poly(arylene piperidinium), making a unique bi-crown-ether modified bi-piperidinium side chain grafted polymer for AEM fabrication. The double crown ether units enhanced cation–water interactions and promoted microphase separation, thereby forming efficient hydroxide ion transport channels. The resulting membrane exhibited high water uptake, well-defined ion clusters, and a hydroxide conductivity of 123 mS cm−1 at 80°C with an ion exchange More >

  • Open Access

    ARTICLE

    A New Quadrilateral Finite Element Formulation for the Free Vibration Analysis of CNT-Reinforced Plates with Cutouts

    Boudjema Bendaho1, Abdelhak Mesbah1, Zakaria Belabed1,2,*

    CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 2781-2805, 2025, DOI:10.32604/cmc.2025.069709 - 23 September 2025

    Abstract A new quadrilateral finite element IQ4 is developed for the free vibration of carbon nanotube-reinforced composite (CNTRC) perforated plates with a central cutout. By enriching the membrane part and incorporating a projected shear technique, the IQ4 element is proposed to address the known limitations of the standard Q4 element, such as shear locking and limited consistency in the coupling of membrane-bending components. The proposed element is formulated within the FSDT-based framework and assessed through benchmark tests to verify its convergence and accuracy. The governing equations are obtained via the weak form of Hamilton’s principle. Particular… More >

  • Open Access

    ARTICLE

    Preoperative ECMO Bridging in Pediatric Heart Transplantation: A Cohort Study on Graft Remodeling, Inflammatory Biomarkers and Survival

    Hui Yi1,2,#, Hongjian Shi2,3,#, Fuquan Kan2,4,#, Fan Han2, Lei Wan5, Xiaoyang Hong1, Zhe Zhao1, Junjie Shao2, Gang Wang1, Hui Wang1, Hua Yan5, Xiujuan Shi1, Ran Zhang2,6,*, Gengxu Zhou1,*

    Congenital Heart Disease, Vol.20, No.4, pp. 519-530, 2025, DOI:10.32604/chd.2025.067164 - 18 September 2025

    Abstract Background: To investigate the impact of preoperative extracorporeal membrane oxygenation (ECMO) on clinical outcomes in pediatric heart transplantation (PHT). Methods: This retrospective cohort analysis was conducted on 19 pediatric heart transplant recipients, divided into two groups: ECMO and non-ECMO, based on whether preoperative ECMO was utilized. We evaluated the patients’ surgical conditions, postoperative complications, and survival rates. Additionally, the analysis focused on the differences and correlations in clinical characteristics, inflammatory markers, and long-term survival outcomes. Results: There was no statistically significant difference in perioperative survival rates between the ECMO group (85.7%) and the non-ECMO group (83.3%). However,… More >

  • Open Access

    ARTICLE

    Dual-Stream Deep Learning for Health Monitoring of HDPE Geomembranes in Landfill Containment Systems

    Yuhao Zhang1,2,3, Peiqiang Zhao1,2, Xing Chen1,2, Shaoxuan Zhang4, Xinglin Zhang1,2,*

    Structural Durability & Health Monitoring, Vol.19, No.5, pp. 1343-1365, 2025, DOI:10.32604/sdhm.2025.066558 - 05 September 2025

    Abstract The structural integrity monitoring of high-density polyethylene (HDPE) geomembranes in landfill containment systems presents a critical engineering challenge due to the material’s vulnerability to mechanical degradation and the complex vibration propagation characteristics in large-scale installations. This study proposes a dual-stream deep learning framework that synergistically integrates raw vibration signal analysis with physics-guided feature extraction to achieve precise rupture detection and localization. The methodology employs a hierarchical neural architecture comprising two parallel branches: a 1D convolutional network processing raw accelerometer signals to capture multi-scale temporal patterns, and a physics-informed branch extracting material-specific resonance features through continuous More >

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