GUANGXIAN YOU¹, QIAO YANG², XIN LI², LILI CHEN^2,*

Oncology Research, Vol.33, No.4, pp. 905-917, 2025, DOI:10.32604/or.2024.052089 - 19 March 2025

Abstract Background: Lung cancer remains a major factor causing cancer-associated mortality globally. While there have been advancements in treatment options, advanced lung cancer patients still have poor outcomes. This study aims to investigate the potential role of Transmembrane protein 33 (TMEM33) in the development of lung adenocarcinoma. Methods: We leveraged The Cancer Genome Atlas (TCGA) database to analyze the connection between TMEM33 expression to the prognosis of lung adenocarcinoma (LUAD). Cell proliferation, invasiveness, and sphere formation were analyzed by various experiments. The association of miR-214-3p with TMEM33 was explored using luciferase reporter assay, immunoblotting, and real-time… More >

Abiodun Abdulhameed Amusa^1,*, Anwar Johari¹, Kamil Kayode Katibi^2,3, Ibrahim Garba Shitu^4,5, Abdulrahman Oyekanmi Adeleke⁶, Mohd Fairus Mohd Yasin⁷, Muhammad Thalhah Zainal⁸

Journal of Renewable Materials, Vol.13, No.2, pp. 251-272, 2025, DOI:10.32604/jrm.2025.057487 - 20 February 2025

Abstract The increasing severity of air pollution necessitates more effective and sustained air filtration technology. Concurrently, the desire for more environmentally friendly, sustainable materials with better filtering performance and less environmental impact drives the move away from conventional synthetic membranes. This review presents lignocellulosic biocomposite (LigBioComp) membranes as an alternative to traditional synthetic membranes. It focuses on their materials, fabrication, and functionalization techniques while exploring challenges and proposing methods for resourceful utilization. Renowned for their abundance and renewable nature, lignocellulosic materials consist of cellulose, hemicellulose, and lignin. Various applications can benefit from their antibacterial properties,… More > Graphic Abstract

HAIYING PANG^1,#, FENGBO WU^1,#, YU ZHANG¹, NAN ZHANG², CHUNTING WANG¹, QIU LI¹, GU HE^1,*, PENG ZHANG^3,*

Oncology Research, Vol.33, No.2, pp. 443-464, 2025, DOI:10.32604/or.2024.043948 - 16 January 2025

Abstract Background: EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family. EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues, where it may play a role in either promoting or inhibiting tumor growth. This study aimed to investigate the expression level, biological functions, and molecular mechanisms of EMP2 in liver cancer. Methods: we analyzed the mRNA expression levels of EMPs family genes in hepatocellular carcinoma (HCC) tissues and normal liver tissues based on the TCGA database and immunohistochemical analysis of tissue microarrays. Subsequently, we constructed HCC cell… More > Graphic Abstract

XIUWANG WEI¹, JIANBO LIANG¹, HUANWEN HUANG¹, DAMING YANG¹, XINXIN WANG¹, XIUJIA WANG¹, CHANGSHENG CHEN¹, KAIQIANG LI¹, TAISEN PANG¹, BIN HU¹, FENGNING WU^2,*

Oncology Research, Vol.33, No.1, pp. 161-169, 2025, DOI:10.32604/or.2024.048054 - 20 December 2024

Abstract Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear. Materials and Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer in vitro and in vivo. Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells. In vitro, shTMED3 treatment suppressed the proliferation, invasion, and migration and promoted the apoptosis of DU145 cells. Additionally, the Kyoto Encyclopedia… More >

Choon-Peng Chng¹, Changjin Huang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.011464

Abstract Biological membranes play crucial roles in cellular functions, serving as dynamic interfaces that regulate the passage of molecules and signals between the cell and its environment. Understanding how these membranes respond to environmental stimuli is paramount in elucidating cellular adaptation and survival mechanisms. In this talk, we will present our recent studies on the structural and mechanical changes of biological membranes in response to two different environmental factors, including the presence of reactive oxygen species (ROS) and dehydration. Through systematic molecular dynamics simulations, we have revealed a dynamic interplay between membrane components, membrane mechanics and… More >

Christin Rina Ratri^1,2, Qolby Sabrina², Adam Febriyanto Nugraha¹, Sotya Astutiningsih¹, Mochamad Chalid^1,*

Journal of Renewable Materials, Vol.12, No.11, pp. 1863-1878, 2024, DOI:10.32604/jrm.2024.055492 - 22 November 2024

Abstract Commercial lithium-ion batteries (LIBs) use polyolefins as separators. This has led to increased research on separators composed of renewable materials such as cellulose and its derivatives. In this study, the ionic conductivity of cellulose acetate (CA) polymer electrolyte membranes was enhanced via plasticization with citric acid and succinonitrile. The primary objective of this study was to evaluate the effectiveness of these plasticizers in improving cellulose-based separator membranes in LIBs. CA membranes were fabricated using solution casting technique and then plasticized with various concentrations of plasticizers. The structural, thermal, and electrochemical properties of the resulting membranes… More > Graphic Abstract

Xin Yi^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.3, pp. 1-1, 2024, DOI:10.32604/icces.2024.012558

Abstract The intricate packing of elastic filaments, including cytoskeletal microtubules, actin filaments, and artificial nanotubes, is fundamental to understanding a plethora of cellular functions and their applications in cellular engineering. Through rigorous theoretical analysis, we investigate the packing dynamics of filaments within vesicles and explore the axial stretching of the vesicle–filament system. Our examination reveals how the interplay of stiffness and size ratios between filaments and vesicles drives transitions in vesicle configurations, prompting filament bending or coiling. We construct morphological phase diagrams to elucidate these transitional phenomena, highlighting the influence of pressurized vesicles in enhancing resistance More >

Yeye Liu¹, Leilei Zhang^1,*, Ruonan Zhang¹, Siqi Shao¹, Lina Sun¹, Xinyi Wan¹, Tiantian Wang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.2, pp. 1-1, 2024, DOI:10.32604/icces.2024.012576

Abstract Superior thermal insulating and fire-retardant ceramic membranes are urgently demanded in the aerospace, construction and chemical engineering industries. However, the generic characteristics of ceramic membranes, such as brittleness, structural collapse and crystallization-induced pulverization behavior, present a great plague to their practical applications. Herein, we report a highly flexible, mechanically stable, fire retardant and high-temperature-resistant ceramic membrane based on the interlocked Si₃N₄ nanowires formed by the precursor pyrolysis method. The Si₃N₄ nanowires membrane (SNM) has excellent high temperature resistance under alcohol lamp and butane spray lance. The thermal insulation with a thermal conductivity as low as 0.056… More >

Salma Moushi^1,*, Jaouad Ait lahcen¹, Ahmed El Hana¹, Yassine Ezaier¹, Ahmed Hader^1,2, Imane Bakassi¹, Iliass Tarras¹, Yahia Boughaleb^1,3

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2509-2521, 2024, DOI:10.32604/fdmp.2024.053501 - 28 October 2024

Abstract Multi-layer membrane filtration is a widely used technology for separating and purifying different components of a liquid mixture. This technique involves passing the liquid mixture through a series of membranes with decreasing pore sizes, which allows for the separation of different components according to their molecular size. This study investigates the filtration process of a fluid through a two-dimensional porous medium designed for seawater desalination. The focus is on understanding the impact of various parameters such as the coefficient of friction, velocity, and the number of layers on filtration efficiency. The results reveal that the More >

Anuraag Moturi, Dharmesh R. Chejara^*

Journal of Polymer Materials, Vol.41, No.3, pp. 179-190, 2024, DOI:10.32604/jpm.2024.055887 - 30 September 2024

Abstract A chitosan and guar protein isolate blend conjugate (Ch/GPI-Glu) based membrane has been designed and studied for its possible interaction with this biopolymer mixture. The designed conjugate chitosan/guar protein isolate blended membrane was investigated for its structural features using Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM) analyses. IR Spectroscopic data suggested that chitosan and guar protein isolate contributed to a specific intermolecular interaction. The designed membrane was water-insoluble and it exhibited strong polymer–protein interaction. Further, the membrane was also found to have a smooth morphology More >