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  • Open Access

    ARTICLE

    Numerical Study of Hydrogen Crossover Evolution Inside the Proton Exchange Membrane Fuel Cell under Dynamic Load

    Wenxin Luo1, Kaiwen Wang1, Pugalenthiyar Thondaiman2, Qianqian Wang1,*

    Frontiers in Heat and Mass Transfer, Vol.24, No.3, 2026, DOI:10.32604/fhmt.2026.082228 - 29 June 2026

    Abstract Hydrogen (H2) crossover in proton exchange membrane fuel cells (PEMFCs) reduces performance and poses safety risks, but its behavior under rapidly changing loads, which are common in vehicles, is not well understood. To address this, we developed a three-dimensional, two-phase, non-isothermal model that tracks H2 from dissolution in the anode, through transport across the membrane, to reaction at the cathode. The analysis shows that diffusion dominates whereas convection contributes little. Key findings are as follows: H2 crossover reduces the open-circuit voltage by 210 mV and raises cathode temperature by approximately 0.2°C; reducing the membrane thickness from 20… More >

  • Open Access

    ARTICLE

    Lycium Barbarum Polysaccharides Upregulate Trx2 in Schwann Cells through ESR1 to Repair Sciatic Nerve Injury in Rats

    Guoxu Ma, Yonglu Huang, Fan Gong, Jianke Wu, Yi Ding, Ziyang Zhang, Xiaoliang Li, Jian Gao, Tingting Dang, Bowen Zhang*

    BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.078402 - 09 June 2026

    Abstract Objectives: Sciatic nerve injury (SNI) impairs quality of life, and Lycium barbarum polysaccharides (LBP) may exert therapeutic effects via regulating Schwann cell (SC) mitochondrial stability, though the mechanism remains unclear. The study aimed to elucidate the therapeutic mechanisms of LBP in mitigating sciatic nerve injury by protecting Schwann cells via the estrogen receptor 1 (ESR1)/thioredoxin 2 (Trx2) pathway. Methods: An in vitro SNI model was established by inducing RSC96 cells with H2O2. Cell counting kit-8 (CCK8) assay, enzyme-linked immunosorbent assay (ELISA), Western blot, reactive oxygen species (ROS) and adenosine triphosphate (ATP) quantification, and mitochondrial membrane potential (MMP) detection were… More >

  • Open Access

    ARTICLE

    Multi-Objective Optimization of a Tapered Cathode Flow Channel in a Proton Exchange Membrane Fuel Cell

    Wei Dong1, Baoqi Guo2, Weiwei Zhao2, Hui Jian2, Zhenzong He2,*

    Frontiers in Heat and Mass Transfer, Vol.24, No.2, 2026, DOI:10.32604/fhmt.2025.075848 - 30 April 2026

    Abstract This study explores the design of a tapered cathode flow channel in a proton exchange membrane fuel cell (PEMFC), leveraging artificial intelligence and multi-objective optimization techniques to attain an optimal configuration. First, the influence of the channel height ratio and mass flow rate on PEMFC performance was systematically examined. The results reveal that decreasing the height ratio and increasing the mass flow rate lead to reduction in the standard deviation of current density, accompanied by a monotonic rise in pressure drop. The average current density initially rises before exhibiting a slight decline. Subsequently, a surrogate… More >

  • Open Access

    ARTICLE

    Effect of Temperature on the Performance of Proton Exchange Membrane Fuel Cell at Atomic Scales

    Saddam Husain Dhobi1,2,*, Kishori Yadav2, Suresh Prasad Gupta2,*, Jeevan Jyoti Nakarmi1, Ajay Kumar Jha3

    Energy Engineering, Vol.123, No.5, 2026, DOI:10.32604/ee.2026.076691 - 27 April 2026

    Abstract Increasing requirements on clean, efficient, and sustainable energy technologies have raised interest in hydrogen fuel cells, particularly proton exchange membrane fuel cells (PEMFCs), which are operationally characterized by high efficiency with zero emissions. The objective of this work is to study the scattering behaviors of particles participating in scattering under various conditions (energy, efficiency, temperature, cell voltage) at/around the electrode of PEMFC theoretically. For this, we developed a model using a scattering matrix, the Kroll-Watson approximation, the thermal wave function of an electron in a laser field, interaction potential, and Bessel functions to study the… More > Graphic Abstract

    Effect of Temperature on the Performance of Proton Exchange Membrane Fuel Cell at Atomic Scales

  • Open Access

    CASE REPORT

    Robot-assisted partial nephrectomy during simultaneous extracorporeal membrane oxygenation and impella® in a candidate for left ventricular assist device as a bridge for cardiac transplant: a case report

    Francesco Cianflone1, Giuseppe Ottone Cirulli1, Alessio Villano1, Mohammad Eisa Ali1, Mirko Belliato2, Roberto Veronesi2, Germana Bichisao3, Carlo Marchetti1, Simona Secondino4, Paolo Pedrazzoli4,5, Stefano Pelenghi6, Carlo Pellegrini6,7, Andrea Ringressi1, Richard Naspro1,7,*

    Canadian Journal of Urology, Vol.33, No.2, pp. 459-470, 2026, DOI:10.32604/cju.2025.073002 - 20 April 2026

    Abstract Background: Robot-assisted partial nephrectomy (RAPN) is standard for cT1 renal masses, but its feasibility in patients on temporary mechanical circulatory support is poorly documented. We report RAPN performed while a patient was simultaneously supported with venous-arterial extracorporeal membrane oxygenation (VA ECMO) and Impella®, as part of a staged plan for left ventricular assist device (LVAD) implantation and eventual heart transplantation. Case Presentation: A 51-year-old man presented with ST-elevation myocardial infarction complicated by cardiogenic shock requiring percutaneous coronary intervention with stenting, dual antiplatelet therapy, and combined VA ECMO–Impella® support. During workup for cardiac transplant, computed tomography (CT) staging… More >

  • Open Access

    REVIEW

    Multifunctional Carbonaceous Nanoreinforced Polymeric Nanofibers—Bridging Fundamental Aspects to Technological Resolves

    Ayesha Kausar*

    Journal of Polymer Materials, Vol.43, No.1, 2026, DOI:10.32604/jpm.2026.078233 - 03 April 2026

    Abstract Purpose of this novel review article is to unfold the current scientific worth of high performance polymer nanocomposite nanofibers, owing to growing scientific interests in this field. Accordingly, this state-of-the-art manuscript has been systematically categorized into distinct sections related to (i) fundamentals of carbonaceous nanoreinforcements, (ii) design-structure-property-performance aspects of different categories of polymer nanocomposite nanofibers (conducting polymers, thermoplastics, and thermosets with carbonaceous nanofillers (carbon nanotubes, graphene, fullerene), and then (iii) existing scientific worth (energy devices, electronics, space/defense, environmental sectors), future prospects, challenges, and conclusions. As per literature to date, polymer/carbonaceous nanocomposite nanofibers had myriad of advantageous physical… More > Graphic Abstract

    Multifunctional Carbonaceous Nanoreinforced Polymeric Nanofibers—Bridging Fundamental Aspects to Technological Resolves

  • Open Access

    ARTICLE

    Zein Membrane Barrier for Bone Guided Regeneration

    Cristiane Michele Alves de Oliveira1, Bruna Carolina Dorm1, Antonio José Felix Carvalho2, Deliane da Silva Cabral2, Flávia Aparecida Resende Nogueira1, Nádia Andrade Aleixo1, Mônica Rosas Costa Iemma1, Eliane Trovatti1,*

    Journal of Renewable Materials, Vol.14, No.3, 2026, DOI:10.32604/jrm.2025.02025-0166 - 25 March 2026

    Abstract Materials from natural sources have been studied to replace the conventional synthetic or animal-derived products as a safer alternative to be used in the healthcare field. In dentistry, guided bone regeneration (GBR) relies on barrier membranes, predominantly from animals or synthetic materials, to improve osteogenesis by avoiding undesired soft tissue cells from defect sites. In this study, membranes were prepared from zein, a corn-derived protein, using a simple extraction and casting method, followed by optional formaldehyde cross-linking to evaluate their behavior for application in GBR. The membranes were characterised by FTIR, DSC, TGA, tensile strength… More > Graphic Abstract

    Zein Membrane Barrier for Bone Guided Regeneration

  • Open Access

    REVIEW

    Recent Advances in Radiopharmaceuticals for Cancer Diagnosis and Therapy

    Ye Ri Han1,*, Sang Bong Lee2,3,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.075923 - 23 March 2026

    Abstract Radiopharmaceuticals deliver diagnostic or therapeutic radionuclides to disease sites with molecular precision. Over the past five years, clinical adoption has accelerated, led by U.S. Food and Drug Administration approvals of 177Lu-DOTA-TATE and 177Lu-PSMA-617 and their complementary Positron Emission Tomography agents (68Ga-DOTA-TATE, 68Ga-PSMA-11), which have established radiotheranostics as a pillar of oncology care. The new generation of agents couples optimized radionuclides (β, α, and Auger emitters) to antibodies, peptides, and small-molecule vectors that improve tumor uptake, residence time, and clearance profiles, thereby enhancing efficacy and safety. Beyond neuroendocrine tumors and prostate cancer, radiotheranostic strategies are advancing for diverse malignancies… More >

  • Open Access

    ARTICLE

    Sunitinib and Fenofibrate as Combination Therapy for MDR Glioblastoma: Insights from In Vitro and In Silico Studies

    Saad Alobid1,#, Hussam Albassam1,#, Tebyan O. Mirgany2, Faris Almutairi1, Mohammed Mufadhe Alanazi1, Ahmed H. Bakheit2, Hanadi H. Asiri2, Eram Eltahir3, Gamaleldin I. Harisa3,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.073371 - 23 March 2026

    Abstract Objective: Glioblastoma (GB) therapy is challenged by tumor heterogeneity and multidrug resistance (MDR), highlighting the need for effective therapies. This study aimed to explore the combined anticancer effects of Sunitinib (SNB) and Fenofibrate (FEN) on U87 cells. Methods: U87 cells were exposed to SNB, FEN, or their combination for 24 h, followed by evaluations of cell viability, migration, and clonogenic survival using MTT, scratch, and colony formation assays. Intracellular reactive oxygen species (ROS) were quantified via the 2, 7-dichlorofluorescein assay, while mitochondrial membrane potential (MMP) was assessed using JC-1 red/green fluorescence. Molecular docking was performed to… More > Graphic Abstract

    Sunitinib and Fenofibrate as Combination Therapy for MDR Glioblastoma: Insights from <i>In Vitro</i> and <i>In Silico</i> Studies

  • Open Access

    REVIEW

    Prostate specific membrane antigen (PSMA) as a biomarker in early and localized advanced prostate cancer: a narrative review

    Jonathon Carll1,2,3,*, Jacinta Bonaddio1, Dixon Woon1,4,5, Marlon Perera1,4,5,6, Nathan Lawrentschuk2,3,5,6, Thilakavathi Chengodu1,3

    Canadian Journal of Urology, Vol.33, No.1, pp. 21-34, 2026, DOI:10.32604/cju.2025.068908 - 28 February 2026

    Abstract Prostate-specific membrane antigen (PSMA) is a surface membrane antigen that is highly overexpressed in prostate cancer, with heterogenous expression throughout the natural history of the disease. This has generated significant interest as a potential biomarker for use in early diagnosis and treatment of prostate cancer. We reviewed the literature surrounding PSMA and its current clinical applications in diagnosing and managing early prostate cancer that is confined to the prostate and local lymph nodes. A search on PubMed, Medline, and Web of Science was performed using the following keywords: “PSMA”, “Prostate Specific Membrane Antigen”, “Prostate cancer”,… More >

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