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  • Open Access


    Update on Fe-dependent oxidative metabolism in vivo: An integrative view

    Natacha E PILONI, Elizabeth ROBELLO, Julián G BONETTO, Susana PUNTARULO*

    BIOCELL, Vol.40, No.1, pp. 39-42, 2016, DOI:10.32604/biocell.2016.40.039

    Abstract Fe is essential for human life because it constitutes the required cofactor for proteins of diverse biological functions. However, the development of oxidative stress by exposure to excessive Fe, share signaling pathways with other treatments including activation of redox-sensitive factors. This study was focused on the comparison on the effects of Fe in the brain and other organs in vivo. The oxidative effects triggered by Fe overload strongly depend not only on the administration protocol, but also on the Fe-compound used, and the studied organ. In both the liver and the brain, Fe content drastically increased after Fe-dextran administration. However,… More >

  • Open Access


    MicroRNA expression profile and lipid metabolism characteristics in liver of rat undergoing high-fat diet

    Wen JING1,§, Chuanfen LI2,3,§, Yingli LU4, Lianshi FENG4

    BIOCELL, Vol.43, No.3, pp. 129-138, 2019, DOI:10.32604/biocell.2019.06087

    Abstract This study aimed to investigate the microRNA expression profile and the characteristics of lipid metabolism in the livers of rats undergoing a high-fat diet. Fifty male Sprague-Dawley (SD) rats were divided into a standard chow group (C group, N = 10) and a high-fat diet group (H group, N = 40). After 12 weeks, the rat body weight, body length, fat mass, and serum lipid concentration were measured. The expression profile of microRNAs and the gene and protein expression levels involved in lipid metabolism in rat liver were detected. Body fat and serum lipid concentrations were all significantly higher in… More >

  • Open Access


    A Theoretical Model for Simulating Effect of Parathyroid Hormone on Bone Metabolism at Cellular Level

    Yanan Wang, Qing-Hua Qin, Shankar Kalyanasundaram

    Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 101-112, 2009, DOI:10.3970/mcb.2009.006.101

    Abstract A mathematical model is developed for simulating anabolic behaviour of bone affected by Parathyroid Hormone (PTH) in this paper. The model incorporates a new understanding on the interaction of PTH and other factors with the RANK-RANKL-OPG pathway into bone remodelling, which is able to simulate anabolic actions of bone induced by PTH at cellular level. The RANK-RANKL-OPG pathway together with the dual action of TGF-$\beta$, which represent the core of coupling behaviour between osteoblasts and osteoclasts which are two cell types specialising in the maintenance of bone integrity, are widely considered essential for the regulation of bone remodelling at cellular… More >

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