Open Access
ARTICLE
Nitric oxide metabolism in heart mitochondria
Tamara ZAOBORNYJ, Darío E. IGLESIAS, Silvina S. BOMBICINO, Alberto BOVERIS, Laura B. VALDEZ*
* Address correspondence to: Laura B. Valdez, lbvaldez@ffyb.uba.ar
BIOCELL 2016, 40(1), 55-58. https://doi.org/10.32604/biocell.2016.40.055
Abstract
Normal cardiac function is accomplished through a continuous energy supply provided by
mitochondria. Heart mitochondria are the major source of reactive oxygen and nitrogen species: superoxide
anion (O
2-) and nitric oxide (NO). NO production by mitochondrial NOS (mtNOS) is modified by metabolic
state and shows an exponential dependence on Δψ. The interaction between mtNOS and complexes I and IV
might be a mechanism involved in the regulation of mitochondrial NO production. NO exerts a high affinity,
reversible and physiological inhibition of cytochrome c oxidase activity. A second effect of NO on the respiratory
chain is accomplished through its interaction with ubiquinol-cytochrome c oxidoreductase. The ability of
mtNOS to regulate mitochondrial O
2 uptake and O
2- and H
2O
2 productions through the interaction of NO with
the respiratory chain is named mtNOS functional activity. Together, heart mtNOS allows NO to optimize the
balance between cardiac energy production and utilization, and to regulate the steady-state concentrations of
other oxygen and nitrogen species.
Keywords
Cite This Article
ZAOBORNYJ, T., IGLESIAS, D. E., BOMBICINO, S. S., BOVERIS, A., VALDEZ, L. B. (2016). Nitric oxide metabolism in heart mitochondria.
BIOCELL, 40(1), 55–58. https://doi.org/10.32604/biocell.2016.40.055