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  • Open Access


    Microstructures and Nanomechanical Properties of Additively Manufactured Metallic Stents

    Enzoh Langi1, Liguo Zhao2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.010163

    Abstract Additive manufacturing emerges as an innovative technology to fabricate medical stents used to treat blocked arteries. However, there is a lack of study of underlying microstructure and mechanical properties of additively manufactured stent. In this work, additively manufactured 316L stainless steel stent was investigated, with electrochemical polishing being used to improve the surface finish. Microstructural characterisation was carried out using optical microscopy, scanning electron microscopy, and electron backscatter diffraction. The hardness and elastic modulus were measured using Berkovich nanoindentation, with an emphasis on the effect of grain orientation. In addition, spherical nanoindentation was used to obtain indentation stress-strain curves based… More >

  • Open Access


    Early-Age Properties Development of Recycled Glass Powder Blended Cement Paste: Strengths, Shrinkage, Nanoscale Characteristics, and Environmental Analysis

    Zhihai He1,2, Menglu Shen1, Jinyan Shi3,*, Jingyu Chang1, Víctor Revilla-Cuesta4, Osman Gencel5

    Journal of Renewable Materials, Vol.11, No.4, pp. 1835-1852, 2023, DOI:10.32604/jrm.2023.024887

    Abstract Recycling solid waste in cement-based materials cannot only ease its load on the natural environment but also reduce the carbon emissions of building materials. This study aims to investigate the effect of recycled glass powder (RGP) on the early-age mechanical properties and autogenous shrinkage of cement pastes, where cement is replaced by 10%, 20% and 30% of RGP. In addition, the microstructure and nano-mechanical properties of cement paste with different RGP content and water to binder (W/B) ratio were also evaluated using SEM, MIP and nanoindentation techniques. The results indicate that the early-age autogenous shrinkage decreases with the increase of… More > Graphic Abstract

    Early-Age Properties Development of Recycled Glass Powder Blended Cement Paste: Strengths, Shrinkage, Nanoscale Characteristics, and Environmental Analysis

  • Open Access


    Microenvironment and cell mechanics


    BIOCELL, Vol.46, No.7, pp. 1629-1632, 2022, DOI:10.32604/biocell.2022.018364

    Abstract Microenvironment contains biophysical and biochemical elements to maintain survival, growth, proliferation, and differentiation of cells. Any change can lead to cell response to the mechanical forces, which can be described by elasticity. It is an indicator of a cell’s state since it plays an important role in many cellular processes. In many cases, cell elasticity is measured by using discontinuous manner, which may not allow elucidating real-time activity of individual live cells in physiological condition or cell response against microenvironmental changes. I argue that measuring cell elasticity using continuously repetitive nanoindentation technique is important that should be considered. As an… More >

  • Open Access


    Crystalline Plasticity on Copper (001), (110), and (111) Surfaces during Nanoindentation

    Haiyi Liang1, C.H. Woo1,2, Hanchen Huang3, A.H.W. Ngan4, T.X. Yu5

    CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.1, pp. 105-114, 2004, DOI:10.3970/cmes.2004.006.105

    Abstract Molecular dynamics (MD) simulations are performed to study crystalline plasticity during nano-indentation by comparing the elastic-plastic response of three copper substrates with surfaces (001), (110), and (111) crystallographic planes. The effects of elastic anisotropy and crystallographic symmetry on the reduced modulus, dislocation nucleation, and subsequent microstructure evolution, are investigated. The reduced modulus of (111) surface is found to be the largest, while that of (001) surface is the smallest. Elastic stress distribution calculated from finite element method (FEM) is qualitatively consistent with the MD simulation results. Significant differences exist in the deformation behavior in the three different crystallographic orientations. The… More >

  • Open Access


    Derivation of the Stress-Strain Behavior of the constituents of Bio-Inspired Layered TiO2/PE-Nanocomposites by Inverse Modeling Based on FE-Simulations of Nanoindentation Test

    G. Lasko, I. Schäfer, Z. Burghard, J. Bill, S. Schmauder, U. Weber, D. Galler

    Molecular & Cellular Biomechanics, Vol.10, No.1, pp. 27-42, 2013, DOI:10.3970/mcb.2013.010.027

    Abstract Owing to the apparent simple morphology and peculiar properties, nacre, an iridescent layer, coating of the inner part of mollusk shells, has attracted considerable attention of biologists, material scientists and engineers. The basic structural motif in nacre is the assembly of oriented plate-like aragonite crystals with a ’brick’ (CaCO3 crystals) and ’mortar’ (macromolecular components like proteins) organization. Many scientific researchers recognize that such structures are associated with the excellent mechanical properties of nacre and biomimetic strategies have been proposed to produce new layered nanocomposites. During the past years, increasing efforts have been devoted towards exploiting nacre’s structural design principle in… More >

  • Open Access


    Intracellular Calcium Waves in Bone Cell Networks under Single Cell Nanoindentation

    X. Edward Guo∗,†,‡, Erica Takai∗,‡, Xingyu Jiang§, Qiaobing Xu§, George M. Whitesides§, James T. Yardley, Clark T. Hung*, Eugene M. Chow||, Thomas Hantschel∗∗, Kevin D. Costa

    Molecular & Cellular Biomechanics, Vol.3, No.3, pp. 95-108, 2006, DOI:10.3970/mcb.2006.003.095

    Abstract In this study, bone cells were successfully cultured into a micropatterned network with dimensions close to that of in vivo osteocyte networks using microcontact printing and self-assembled monolyers (SAMs). The optimal geometric parameters for the formation of these networks were determined in terms of circle diameters and line widths. Bone cells patterned in these networks were also able to form gap junctions with each other, shown by immunofluorescent staining for the gap junction protein connexin 43, as well as the transfer of gap-junction permeable calcein-AM dye. We have demonstrated for the first time, that the intracellular calcium response of a… More >

  • Open Access


    Effective Interfacial Thickness in Dissimilar Materials through Nanoindentation

    S. S. Pulla1, Y. C. Lu2

    CMC-Computers, Materials & Continua, Vol.29, No.3, pp. 263-278, 2012, DOI:10.3970/cmc.2012.029.263

    Abstract The nanoindentation technique is used to quantify the interfaces between dissimilar materials. The interfaces can be generally referred as to the transition regions in polymers due to environmental aging, or the regions between fibers and polymer matrix in composites, or other similar situations. It is proposed to use a nanoindenter equipped with small spherical tip to cross-indent the interfaces of dissimilar materials. The nanoindentation tests were carried out through 3-dimensional finite element simulations with varying properties of the two dissimilar materials, including various combinations of modulus (E1/E2), yield strength (σy1y2), hardening index (n1/n2), and the interface sizes (R/T). The mechanical… More >

  • Open Access


    AFM and Nanoindentation Studies of Bone Nodules on Chitosan-Polygalacturonic Acid-Hydroxyapatite Nanocomposites

    R. Khanna1,2, D. R. Katti1, K. S. Katti1

    CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 530-556, 2012, DOI:10.3970/cmes.2012.087.530

    Abstract Here we report a new in situ nanoindentation technique developed to evaluate the composite mechanical behavior of cell-biomaterial construct under physiological conditions over the time scale of bone nodule generation. Using this technique, mechanical behavior of osteoblast cell-substrate interfaces on tissue engineered materials (chitosan-polygalacturonic acid-nanohydroxyapatite (CPH) films) is investigated. Mechanical behavior of cells in the elastic regime over the time scale of cell adhesion (1 day), proliferation (4 days), development (8 days) and maturation (22 days) of bone nodules is evaluated. Our results indicate that the elastic properties of flat cells are higher (indicating stiffer response, after 4 days, as… More >

  • Open Access


    Modelling of the Frequency Response to Dynamic Nanoindentation of Soft Hydrated Anisotropic Materials: Application to Articular Cartilage

    Taffetani M.1, Bertarelli E.1,2, Gottardi R.3,4, Raiteri R.5, Vena P.1,2

    CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.5, pp. 433-460, 2012, DOI:10.3970/cmes.2012.087.433

    Abstract Dynamic nanoindentation is a novel nanomechanical testing that is being increasingly used to characterize the frequency response of viscoelastic materials and of soft hydrated biological tissues at the micrometric and nanometric length scales. This technique is able to provide more information than those obtained by simple indentation; however, its interpretation is still an open issue for complex materials such as the case of anisotropic biological tissues that generally have a high water content. This work presents a numerical model to characterize the frequency response of poro-elastic tissues subjected to harmonic indentation loading with particular regard to the effect of geometrical… More >

  • Open Access


    Multiscale Simulation of Nanoindentation Using the Generalized Interpolation Material Point (GIMP) Method, Dislocation Dynamics (DD) and Molecular Dynamics (MD)

    Jin Ma, Yang Liu, Hongbing Lu, Ranga Komanduri1

    CMES-Computer Modeling in Engineering & Sciences, Vol.16, No.1, pp. 41-56, 2006, DOI:10.3970/cmes.2006.016.041

    Abstract A multiscale simulation technique coupling three scales, namely, the molecular dynamics (MD) at the atomistic scale, the discrete dislocations at the meso scale and the generalized interpolation material point (GIMP) method at the continuum scale is presented. Discrete dislocations are first coupled with GIMP using the principle of superposition (van der Giessen and Needleman (1995)). A detection band seeded in the MD region is used to pass the dislocations to and from the MD simulations (Shilkrot, Miller and Curtin (2004)). A common domain decomposition scheme for each of the three scales was implemented for parallel processing. Simulations of indentation were… More >

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